Study relationship between multiple sclerosis and migraine

Background: Each person experiences headaches in his/her life. Some studies have shown a significant relationship between Migraine and MS. In these patients there can be a variety of clinical symptoms such as muscle weakness, sensory loss, ataxia, optic neuritis. Optic neuritis in MS is a relatively common symptom that can cause blurred vision, headaches (especially frontal ones) and painful eye movements. Headache is a clinical symptom that makes people visit neurologists. There are several diagnoses for headaches including migraine. In this study, we evaluated the possibility of a significant relationship between migraine and MS.Methods: In this case-control study, 134 MS patients and 134 sex and age matched controls were selected randomly from all patients referred to hospital. Their information about MS and migraine was collected and analyzed by SPSS v.21.Results: The Mean age of cases in this study was 41.5±9.4 years. The gender of 73.13% of patients was female. In MS patients with chronic headaches, 36 people (42.9%) and in Controls 22 people (38.6%) had migraine. In this study it was found that people with MS, experience more migraine attacks compared to the controls (OR=3 and P=0.05). Further investigation showed that, unlike aura type, migraine without aura had a significant relation with the MS (OR=1.94 and P=0.04). Also, it seems that the number of migraine attacks in patients with MS is significantly more than the controls.Conclusions: Finally it seems that there is a positive association between MS and migraine. The relationship between migraine without aura and MS is obvious, but the relation between aura type and MS is not clear, yet

Albumin impact on clinical practice and complications of ischemic stroke in patients with stroke

Background: Cerebrovascular disease is the third common leading cause of death after cancer and heart disease in the United States. Also cerebrovascular disease is the most common neurological disease which can lead to complications or mortality. The incidence of ischemic stroke increases with age, and almost two thirds of cases occur in people over 65 years. Albumin as a blood thinner to reduce blood viscosity and sufficient vasodilation in response to low oxygen increases blood flow in ischemic and normal brain. The aim of this study was to investigate the Albumin impact on clinical practice and complications of ischemic stroke in patients with stroke.Methods: This is a randomized clinical study that has been done on 100 patients with ischemic stroke included 54 male and 46 female referred to Alavi hospital in Ardabil. Patients with inclusion criteria randomly divided in two similar sample size groups. For case group we prescribed albumin 20% and for control group normal-saline. NIHSS questionnaire completed for each patient based on their interview and medical documents in hospital according the specialist doctor idea. Collected data analysed by statistical methods in SPSS.19.Results: From all patients, 41% have HTN, 30% Diabetes, 32% ischemic stroke type cortical in branch MCA and 14% in brain stem. The highest risk factor for stroke was in people with high blood pressure. The mean of NIHSS in the end of third month after intervention in the patients with cortical ischemia in albumin group with 24.8±5.1 was lower than placebo group with 31.3±3 and this difference was statistically significant (p = 0.012).Conclusions: Results showed that in cortical ischemic stroke there was a significant relationship between receiving albumin and decreasing NISHH score. But there was no significant relationship between receiving albumin and decreasing NISHH score in Lacunar and brain stem stroke

Prevalence of migraine and tension headaches and related factors, 2014

Background: Migraine and tension type headache (TTH) due to their effect on life and reducing efficacy are two major problems in human life. This study aimed to investigate the prevalence of migraine and tension headaches and factors affecting their occurrence in Ardabil, Iran.Methods: In this cross sectional descriptive study, 900 cases were selected randomly from referral outpatients to neurology clinic of Ardabil, Iran during 2014. Diagnosis of headache type was confirmed by a neurologist and required information was obtained by general and neurological examinations of patients and recorded in a checklist and then analyzed by statistical methods in SPSS.19.Results: Of all referral cases, 767 (85.2%) have headache which from them 27.9% have migraine and 48.2% have TTH. Among migraine patients, 15.4% was male and 84.6% was female, and among TH patients 38.1% were male and 61.9% were female. Most location of headache in migraine and TH patients was frontal and temporal with 37.8% and 28.9%, respectively. Frequency of headache attacks in migraine patients was often weekly or monthly (74.3%) and in TH patients was often daily or weekly (85.7%). The prevalence of headache history among migraine patients was significantly more than TH patients (43.5% versus 34.1%).Conclusions: Results showed that the prevalence of migraine and TH was high in our society and most of headache attacks were weekly or daily. Because of headache causes to private and social dysfunctions, doing studies to determine risk factors in incidence of migraine and tension headaches for early detection of them is essential

