Effective wound healing agents based on N-alkenylimidazole zinc complexes derivatives: future prospects and opportunities

The aim of the study: to provide experimental evidence for effects of recently developed zinc complexes with N-alkenylimidazole as wound healing agent

Determining the Parameters of Massive Protostellar Clouds via Radiative Transfer Modeling

A one-dimensional method for reconstructing the structure of prestellar and protostellar clouds is presented. The method is based on radiative transfer computations and a comparison of theoretical and observed intensity distributions at both millimeter and infrared wavelengths. The radiative transfer of dust emission is modeled for specified parameters of the density distribution, central star, and external background, and the theoretical distribution of the dust temperature inside the cloud is determined. The intensity distributions at millimeter and IR wavelengths are computed and quantitatively compared with observational data. The best-fit model parameters are determined using a genetic minimization algorithm, which makes it possible to reveal the ranges of parameter degeneracy as well. The method is illustrated by modeling the structure of the two infrared dark clouds IRDC-320.27+029 (P2) and IRDC-321.73+005 (P2). The derived density and temperature distributions can be used to model the chemical structure and spectral maps in molecular lines.Comment: Accepted for publication in Astronomy Report

Melting of tantalum at high pressure determined by angle dispersive x-ray diffraction in a double-sided laser-heated diamond-anvil cell

The high pressure and high temperature phase diagram of Ta has been studied in a laser-heated diamond-anvil cell (DAC) using x-ray diffraction measurements up to 52 GPa and 3800 K. The melting was observed at nine different pressures, being the melting temperature in good agreement with previous laser-heated DAC experiments, but in contradiction with several theoretical calculations and previous piston-cylinder apparatus experiments. A small slope for the melting curve of Ta is estimated (dTm/dP = 24 K/GPa at 1 bar) and a possible explanation for this behaviour is given. Finally, a P-V-T equation of states is obtained, being the temperature dependence of the thermal expansion coefficient and the bulk modulus estimated.Comment: 31 pages, 8 figures, to appear in J.Phys.:Cond.Matte

Experience with the use of virus-neutralizing antibodies in coronavirus infection

The aim of the study – to evaluate the effectiveness of virus-neutralizing monoclonal antibodies in the treatment of coronavirus infectionЦель работы - оценить эффективность вируснейтрализующих моноклональных антител при лечении коронавирусной инфекци

DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS

Taking into account the current Product specification file, the aim of the work was to develop the composition and technology for obtaining effervescent tablets based on solid dispersions of furazolidone in the form of an aqueous solution for external use.Materials and methods. The used substances were: furazolidone, anhydrous sodium carbonate (chemically pure), polyvinylpyrrolidone-24000±2000 (chemically pure), malic acid (analytically pure), tartaric acid (chemically pure), citric acid (chemically pure), sodium benzoate (chemically pure), ethyl alcohol 96% (chemically pure), purified water. Preparation of granulates is separate wet granulation in a fluidized bed (Mycrolab, BOSCH, Germany). Obtaining tablets is the process of pressing on a manual hydraulic test press ("PRG", VNIR, Russia). The dependence of disintegration, abrasion capacity and crushing resistance on compacting pressure was investigated. Technological parameters of granulates, еру obtained effervescent tablets, shelf life and storage conditions were investigated according to the State Pharmacopoeia of the Russian Federation XIVth ed.Results. Two compositions of effervescent tablets containing solid dispersions of furazolidone as an active substance were obtained, which, when dissolved in 100 ml of water at room temperature (20°C), form a solution of furazolidone with a concentration of 0.004% in less than 5 minutes. The method of quantitative determination of the furazolidone content in the effervescent tablets was validated. A complex of physicochemical methods for the analysis of tablets was carried out. Quality standards have been developed. The developed compositions stability of instant tablets during storage during accelerated and long-term tests has been experimentally confirmed. The preliminary shelf life and storage conditions have been determined.Conclusion. The result of technological and chemical-pharmaceutical research is the creation and evaluation of the quality of a new instant furazolidone dosage form as effervescent tablet formulations

Assessment of public health of production workers according to HRV

The study of the social health of labour resources as human capital is an actual problem. In production workers, the vegetative status was studied in terms of heart rate variability. By the concept of autonomic reactivity A.M. Greenberg, the results of the study found that the vegetative status of male employees and workers differs. The employees performing functions related to the organization of the production process showed general sympathicotonia. Workers performing specific production tasks have a general sympathicotonia. The results of the study found that vegetative status makes it possible to assess the social health of production workers. In the context of the intensive introduction of neural networks and nanotechnology into industrial production, the number of employees will increase. As a result, there will be an increase in the likelihood of cardio-respiratory system diseases among this contingent of workers. This will entail the development of corrective programs for the prevention of diseases of the cardiovascular system, and the introduction of changes in the classifier of occupational diseases. © 2020 The Authors, published by EDP Sciences

Assessment of driver biorhythms as a factor of labor safety

The paper provides a biorhythmological assessment of the health of a driver's team in conditions of joint activity in terms of heart rate variability. Measurements were taken during the working day using Holter monitoring in AnnaFlash2000 software and statistical processing ISCIM6. The cardiogram of the heart was recorded during the working day from 8.00 to 18.00 hours. It was revealed that the rhythmic processes of acrophase and heart rate bathyphase, which testify to the leading role of hypoxia, hypercapnia and desynchronosis of ultradian rhythms, influence the joint professional activity of drillers. The examined drivers found a violation of the synchronization of biological rhythms and desynchronosis at various levels of regulation of heart rhythm regulation. Both drivers, working in different biological rhythms, have a low degree of compatibility and belong to the group of production risk, which negatively affects occupational safety. © The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/)

Layer intermixing in ultrathin Cr/Be layered system and impact of barrier layers on interface region

Chemical composition and significance of the interfaces in Cr/Be layered structures depending on the thickness and ordering of beryllium and chromium layers were considered in details. Absence of pure Be and Cr layers and the formation of two beryllides, CrBe$_{12}$ and CrBe$_2$, depending on the order of layer deposition was established in the systems with layer thickness less than 2.0 nm. This fact indicates a strong layer intermixing and is explained by both the ballistic layer intermixing and surface-free energy minimization processes. Insertion of an ultrathin barrier layer (Si, C, B$_4$C) between the ultrathin base layers simultaneously affects the formation of both interfaces. In the case of such ultrathin multilayer systems, the task of specific interface engineering by a barrier layer insertion appears to become much more complicated due to the strong layer intermixing occurring through the deposition process and further diffusion. Both interfaces are inseparable and a chemical change in one inevitably causes a chemical change in the second