Survival rate of prostate cancer in asian countries: A systematic review and meta-analysis

Background: Prostate cancer is one of the most common health issues among men, especially older men. In recent years, incidences of prostate cancer is increasing. Objective: The aim of this study was to provide a comprehensive estimate of the survival of prostate cancer in Asian countries. Methods: We searched five international databases including Medline/PubMed, Scopus, Embase, Web of Knowledge and ProQuest until June 1, 2018. The Newcastle-Ottawa Quality Assessment was used to evaluate the quality of selected papers. The review protocol was registered in PROSPERO (CRD42019117044). Results: A total of 714 titles were retrieved. Thirty-seven studies met the inclusion criteria. Based on the random-effect model one-year, five-year and ten-year survival rate of prostate cancer were 81 (95 CI 77.8�84.2), 61.9 (95 CI 59.5�64.3) and 36.2 (95 CI 9.2�63.2) respectively. Survival rates based on HDI level for five-year were 30.07, 43.43 and 70.84 percent for medium, high and very high levels, respectively. Conclusion: According to the results of our study, the prostate cancer survival rate in Asian countries is relatively lower than in Europe and North America. © 2020 The Author(s)

The therapeutic role of carotenoids in diabetic retinopathy: A systematic review

Background: Carotenoids are a large group of natural pigments that occur in many foods, fruits, and vegetables. Several studies have shown a number of biological properties of carotenoids, particularly beneficial impacts on cancer, metabolic, neurodegenerative, and cardiovascular diseases. However, recent evidence has shown that these compounds could prevent, delay, and ameliorate diabetic retinopathy (DR). The aim of current study was to review the therapeutic effects of carotenoids in the treatment of DR and discuss the molecular mechanisms that are behind these pharmacological activities. Methods: Six online databases (Medline/PubMed, Scopus, Web of Knowledge, Embase, ScienceDirect, and ProQuest) were searched until September 2019. The systematic review was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Results: A total of 25 studies were included after the final retrieval. A relationship was observed between carotenoids and management of DR. Findings also demonstrated that the underlying mechanism of beneficial effects of these compounds was antioxidant, anti-inflammatory, anti-angiogenic, and neuroprotective properties. Conclusion: Carotenoids potentially delay the initiation and prevent the progression of DR; however, ample preclinical studies are required to confirm their effect, and adequate clinical trials are needed to really understand how well these compounds influence DR among humans. © 2020 Fathalipour et al

The incidence of bladder cancer in Iran: a systematic review and meta-analysis

Objective: There are several reports related to the incidence of bladder cancer (BC) from various geographical locations of Iran. Nevertheless, no comprehensive systematic review has conducted in this regard. Therefore, the present systematic review and meta-analysis carried out to estimate the incidence rate of BC among Iranian people. Patients and Methods: This systematic review was done based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) in October 2017. A search was performed in five international database (Medline/PubMed, Scopus, Embase, ISI/ Web of Science, and Google Scholar), and four national databases (Scientific Information Database, MagIran, Barakat Knowledge Network System, and IranDoc). The incidence rate of BC was calculated using random-effect model. Results: An aggregate of 226 papers was obtained in the primary search of the databases. After further refinement of the retrieved studies, 29 studies were included. The age-standardized rate of BC was 10.92, 95% CI (9.88-11.96) and, 2.80, 95% CI (2.47-3.13) in males and females, respectively. Conclusions: The incidence of BC was lower in Iran compared to other parts of the world. However, more investigations are needed to outline the exact incidence rate and the trend of BC among Iranian population