Relation between transcranial doppler findings, neuroimaging and functional state in the first days of acute cerebrovascular accidents- hemorrhagic and ischemic in patients admitted to the Ardabil city hospital during 2015-2016

Background: Cerebrovascular accident (CVA) is the third leading cause of death in the United States. Considering the diagnostic and clinical value of sonography of extra cranial vessels of the brain, identifying findings obtained from patients suspected of having CVA and Transient Ischemic Attack (TIA) and their prevalence is of great importance. The aim of this study was to investigate the relation between TCD finding, neuroimaging and functional state of ischemic and hemorrhagic CVA patients.Methods: This was a cross-sectional study that has been done on 100 stroke patients admitted to Ardabil city hospital from March 2015 to March 2016. Patients underwent to CT-scan, doppler sonography, and TCD. The obtained data were analyzed by statistical methods in SPSS version 21.Results: The mean age of the patients was 66.3±11 years and 53% were women. High blood pressure, history of heart disease, smoking, and diabetes were the major risk factors in the present study. Fifty eight percent of the patients had moderate to severe disability in their functional status. Atheroma plaques, intima-media thickening, and the change of speed in the external carotid artery were most frequent in doppler sonography investigations. There was no significant correlation between the obtained results from TCD and the functional status of the patients.Conclusions: Considering the non-significant correlation between TCD results and the functional state of the patients in this study, for exactly study of this topic, study the TCD of patients on several different days and after starting treatment is essential

Quality of life among Ardabil patients with beta-thalassemia major

Background: Thalassemia as the most common genetic disorder worldwide is regarded as a serious problem in public health issues in the Mediterranean region. Patients with beta-thalassemia major experience physical, psychological and social problems that lead to decreased quality of life. The aim of this study was to assess health-related quality of life and its determinants among patients with major beta-thalassemia.Methods: This was a population-based cross-sectional survey of quality of life. Population with thalassemia major (aged ≥ 2 years) of both genders who had records in Thalassemia Clinic of Bu-Ali Hospital, and those who regularly refer for blood transfusion or follow-up visits. Data were collected from December 2013 to May 2014.The self-administered short form-36 (SF-36) questionnaire was used to measure quality of life in patients with thalassemia. Data were analysed using descriptive statistical tests (mean, SD, and frequency), and inferential statistical test (t-test) in SPSS.17 software.Results: Our samples were 20 men and 23 women. The median age was 20 years (2-42). After reviewing the patients' quality of life, it was observed that the mean score for physical function was 79.8, role limitations due to physical reasons 78.8, bodily pain 74.4, general health 59.1, fatigue or vitality 63.3, social function 70.21, role limitations due to psychological reasons (emotional) 77.3 and mental health 65.4. On two scales, role physical (P = 0.33) and role emotional (P = 0.13), the men showed significantly lower scores than the women.Conclusions: After reviewing the patients' quality of life, the highest quality in physical function and lowest quality in general health of patients were observed. In the quality of care data all scales were in very good level except general health.

Study relationship between multiple sclerosis and migraine

Background: Each person experiences headaches in his/her life. Some studies have shown a significant relationship between Migraine and MS. In these patients there can be a variety of clinical symptoms such as muscle weakness, sensory loss, ataxia, optic neuritis. Optic neuritis in MS is a relatively common symptom that can cause blurred vision, headaches (especially frontal ones) and painful eye movements. Headache is a clinical symptom that makes people visit neurologists. There are several diagnoses for headaches including migraine. In this study, we evaluated the possibility of a significant relationship between migraine and MS.Methods: In this case-control study, 134 MS patients and 134 sex and age matched controls were selected randomly from all patients referred to hospital. Their information about MS and migraine was collected and analyzed by SPSS v.21.Results: The Mean age of cases in this study was 41.5±9.4 years. The gender of 73.13% of patients was female. In MS patients with chronic headaches, 36 people (42.9%) and in Controls 22 people (38.6%) had migraine. In this study it was found that people with MS, experience more migraine attacks compared to the controls (OR=3 and P=0.05). Further investigation showed that, unlike aura type, migraine without aura had a significant relation with the MS (OR=1.94 and P=0.04). Also, it seems that the number of migraine attacks in patients with MS is significantly more than the controls.Conclusions: Finally it seems that there is a positive association between MS and migraine. The relationship between migraine without aura and MS is obvious, but the relation between aura type and MS is not clear, yet

