Selected hematology at time of admission by age group in influenza A H1N1pdm confirmed fatalities (excluding patients with influenza A H1N1pdm nosocomial infections unless otherwise reported), Argentina, June 15–July 31, 2009.

**<p>Lymphopenia was defined as <3000 cells/ml for patients under 5 years old, <2000 cells/ml for patients 5-12 years old and <1,500 cells/ml for patients over 12 years old.</p>††<p>Anemia was defined as less than 11 g/dl of hemoglobin (Hb) for patients less than 5 years old and for pregnant women (>15 years old), less than 11.5 g/dl Hb for patients 5–12 years old, less than 12 g/dl Hb for patients 12–15 years old and for non-pregnant women (>15 years old), and less than 13 g/dl Hb for men 15 years and older.</p>§§<p>“Acidosis or hypoxemia” is defined as pH under 7.36 or oxygen saturation less than 96%.</p

Selected X-ray patterns at time of admission by age group in influenza A H1N1pdm confirmed fatalities (excluding patients with influenza A H1N1pdm nosocomial infections unless otherwise reported), Argentina, June 15^th–July 31^st, 2009.

¶¶<p>COPD, Asthma, atelectasis, tuberculosis, respiratory failure.</p>***<p>Fever syndrome, septic shock, leukemia, gastrointestinal problems, pregnancy, HIV/AIDS.</p

Mean number of days from date of onset to date of first doctor visit (A), hospitalization (B), and antiviral treatment (C); Mean number of days from first doctor visit (D) and hospitalization (E) to antiviral treatment among influenza A H1N1pdm fatalities by epidemiological week of onset.

<p>Mean number of days from date of onset to date of first doctor visit (A), hospitalization (B), and antiviral treatment (C); Mean number of days from first doctor visit (D) and hospitalization (E) to antiviral treatment among influenza A H1N1pdm fatalities by epidemiological week of onset.</p

Description of pregnant, postpartum and fertile age women among influenza A H1N1pdm confirmed deceased patients, Argentina, June 15^th–July 31^st, 2009.

<p><b>n/a</b> not applicable.</p

Pandemic H1N1 (influenza A H1N1pdm) confirmed hospitalizations and deaths by week of symptom onset and case fatality proportion among hospitalized cases, Argentina, May 3^rd 2009–August 29^th 2009.

<p>Pandemic H1N1 (influenza A H1N1pdm) confirmed hospitalizations and deaths by week of symptom onset and case fatality proportion among hospitalized cases, Argentina, May 3^rd 2009–August 29^th 2009.</p

Treatment and Clinical course of 332 influenza A H1N1pdm-confirmed fatalities, June 15^th–July 31^st, 2009.

**<p>eleven case-patients were ventilated outside of the ICU because of space-limitations.</p>***<p>excluding influenza A H1N1pdm nosocomial infections.</p

Comorbidities^* and underlying conditions among influenza A H1N1pdm confirmed fatalities by age groups, Argentina, June 15^th–July 31^st, 2009.

*<p>Comorbidities as defined by the Advisory Committee on Immunization Practices ¹⁰.</p>†<p>Including asthma.</p>§<p>Excluding hypertension.</p>¶<p>Including diabetes.</p>#<p>Persons who have immunosuppression (including immunosuppression caused by medications or by human immunodeficiency virus, HIV).</p>**<p>Persons who have any condition (e.g., cognitive dysfunction, spinal cord injuries, seizure disorders, or other neuromuscular disorders) that can compromise respiratory function or the handling of respiratory secretions or that can increase the risk for aspiration.</p>††<p>Including cerebrovascular disease, cerebral palsy, epilepsy, down syndrome, neurochronic disease.</p>§§<p>Does not include former and passive smokers.</p>¶¶<p>Women only.</p><p><b>n/a</b> not applicable.</p

Selected symptoms and physical signs at time of admission by age group in influenza A H1N1pdm confirmed fatalities (excluding patients with influenza A H1N1pdm nosocomial infections unless otherwise reported), Argentina, June 15^th–July 31^st, 2009.

*<p>Unless otherwise stated.</p>†<p>Median (IQR).</p>#<p>Elevated respiration rate was defined as more than 40 breaths per minute for patients less than 5 years old and 25 breaths per minute for patients 5+ years old.</p>§<p>Elevated resting heart rate was defined as more than 120 beats per minute for patients less than 5 years old and 100 beats per minute for patients 5+ years old.</p>¶<p>Low systolic tension was defined as <90 mmHg.</p

Mortality, Severe Acute Respiratory Infection, and Influenza-Like Illness Associated with Influenza A(H1N1)pdm09 in Argentina, 2009

<div><h3>Introduction</h3><p>While there is much information about the burden of influenza A(H1N1)pdm09 in North America, little data exist on its burden in South America.</p> <h3>Methods</h3><p>During April to December 2009, we actively searched for persons with severe acute respiratory infection and influenza-like illness (ILI) in three sentinel cities. A proportion of case-patients provided swabs for influenza testing. We estimated the number of case-patients that would have tested positive for influenza by multiplying the number of untested case-patients by the proportion who tested positive. We estimated rates by dividing the estimated number of case-patients by the census population after adjusting for the proportion of case-patients with missing illness onset information and ILI case-patients who visited physicians multiple times for one illness event.</p> <h3>Results</h3><p>We estimated that the influenza A(H1N1)pdm09 mortality rate per 100,000 person-years (py) ranged from 1.5 among persons aged 5–44 years to 5.6 among persons aged ≥65 years. A(H1N1)pdm09 hospitalization rates per 100,000 py ranged between 26.9 among children aged <5 years to 41.8 among persons aged ≥65 years. Influenza A(H1N1)pdm09 ILI rates per 100 py ranged between 1.6 among children aged <5 to 17.1 among persons aged 45–64 years. While 9 (53%) of 17 influenza A(H1N1)pdm09 decedents with available data had obesity and 7 (17%) of 40 had diabetes, less than 4% of surviving influenza A(H1N1)pdm09 case-patients had these pre-existing conditions (p≤0.001).</p> <h3>Conclusion</h3><p>Influenza A(H1N1)pdm09 caused a similar burden of disease in Argentina as in other countries. Such disease burden suggests the potential value of timely influenza vaccinations.</p> </div

Description of case-patients with available risk factor data identified during active case-finding in 2009 and during three consecutive health utilization surveys in 2010, three cities in Argentina.

<p>2009 H1N1 denotes influenza A (H1N1)pdm09, SARI denotes severe acute respiratory illness, and ILI denotes influenza-like illness.</p>a<p>among cases with available age, pregnancy, obesity, chronic obstructive pulmonary disease, or asthma status data.</p>b<p>The age of case-patients is significantly associated with decedent, SARI, or ILI case-status in linear regression (p≤0.001).</p>c<p>The sex of case-patients is significantly associated with decedent, SARI, or ILI case-status in Fisher Exact testing (p = 0.01).</p>d<p>The characteristic is significantly associated with decedent, SARI, or ILI case-status in Fisher Exact testing (p<0.001).</p