3 research outputs found
Asymmetric Michael Addition of Dimethyl Malonate to 2 Cyclopenten-1-one Catalyzed by a Heterobimetallic Complex
A. Preparation of GaNa-(S)-BINOL((S)-2) Solution (0.05 M).2 A flame-dried 1L, three-necked round-bottomed flask with 24/40 joints and a 1.5" Teflon coated egg-shaped magnetic stir bar is brought into a nitrogen filled glovebox (Note 2). The flask is charged with gallium (III) chloride (5.0 g, 28.4 mmol, 1.0 equiv) (Notes 3 and 4). The flask is sealed with three rubber septa (one of which is fitted with an internal temperature probe) brought out of the glovebox, and put under positive pressure of nitrogen via a needle attached to a nitrogen line. Another flame-dried 1L, three-necked round-bottomed flask with 24/40 joints and a 1.5" Teflon coated egg-shaped magnetic stir bar is charged with (S)-(-)-1,1'-bi(2-naphthol) ((S)-BINOL, (S)-1) (16.26 g, 56.8 mmol, 2.0 equiv) (Note 5). The flask is sealed with three rubber septa (one of which is fitted with a thermometer) and evacuated and backfilled with nitrogen three times (5 minutes under vacuum per cycle). A flame-dried 500 mL round-bottomed flask with a 24/40 joint and a 1" Teflon coated egg-shaped magnetic stir bar is charged with sodium tert -butoxide (10.92 g, 113.6 mmol, 4.0 equiv) (Note 6). The flask is sealed with a rubber septum and evacuated and backfilled with nitrogen three times (5 minutes under vacuum per cycle)
Biphilic Organophosphorus Catalysis: Regioselective Reductive Transposition of Allylic Bromides via P<sup>III</sup>/P<sup>V</sup> Redox Cycling
We
report that a regioselective reductive transposition of primary
allylic bromides is catalyzed by a biphilic organophosphorus (phosphetane)
catalyst. Spectroscopic evidence supports the formation of a pentacoordinate
(σ<sup>5</sup>-P) hydridophosphorane as a key reactive intermediate.
Kinetics experiments and computational modeling are consistent with
a unimolecular decomposition of the σ<sup>5</sup>-P hydridophosphorane
via a concerted cyclic transition structure that delivers the observed
allylic transposition and completes a novel P<sup>III</sup>/P<sup>V</sup> redox catalytic cycle. These results broaden the growing
repertoire of reactions catalyzed within the P<sup>III</sup>/P<sup>V</sup> redox couple and suggest additional opportunities for organophosphorus
catalysis in a biphilic mode