Rapidly progressive HCV cirrhosis in a hypogammaglobulinemic patient

Contrary to the widely known view of the insidious, slowly progresive pattern of hepatitis C, a rapidly progressive cirrhotic form can devolop in immunodeficient conditions. Hepatitis C leads to cirrhosis in immunocompetent hosts after 20 years of infection however in hypogammaglobulinemic patients disease progresses faster, leading to cirrhosis and death within 10 years of diagnosis and frequently earlier. Here we present a 57-year-old woman with common variable immunodeficiency infected with hepatitis C after antral and duodenal resection and gastrojejenostomy operation in another hospital for lymphoma mimicking duodenal nodular hyperplasia which then rapidly progressed to decompansated cirrhosis in less than two years

Massive Ascites as the Initial Manifestation of Mantle Cell Lymphoma: A Challenge for the Gastroenterologist

Involvement of the serosa may be the presenting feature in a wide and complex variety of lymphoproliferative diseases, with differing clinical outcomes covering a spectrum of benign and malignant conditions. Effusions involving peritoneal and pericardial cavities are uncommon during the course of hematological malignancies. Obstructive and/or infiltrative tumor mass or vascular leakage due to stimulation by vascular endothelial growth factor contribute to the pathogenesis. In addition to clinical findings, cytomorphology and flow cytometric immunophenotyping of the serosal fluid yield valuable information in the differential diagnosis of lymphocytic infiltrates. Herein, we describe the case of primary mantle cell lymphoma in a 75-year-old man presenting with abdominal fullness and weight loss, suggesting a gastrointestinal pathology

Acute severe hepatitis and hemophagocytosis in adult onset Still’s disease

We report a 44-year-old male Turkish patient with adult onset Still's disease (AOSD) complicated by acute severe hepatitis and hemophagocytosis. Initial investigations for fever and rapidly progressive elevation of liver function tests were not diagnostic. Routine evaluations of liver and bone marrow biopsies missed the fundamental pathology. Extremely elevated ferritin levels led to a more detailed search, and immunohistochemical staining with CD68 for macrophages revealed extensive hemophagocytosis in both the first and second bone marrow biopsies, as well as in the liver biopsy. Treatment with steroid and cyclosporine A induced complete remission

Hematological aftermath of the radiation accident in Istanbul.

Purpose: The effects of radiation exposure are long-lasting. Long-term monitoring is imperative to diagnose late effects and improve our far-sightedness about possible events in the future. A radiation accident occurred in Istanbul in 1998 that resulted in mild to moderate acute radiation syndrome (ARS). In this study we aimed to investigate the changes in hematological parameters at the long-term follow-up of ARS patients

TRANSFUSION RELATED ACUTE LUNG INJURY

Transfusion related acute lung injury is one of the most important causes of morbidity and mortality associated with transfusions. It is characterized with non cardiac pulmonary edema. The exact mechanism is not known because there are limited cases and studies in this subject. It can be seen after any type of blood and blood product transfusions. Herein, we present a case that developed thrombocytopenia, platelet transfusion resistance, acute renal failure and transfusion related acute lung injury after administration of chemotherapy for refractory anemia with excess blasts