Is the Detection of Accelerated Sea Level Rise Imminent?

Global mean sea level rise estimated from satellite altimetry provides a strong constraint on climate variability and change and is expected to accelerate as the rates of both ocean warming and cryospheric mass loss increase over time. In stark contrast to this expectation however, current altimeter products show the rate of sea level rise to have decreased from the first to second decades of the altimeter era. Here, a combined analysis of altimeter data and specially designed climate model simulations shows the 1991 eruption of Mt Pinatubo to likely have masked the acceleration that would have otherwise occurred. This masking arose largely from a recovery in ocean heat content through the mid to late 1990 s subsequent to major heat content reductions in the years following the eruption. A consequence of this finding is that barring another major volcanic eruption, a detectable acceleration is likely to emerge from the noise of internal climate variability in the coming decade

Are GRACE-era Terrestrial Water Trends Driven by Anthropogenic Climate Change?

To provide context for observed trends in terrestrial water storage (TWS) during GRACE (2003–2014), trends and variability in the CESM1-CAM5 Large Ensemble (LE) are examined. Motivated in part by the anomalous nature of climate variability during GRACE, the characteristics of both forced change and internal modes are quantified and their influences on observations are estimated. Trends during the GRACE era in the LE are dominated by internal variability rather than by the forced response, with TWS anomalies in much of the Americas, eastern Australia, Africa, and southwestern Eurasia largely attributable to the negative phases of the Pacific Decadal Oscillation (PDO) and Atlantic Multidecadal Oscillation (AMO). While similarities between observed trends and the model-inferred forced response also exist, it is inappropriate to attribute such trends mainly to anthropogenic forcing. For several key river basins, trends in the mean state and interannual variability and the time at which the forced response exceeds background variability are also estimated while aspects of global mean TWS, including changes in its annual amplitude and decadal trends, are quantified. The findings highlight the challenge of detecting anthropogenic climate change in temporally finite satellite datasets and underscore the benefit of utilizing models in the interpretation of the observed record

Black carbon aerosols and the third polar ice cap

Recent thinning of glaciers over the Himalayas (sometimes referred to as the third polar region) have raised concern on future water supplies since these glaciers supply water to large river systems that support millions of people inhabiting the surrounding 5 areas. Black carbon (BC) aerosols, released from incomplete combustion, have been increasingly implicated as causing large changes in the hydrology and radiative forcing over Asia and its deposition on snow is thought to increase snow melt. In India BC from biofuel combustion is highly prevalent and compared to other regions, BC aerosol amounts are high. Here, we quantify the impact of BC aerosols on snow cover and pre10 cipitation from 1990 to 2010 over the Indian subcontinental region using two different BC emission inventories. New estimates indicate that Indian BC from coal and biofuel are large and transport is expected to expand rapidly in coming years. We show that over the Himalayas, from 1990 to 2000, simulated snow/ice cover decreases by ~0.9% due to aerosols. The contribution of the enhanced Indian BC to this decline is ~30%, 15 similar to that simulated for 2000 to 2010. Spatial patterns of modeled changes in snow cover and precipitation are similar to observations (from 1990 to 2000), and are mainly obtained with the newer BC estimates

The Maunder minimum and the Little Ice Age: an update from recent reconstructions and climate simulations

The Maunder minimum (MM) was a period of extremely low solar activity from approximately AD 1650 to 1715. In the solar physics literature, the MM is sometimes associated with a period of cooler global temperatures, referred to as the Little Ice Age (LIA), and thus taken as compelling evidence of a large, direct solar influence on climate. In this study, we bring together existing simulation and observational studies, particularly the most recent solar activity and paleoclimate reconstructions, to examine this relation. Using northern hemisphere surface air temperature reconstructions, the LIA can be most readily defined as an approximately 480 year period spanning AD 1440–1920, although not all of this period was notably cold. While the MM occurred within the much longer LIA period, the timing of the features are not suggestive of causation and should not, in isolation, be used as evidence of significant solar forcing of climate. Climate model simulations suggest multiple factors, particularly volcanic activity, were crucial for causing the cooler temperatures in the northern hemisphere during the LIA. A reduction in total solar irradiance likely contributed to the LIA at a level comparable to changing land use

