A new search for R Coronae Borealis stars in the SMC

R Coronae Borealis (RCB) stars are rare, and their evolutionary origin is not well understood. Since they are obscured due to formation of carbon dust around the star during their mass loss events, RCB stars can be classified as self-eclipsing variable stars. The purpose of this work is to present a new search for RCB stars in the Small Magellanic Cloud (SMC), by analysing VI data from the OGLE project

A new search for R Coronae Borealis stars in the SMC

R Coronae Borealis (RCB) stars are rare, and their evolutionary origin is not well understood. Since they are obscured due to formation of carbon dust around the star during their mass loss events, RCB stars can be classified as self-eclipsing variable stars. The purpose of this work is to present a new search for RCB stars in the Small Magellanic Cloud (SMC), by analysing VI data from the OGLE project

Exome sequencing utility in defining the genetic landscape of hearing loss and novel-gene discovery in Iran

Hearing loss (HL) is one of the most common sensory defects affecting more than 466 million individuals worldwide. It is clinically and genetically heterogeneous with over 120 genes causing non-syndromic HL identified to date. Here, we performed exome sequencing (ES) on a cohort of Iranian families with no disease-causing variants in known deafness-associated genes after screening with a targeted gene panel. We identified likely causal variants in 20 out of 71 families screened. Fifteen families segregated variants in known deafness-associated genes. Eight families segregated variants in novel candidate genes for HL: DBH, TOP3A, COX18, USP31, TCF19, SCP2, TENM1, and CARMIL1. In the three of these families, intrafamilial locus heterogeneity was observed with variants in both known and novel candidate genes. In aggregate, we were able to identify the underlying genetic cause of HL in nearly 30% of our study cohort using ES. This study corroborates the observation that high-throughput DNA sequencing in populations with high rates of consanguineous marriages represents a more appropriate strategy to elucidate the genetic etiology of heterogeneous conditions such as HL