Reinvestigation of the Reaction of Phenacy lMalononitrile with Hydrazines under Solvent Conditions

Phenacylmalononitrile 3 reacts with hydrazine hydrate in refluxing dioxan to afford the iminopyridazine derivative 6 and the pyrazolo[3,4-c]pyridazine derivative 7.Compound 3 reacts also with phenylhydrazine in refluxing ethanol to afford the iminopyridazine derivative 11 along with the phenylhydrazone derivative 12. Compound 12 could be cyclized into the pyrazolo[3,4-c]pyridazine derivative 13 upon reflux with sodium ethoxide

Synthesis and Molluscicidal Activity of Some Newly Substituted Chromene and Pyrano[2,3-c]pyrazole Derivatives

The arylidene derivatives 3a-f react with 1,3-cyclohexanedioneand dimedone 4a,b to afford the 4-(2- or 3-pyridyl) or 4-pipronyl-chromene derivatives 6a-l. The arylidene derivatives 3a-c react with the pyrazolone derivatives 7a,b to afford the pyrano[2,3-c]pyrazole derivatives 9af.The molluscicidal activity of the synthesized compounds towards Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni, was investigated and most of them showed weak to moderate activity.

Heterocyclic synthesis with ω-bromoacetophenone: Synthesis of some new pyrazole, pyridazine and furan derivatives

p-Bromophenacylnitrile derivatives 3a,b react with hydrazinederivatives under different conditions to afford the diaminopyrazoles 4a,b, the pyridazine-6-imines 5a,b,and 5-aminopyrazoles 11a,b. Refluxing of 5a in ethanol/hydrochloric acid mixture furnished its transformation into the pyridazine-6-one 6 while 5b under the same reaction conditions, underwent ring contraction expelling phenyl hydrazine to afford the furan derivative 7.Compound 7 could also be obtained from 3a upon refluxin ethanol catalyzed by triethylamine. Ethyl  phenacylcyanoacetate 3b reacts with hydrazine hydrate and phenylhydrazine to afford the 4-phenacylpyrazole derivatives11a,b respectively. Compound 3b afforded a mixture ofthe two furan derivatives 12 and 13 upon reflux in ethanolcatalyzed by triethylamine. Compound 3b also undergoesthe coupling reaction with the aromatic diazoniumsalts 14a-d to afford the pyrazole derivatives 16a-d presumablyvia the hydrazo derivatives 15a-d respectively

Production of clean gasoline from the condensate

The locally available Algerian bentonite is explored to prepare catalysts for the isomerization of the light fractions of Algerian condensate to produce high quality gasoline of high octane number. Satisfying results are obtained which render these catalysts applicable for a large scale production

Design, synthesis and anticancer evaluation of novel pyrazole, pyrazolo[3,4-d]pyrimidine and their glycoside derivatives

The chalcone derivatives 3a,b were cyclized upon reaction with thiourea to give the pyrazolo[3,4-d]pyrimidine derivatives 5a,b. Condensation of 5a,b and their hydrazide derivatives 8a,b with cyclic and acyclic glucose gave the condensed S- andN-glycosides 7a,b and 9a,b, respectively. Reaction of 3b with ethyl cyanoacetate followed by reaction with cyclic glucose afforded a mixture of the O- and/or N-glycoside isomers 12 and 13, respectively. The pyrazolo[3,4-c]pyrazole derivative 14 was also obtained from the reaction of 3b with hydrazine hydrate. A number of the synthesized compounds were screened for their antitumor activity against three different tumor cell lines HEPG2 (liver), HCT116 (colon) and MCF-7 (breast) with a docking study against CDK2

Prospective Comparative Study between Silodosin 8 mg Versus Combination of Tadalafil 5mg and Silodosin 4mgfor treatment of Lower Urinary Tract Symptoms related to Benign Prostatic Hyperplasia

Background:In men, lower urinary tract symptoms (LUTS) are associated with benign prostatichyperplasia (BPH). Therapeutic options aim to relax prostate smooth muscle and/or reduce prostate enlargement. Objectives:To evaluate the efficacy of Silodosin 8 mgalone versus the combinationof Tadalafil 5mg and Silodosin 4 mgfor treatment of LUTS related to BPH. Patients and methods: About 203 patients with LUTS of BPH who completed the study up protocolpresented to our department classified into two groups group A (101 patients) received Silodosin 8 mg, group B (102 patients) received the combination of Tadalafil 5mg and Silodosin 4 mg. All results recorded and analyzed with Statistical Package for Social Science® (SPSS) and Microsoft Excel 2010. Results: The IPSS, QOL, IIEF score, Q-max and PVR showed significantly greater improvement in the combination of Tadalafil 5mg with Silodosin 4mg than monotherapy of Silodosin 8mg. Conclusions:Despite Silodosin 8mg is well-tolerated and effective treatment option in men with LUTS of BPH, butthe combination of tadalafil 5m and Silodosin 4mg is more effective and feasible for these patients