14 research outputs found

    Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses

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    Transdermal drug delivery using dissolving microneedles (DMNs) is promising due to increased patient compliance and safety. This article presents a comprehensive simulation and experimental analysis of DMNs with varying tip and base diameters and polymers. The objective of the simulation study is to identify the optimal tip and base diameter of DMNs, as well as the most suitable polymer, for achieving maximum penetration depth. The simulation results showed that the compound consisting of polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) in a ratio of 2:1, with a tip radius of 17.5 μm and a base radius of 150 μm, achieved the deepest penetration among the different types of polymers investigated (including PVA, hyaluronic acid (HA), and PVA/PVP in ratios of 1:1 and 1:2). In addition, mechanical and skin penetration experiments were performed on PVA/PVP 2:1 DMNs with varying concentrations of 4, 7, 10, and 15% w/w to determine the optimal polymer concentration. The results of this study indicated that the optimal composition, considering the viscosity of the polymer solution and the simplicity of filling the silicone negative molds, is a PVA/PVP 2:1 with a concentration of 7% w/w

    Why has the taxing policy on sugar sweetened beverages not reduced their purchase in Iranian households?

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    ObjectiveThis study aimed at analyzing the effectiveness of the policy of taxing Sugar-Sweetened Beverages (SSBs) on their purchases during the last decade in Iranian households.MethodsThe present mixed method study was done in 2017 in four phases: (1) A meta-review of the fiscal policies during the last decade, (2) Collecting existing data on soft drinks’ production, price, and household expenditure during the last decade, (3) Conducting 19 semi-structured interviews with key informants, and (4) Facilitating a national meeting to achieve a consensus on the recommendations and future implications.ResultsDocument reviews showed that based on the Permanent Provisions of National Development Plans of Iran, the Ministry of Health and Medical Education (MOHME) should announce the list of health threatening products to increase taxation for them. The government is allowed to impose taxes on domestically produced and imported SSBs. The average household expenditure on SSBs increased in the rural and urban households of Iran during 2006–2016 in spite of taxation. In the different key informants’ opinion, only value-added tax (VAT) was implemented among different fiscal policies, and the other parts, including tax and tolls were debated.ConclusionThe present research findings further proposed some suggestions for increasing the effectiveness of financial policies in reducing the prevalence of NCDs in Iran

    Need for Couple’s Awareness About Sexual Health in COVID-19 Pandemic

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    Poly(3-hydroxybutyrate) Production from Natural Gas by a Methanotroph Native Bacterium in a Bubble Column Bioreactor

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    Reducing the total cost of poly(3-hydroxybutyrate) (PHB) production as an attractive substitute for conventional petrochemical plastics still remains an unsolved problem. The aim of this research was the screening of PHB-producing microorganisms and selection of the best suitable medium for microbial growth and PHB production from methane. A new isolated methanotroph for PHB production from natural gas was studied in different media. After selection of the suitable medium, the effect of five process variables (content of nitrogen source, disodium hydrogen phosphate, methane to air ratio, seed age, and pH) on PHB production was investigated in a bubble column bioreactor. Also, hydrodynamic and mass transfer factors (flow regime, mixing time, gas hold up, and kLa) were considered. At optimum operating conditions and engineering parameters in a bubble column, PHB content in the dried biomass reached 25 % w/w. The results showed that pH is the most important variable in the selected conditions.</jats:p

    Emotional and Behavioral Problems of Afghan Refugees and War-Zone Adolescents

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    "nObjective: Wars&apos; stress and violence can have tremendous effects on children&apos;s and adolescents&apos; health and general well being; it may result in patterns of bio-psychosocial problems. The goal of this study was to compare emotional and behavioral problems in Afghan refugees and war-zone adolescents. "n Method: One hundred and eighty high school students (90 students in the refugee group and 90 in the war-zone group) in Harat were included in this research. All participants completed the Youth Self-Report (YSR). War zone and refugee adolescents were compared based on their scores on different scales of behavioral and emotional problems. "n Results: War-zone adolescents scored significantly higher on Anxious/Depression, Withdrawn, Somatic Complaints, Attention Problems, and Internalizing Problems scales than refugee adolescents. In this study, no significant difference was found between the two groups on Social Problems, Thought Problems, Delinquent Behavior, Aggressive Behavior, and Externalizing scales. "nConclusion: Findings revealed that although asylum is not an ideal condition for children&apos;s and adolescents&apos; psychological development and prosperity, it can have a protective role in comparison with war zone&apos;s circumstances. Further investigation is needed, however, to elucidate the lack of significant differences in externalizing scales among war zone and refugee adolescent
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