Thrombolysis for massive pulmonary embolism in pregnancy: a case report

Mortality from pulmonary embolism (PE) in pregnancy might be related to challenges in targeting the right population for prevention. Such targeting could help ensure that the correct diagnosis is suspected and adequately investigated, and allow the initiation of the timely and best possible treatment of this disease. In the literature to date only 18 case reports of thrombolysis in pregnant women with PE have been reported, and showed beneficial effects for both mother and fetus in terms of mortality and complications with acceptable bleeding risks. We present here the case of a pregnant patient with massive PE who underwent successful thrombolysis. A 26-year-old pregnant (at 24 weeks) woman was admitted 4 h after onset of sudden acute dyspnea and chest pain. An immediate electrocardiogram showed a typical S1-Q3-T3 pattern. The echocardiogram showed a distended right ventricle with free-wall hypokinesia and displacement of the interventricular septum toward the left ventricle. Thrombolysis with recombinant tissue plasminogen activator (alteplase 10 mg bolus, then 90 mg over 2 h) was administered. Pelvic examination and ultrasound showed regular fetal heart beat, and regular placental and liquid presence. No problems developed for the mother or fetus in the subsequent days or at discharge. In conclusion, in pregnant patients with life-threatening massive PE, thrombolytic therapy can be administered, and the use of echocardiographic, laboratory, and clinical data can be useful tools to achieve a rapid diagnosis and make a therapeutic decision, but additional studies need to be performed to further define its use

Asymmetric Response of Land Storage to ENSO Phase and Duration

Emergence of global mean sea level (GMSL) from a 'hiatus' following a persistent La Ni&ntilde;a highlights the need to understand the causes of interannual variability in GMSL. Several studies link interannual variability in GMSL to anomalous transport of water mass between land and ocean-and subsequent changes in water storage in these reservoirs-primarily driven by El Ni&ntilde;o/Southern Oscillation (ENSO). Despite this, asymmetries in teleconnections between ENSO mode and land water storage have received less attention. We use historical simulations of natural climate variability to characterize asymmetries in the hydrological response to ENSO based on phase and duration. Findings indicate pronounced phase-specific and duration-specific asymmetries covering up to 93 and 50 million km2 land area, respectively. The asymmetries are seasonally dependent, and based on the mean regional climate are capable of influencing inherently bounded storage by pushing the storage-precipitation relationship towards nonlinearity. The nonlinearities are more pronounced in dry regions in the dry season, wet regions in the wet season, and during Year 2 of persistent ENSO events, limiting the magnitude of associated anomalies under persistent ENSO influence. The findings have implications for a range of stakeholders, including sea level researchers and water managers.</p

Use of bivalirudin for heparin-induced thrombocytopaenia after thrombolysis in massive pulmonary embolism: a case report

A 68-year-old man was referred to the emergency department 6 h after onset of sudden acute dyspnoea. Immediate ECG showed sinus tachycardia with the typical S1-Q3-T3 pattern and incomplete right bundle branch block. The echocardiogram showed the presence of mobile thrombus in the right atrium, a distended right ventricle with free wall hypokinesia and displacement of the interventricular septum towards the left ventricle. Lung spiral computed tomography (CT) showed bilateral pulmonary involvement and confirmed the picture of a thrombotic system in the right atrium and caval vein. Thrombolytic treatment with recombinant tissue plasminogen activator (rt-PA) and heparin (alteplase 10 mg bolus, then 90 mg over 2 h) was administered. Six hours after thrombolysis bleeding gums and significant reduction in platelet count (around 50,000) were observed. Heparin was discontinued and bivalirudin (0.1 mg/kg bolus and 1.75 mg/kg per h infusion) plus warfarin was initiated and continued for 5 days until the international normalised ratio (INR) was within the therapeutic range (2.0–3.0) for 2 consecutive days, with concomitant platelet count normalisation. Lung spiral and lower abdominal CT before discharge did not show the presence of clots in the pulmonary arteries of the right and left lung. This case suggests that bivalirudin could offer promise for use in patients with heparin-induced thrombocytopaenia (HIT) after thrombolysis for massive pulmonary embolism