Comparative study of the diagnostic value of EMG-NCV and MRI in patients with radicular pain in the neck and back

Introduction: Spinal radiculopathy is the most common cause of back pain and pain of upper or lower limb. Radiography (MRI or X-ray) and electrodiagnostic measures, including EMG-NCV, can be employed for diagnosis of radiculopathy. Each of the mentioned diagnostic methods has its own limitations. Thus, a comparative study between these methods is essential for accurate diagnosis of patients with clinical symptoms of radiculopathy. Methods: In this cross-sectional study, 96 patients with radicular back pain who had visited neurology clinic in Ardabil Hospital were enrolled. All the patients had MRI, EMG, and NCV results in their files so the present study did not impose any excessive costs on the patients. MRI was used as the diagnostic gold standard and other tests were compared with it. The sensitivity, specificity, positive predictive value, and negative predictive value were estimated for each test. Findings: The results of this study indicated a relatively high diagnostic value of lumbar radiculopathy for EMG test and it had a relatively high compatibility with the results of MRI test. Unlike EMG, NCV test did not show any significant agreement with MRI results. Also it was recommended that EMG for back be done with high obsession when necessary. Conclusions: Doing EMG test in patients with radicular pain can be a helpful diagnostic test for spinal radiculopathies and NCV test is not worth doing for diagnosis of radiculopathy of the spine. [Arch Clin Exp Surg 2018; 7(1.000): 19-23

Somatoform dissociation, fatigue severity and pain behavior compared in patients with migraine headache and in healthy individuals

The prevalence of migraine in the world is about 15 and 7% among women and men, respectively. The purpose of this study was comparison of somatoform dissociation, fatigue severity and pain behavior in patients with migraine headache and its relationship with coping strategies. This descriptive analytical study has been done on 120 patients with migraine headache and 120 healthy subjects were selected randomly. Data collected by somatoform dissociation questionnaire (SDQ-20), fatigue severity scale, pain behavior scale and coping strategies scale. For data analysis we used SPSS.19. The means of the somatoform dissociation, pain behavior scale, help searching subscale and pain compliant in migraine and healthy subjects were statistically significant. There was not significant difference in avoidance subscales between the two groups. Comparison of fatigue severity in patients with migraine and control group was meaningful. There was significant positive correlation between all four scales and coping strategies. It seems that these symptoms can play an important role in this disease; thus, their careful evaluation in the treatment of migraine headache is essential

Comparing the Frequency of Helicobacter pylori Infection in Patients with and without Epilepsy in the Northwest of Iran (2019)

Background and Objective: Helicobacter pylori infection is a chronic bacterial infection in humans, and its link to epilepsy has been reported in some studies. This study was conducted to compare the frequency of Helicobacter pylori infection in patients with and without epilepsy. Methods: This case-control study was conducted on 234 patients with focal and generalized epilepsy (the case group consisted of 88 males and 146 females) referring to Alavi Hospital in Ardabil, Iran and 234 individuals without epilepsy (the control group consisted of 88 males and 146 females) during 2019. Stool samples were taken from the subjects to assess the Helicobacter pylori stool antigen. Demographic information, including age, gender, place of residence, a history of alcohol, cigarette, hookah, and opium use, and the test result of the Helicobacter pylori stool antigen, were collected in a checklist. Results: The frequency of Helicobacter pylori infection was determined to be 67.2% in the case group and 71.1% in the control group, and no statistically significant difference was found between the case and control groups. Cigarette and opium use had statistically significant relationships with epilepsy (P<0.05). Moreover, opium users had a 6.92 times higher odds rate (OR) of contracting Helicobacter pylori infection than other individuals (CI 95%=1.05-45, OR=6.92, P<0.04). Conclusion: No difference was observed in Helicobacter pylori infection between individuals with and without epilepsy