Gou-Kart (Go UMKM Kart), E-Commerce berbasis Marketplace Untuk Meningkatkan Penjualan dan Pencatatan Keuangan pada UMKM Batik di Bangkalan

Pada saat pandemi banyak UMKM di Indonesia yang mengalami keterbatasan ruang untuk melakukan kegiatan penjualan dikarenakan keterbatasan akan pemahaman mengenai teknologi saat ini. UMKM batik Bangkalan juga terdampak pandemi ini, dimana masih banyak masyarakat yang masih kesulitan untuk memasarkan hasil kerajinan batiknya. Oleh karena itu, perlu adanya Gou-Kart (Go UMKM Kart), e-commerce berbasis marketplace untuk meningkatkan penjualan dan pencatatan keuangan pada UMKM batik di Bangkalan. Gou-Kart ini dibangun menggunakan metode Rapid Application Development (RAD). Metode RAD merupakan metode yang singkat, pendek dan cepat. Gou-Kart ini sangat dibutuhkan oleh penjual batik tulis Madura karena dapat meningkatkan penjualan dan dapat melakukan pencatatan keuangan serta memberikan laporan keuangan laba-rugi

Nephroprotective Effect of N-Acetyl-L-Cysteine against Diazinon-induced Nephrotoxicity in Rats via IKβ, NFκB, NLRP3 Signaling Pathway

The present study analyzes the efficacy of N-acetyl cysteine (NAC) against diazinon (DZN)-induced nephrotoxicity in male Wistar rats. Rats were divided into five groups with six animals in each group: Group 1 (G1) was maintained in typical control circumstances and given saline once daily intragastric (IG) for 4 weeks; G2 was administered 0.1 mL olive oil IG for 4 weeks; G3 was administered IG NAC 150 mg/kg daily as an aqueous solution for 4 weeks; G4 was administered IG diazinon at a dose of 15 mg/kg daily for 4 weeks; and G5 was administered IG NAC daily one hour before diazinon at the same dose in G3 and G4 for 4 weeks. Sub-chronic exposure to DZN impairs the kidney structure and function, as evidenced by the histopathology, immunohistochemistry, and gene expression of NLRP3, NFκB, IKB, BCL2, BAX mRNA. Our findings showed that NAC reduces the renal dysfunctions induced by DZN by restoring urea and creatinine levels as well as oxidative indicators. Moreover, serum inflammatory markers (IL-1β and TNF-α) concentrations were ameliorated by NAC treatment. However, NAC has shown to play a beneficial role against nephrotoxicity by reversing the cytoarchitecture and downregulation of inflammatory (NLRP3, NFκB, IKB) and apoptotic (BAX) as well as upregulated BCL2 genes and proteins in kidney tissues, bringing them to near-normal levels. Moreover, IHC examination of renal tissue revealed the attenuation of expression of TNF-α. Therefore, NAC could be potentially used to protect the kidneys from pathological changes induced by DZN

Oral Administration of Thymoquinone Attenuates Diazinon-induced Renal Injury in Rat: The Involvement of Keap1/Nrf2/HO1/NQO Signaling Pathway

The most prevalent component of the volatile oil found in Nigella sativa seeds is thymoquinone (TQ). As well as being used as food supplements, the seeds and oil are also utilized in traditional medicine to treat a variety of ailments. The purpose of this investigation was to determine whether TQ could protect rats from acute nephrotoxicity caused by diazinon (DZN). Six equal groups of thirty six adult’s male Wistar rats were created at random. Group 1 (G1) was maintained in typical control circumstances and given saline daily intragastric (IG) for 4 weeks; G2 was administered 0.1 mL olive oil IG for 4 weeks; G3 was administered 0.1 mL DMSO IG for 4 weeks; G4 was administered IG TQ at a dose of 10 mg/kg B.W. daily for 4 weeks; G5 was administered IG DZN at a dose of 15 mg/kg B.W. daily for 4 weeks; G6 was administered IG TQ daily one hour before DZN at the same dose in G4 and G5 for 4 weeks. The findings shown that TQ reduces the renal dysfunctions brought on by DZN by restoring urea and creatinine levels as well as oxidative indicators. Although the expression of Keap-1 was also elevated, overexpression of Nrf2 also enhanced the expression of heme oxygenase-1 (HO-1), and NFκB in renal tissue. Also, TQ increased antiapoptotic (BCL2) factors and decrease proapoptotic (BAX) factors. As a result, it is hypothesized that TQ may be helpful in the prevention and management of acute nephrotoxicity brought on by DZN