CESM1(WACCM) Stratospheric Aerosol Geoengineering Large Ensemble Project

This paper describes the Stratospheric Aerosol Geoengineering Large Ensemble (GLENS) project, which promotes the use of a unique model dataset, performed with the Community Earth System Model, with the Whole Atmosphere Community Climate Model as its atmospheric component [CESM1(WACCM)], to investigate global and regional impacts of geoengineering. The performed simulations were designed to achieve multiple simultaneous climate goals, by strategically placing sulfur injections at four different locations in the stratosphere, unlike many earlier studies that targeted globally averaged surface temperature by placing injections in regions at or around the equator. This advanced approach reduces some of the previously found adverse effects of stratospheric aerosol geoengineering, including uneven cooling between the poles and the equator and shifts in tropical precipitation. The 20-member ensemble increases the ability to distinguish between forced changes and changes due to climate variability in global and regional climate variables in the coupled atmosphere, land, sea ice, and ocean system. We invite the broader community to perform in-depth analyses of climate-related impacts and to identify processes that lead to changes in the climate system as the result of a strategic application of stratospheric aerosol geoengineering

Msh2 Blocks an Alternative Mechanism for Non-Homologous Tail Removal during Single-Strand Annealing in Saccharomyces cerevisiae

Chromosomal translocations are frequently observed in cells exposed to agents that cause DNA double-strand breaks (DSBs), such as ionizing radiation and chemotherapeutic drugs, and are often associated with tumors in mammals. Recently, translocation formation in the budding yeast, Saccharomyces cerevisiae, has been found to occur at high frequencies following the creation of multiple DSBs adjacent to repetitive sequences on non-homologous chromosomes. The genetic control of translocation formation and the chromosome complements of the clones that contain translocations suggest that translocation formation occurs by single-strand annealing (SSA). Among the factors important for translocation formation by SSA is the central mismatch repair (MMR) and homologous recombination (HR) factor, Msh2. Here we describe the effects of several msh2 missense mutations on translocation formation that suggest that Msh2 has separable functions in stabilizing annealed single strands, and removing non-homologous sequences from their ends. Additionally, interactions between the msh2 alleles and a null allele of RAD1, which encodes a subunit of a nuclease critical for the removal of non-homologous tails suggest that Msh2 blocks an alternative mechanism for removing these sequences. These results suggest that Msh2 plays multiple roles in the formation of chromosomal translocations following acute levels of DNA damage

Regional Hydroclimate Response to Stratospheric Sulfate Geoengineering and the Role of Stratospheric Heating

Geoengineering methods could potentially offset aspects of greenhouse gas‐driven climate change. However, before embarking on any such strategy, a comprehensive understanding of its impacts must be obtained. Here, a 20‐member ensemble of simulations with the Community Earth System Model with the Whole Atmosphere Community Climate Model as its atmospheric component is used to investigate the projected hydroclimate changes that occur when greenhouse gas‐driven warming, under a high emissions scenario, is offset with stratospheric aerosol geoengineering. Notable features of the late 21st century hydroclimate response, relative to present day, include a reduction in precipitation in the Indian summer monsoon, over much of Africa, Amazonia and southern Chile and a wintertime precipitation reduction over the Mediterranean. Over most of these regions, the soil desiccation that occurs with global warming is, however, largely offset by the geoengineering. A notable exception is India, where soil desiccation and an approximate doubling of the likelihood of monsoon failures occurs. The role of stratospheric heating in the simulated hydroclimate change is determined through additional experiments where the aerosol‐induced stratospheric heating is imposed as a temperature tendency, within the same model, under present day conditions. Stratospheric heating is found to play a key role in many aspects of projected hydroclimate change, resulting in a general wet‐get‐drier, dry‐get‐wetter pattern in the tropics and extratropical precipitation changes through midlatitude circulation shifts. While a rather extreme geoengineering scenario has been considered, many, but not all, of the precipitation features scale linearly with the offset global warming