Development and psychometric evaluation of the Persian version of the Phoneme Recognition Test A central auditory processing measure

  Objectives The present study evaluating the psychometric properties of the Persian version of the Phoneme Recognition Test (P-PRT) in normal subjects and cochlear implant (CI) users. Material & Methods This study includes developing the Persian phoneme recognition test (PRT), determining its validity and reliability, and comparing the results of a control group versus CI users. The test reliability was examined through a test-retest with an approximately five-week interval. In the present survey, 363 subjects were investigated in three stages. The face validity evaluation stage was conducted on 40 subjects. The psychometric properties of the P-PRT were evaluated in 323 individuals (225 normal subjects and 98 CI users). The test-retest reliability was examined in all the 225 subjects in the control groupand 40 CI users. ResultsThe results confirmed the face validity of the P-PRT. No significant differences were observed between the two genders in terms of performance in the P-PRT. Significant differences were observed between the control and CI groups. Evaluating the test-retest reliability suggested perfect reliability (r>0.9) in both groups. Significant differences were observed in the P-PRT between the adults and the 7-year-old subjects compared to other age groups. Conclusion The P-PRT can be used as a valid and reliable test for clinically evaluating phoneme recognition abilities and monitoring the rehabilitation progres

The Effect of a Words-in-Noise Training Method on Speech Perception in Noise of Children with Unilateral Hearing Loss

Background and Aim: Despite more affordable and advanced technologies for early detection of congenital hearing loss, unilateral hearing loss is the prevalent form of hearing loss affecting school-aged children. This study aimed to examine the impact of Words-in-Noise (WIN) training on speech perception of noise in children with unilateral hearing loss. Methods: Thirteen children aged 8 to 12 years with unilateral hearing loss underwent a WIN training program in noise. The participants were tested before and after training on word identification in noise and cortical auditory evoked potentials. Results: A comparison of the mean signal-to-noise ratio 50% between pre- and post-training indicated that signal-to-noise ratio 50% score decreased after training sessions. WIN training reduced the latency in N1 and P2 waves in the Fz electrode and the N1 wave in the Pz electrode and increased the amplitude of the waves in the Fz and Pz electrodes. The observed data suggest that all participants’ performance improved on word identification in noise and some electrophysiological parameters. Cortical auditory evoked potentials components changes did not correlate with the WIN scores. Conclusion: The Persian version of the WIN training improved speech perception ability in the presence of competitive noise in children with unilateral hearing loss. Therefore, this software solution can partially solve speech comprehension problems with noise in these children

Comparison of the Ling-6 Sound Test with Warble Tone Stimuli in Audiometry of Hearing-Impaired Children Using Hearing Aids Considering Different Prescriptions and Normal-Hearing Children

Background and Aim: Speech is a vital stimulus and the ultimate goal of hearing aid fitting to make the speech an audible signal. The purpose of this research was to investigate whether it is possible to track the threshold with speech phonemes and which of the two fitting methods of Desired Sensation Level version 5.0 (DSL v5.0) and National Acoustic Laboratories-Nonlinear 2 (NAL-NL2) provide better audibility for the phonemes. Methods: In this cross-sectional study, the unaided thresholds of 18 normal-hearing children and the aided thresholds of 15 hearing-impaired children aged 5-8 years were evaluated with two types of stimuli. DSL v5.0 and NAL-NL2 methods were used for hearing aid fitting in hearing-impaired children. Results: There was a significant relationship between the unaided and aided thresholds of each phoneme and the warble tone threshold at the corresponding frequency (p<0.01), except for the phoneme /s/. The results showed a significant difference between the aided thresholds of each phoneme and the upper limit of the speech banana in the corresponding frequency for each method (Z=–4.99, p≤0.001). Conclusion: The results showed that phonemes could be used to assess unaided and aided thresholds. In the first fit, both methods estimated the amount of amplification that caused the average aided thresholds for these six phonemes for moderate to severe hearing loss to be positioned within the speech banana range, except for the average aided thresholds for the /s/ phoneme in the NAL-NL2 method that was placed outside the range

Developing Persian Quick Speech in Noise With Words Containing High Frequency Phonemes: Determining its Validity and Equivalency

Background and Aims The quick speech in noise (Q-SIN) test shows how difficult it is to perceive speech in noise by determining signal-to-noise ratio (SNR) loss. The lists with high-frequency words have a better ability to identify SNR loss which have been created in Persian. Although a Persian version of Q-SIN with emphasis on high frequency is available، but there is no Q-SIN lists with high-frequency words; therefore,this study aims to develop new lists and the lists with high-frequency words for Q-SIN test and determine their equivalency in normal-hearing people which was condcuted in Tehran University of Medical Sciences.Methods The sentences were first developed. Then, their content validity and face validity were determined. In this regard، 36 sentences were used to make new Q-SIN lists and 36 sentences were used to make Q-SIN lists with high-frequency words. Based on the Q-SIN test development criteria، six regular lists (lists 1-6) and six lists with high-frequency words (lists 7-12) were tested on 46 people (23 males and 23 females) aged 18-35 with normal hearingResults The content validity index for new and high-frequency words lists were 0. 74 and 0. 736، respectively. The equivalency test results showed that among the first 6 lists، the lists no. 1, 2, 3, and 4 were equal. Among the six lists with high-frequency words, the lists no. 7, 8, 10, 11 were equal. There was no gender differences between six regular lists and high-frequency lists (P>0.05). Conclusion The Q-SIN word lists with equivalency can be used for normal-hearing people in clinical practice

Identification of blaCTX-M, blaSHV, and blaTEM Genes in Pseudomonas Aeruginosa Strains Isolated from Human and Animal Samples Using Multiplex-PCR Method

Background and Objectives: Pseudomonas aeruginosa is one of the most important causes of opportunistic infections. The infection caused by P. aeruginosa is commonly severe and life-threatening and hard to treat due to limited susceptibility to antibiotics and development of resistance during treatment. The aim of the present study was to identify blaCTX-M, blaSHV, and blaTEM genes in P. &lrm;aeruginosa strains isolated from human and animal samples using Multiplex-PCR method.&lrm; Methods: In this descriptive cross-sectional study, a total of 120 isolates of P. aeruginosa were obtained from of human samples and animal raw milk. Antibiotic susceptibility test was determined by gel diffusion method and according to CLSI guidelines. Cellular DNA was extracted by CinnaPure-DNA (Cell culture, Tissues, Gram-negative Bacteria and CSF) and Multiplex-PCR was performed for identification of blaCTX-M, blaSHV, and blaTEM genes. Results: In this study, the highest resistance in human and animal samples, was seen to amoxicillin and amikacin (100%) &lrm;and the lowest resistance was to ciprofloxacin with frequency of 90% in human &lrm;samples and 93.4% in animal samples. Based on the CDT results, 37(60.8%) isolates showed ESBLs phenotype, and based on the M-PCR results, 26 &lrm;&lrm;(21.6%) and 41 (34.2%) strains had blaCTX-M and blaTEM genes, respectively. Conclusion: The results of this study indicated that P. aeruginosa strains have high levels of resistance. Also, the frequency of these genes is high among human and animal isolates, therefore controlling these bacteria in humans and animals is of particular importance

A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model?

Background: Cisplatin (CP) is widely used in clinic to treat the solid tumors. However, CP is associated with some major side effects including nephrotoxicity, hepatoxicity, and testicular toxicity. Objectives: To found, which of the toxicities is the first side effect of CP. Materials and Methods: we conducted a pilot research on 12 adult male Wistar rats. Results: One week after CP administration, the induced toxicity was observed clearly in kidney tissue. The only abnormality that observed in testis tissue was very small degree of hyaline casts. However, no damage and other abnormality were detected in the liver tissue. Conclusions: According to these findings, in clinic, first special attention must be made on kidneys during chemotherapy with CP. However, the duration of experiment is suggested to be extended to obtain hepatoxicity or testicular toxicity model in experimental animal in laboratories. Moreover, different dose of CP should be used to study the first side effect in animal model