Fatal encephalitis associated with novel influenza A (H1N1) virus infection in a child

A 4-year-old girl presented with fever, coughing, and vomiting; followed by unconsciousness. Magnetic resonance imaging showed hyperintense changes in the thalami bilaterally, brain stem, cerebellum, and subcortical cortex. Novel influenza A (H1N1) virus was identified by polymerase chain reaction in patient’s nasopharyngeal swab specimen. We reported a rare case of clinically severe, novel influenza A-associated encephalitis. Novel influenza A should be considered in the differential diagnosis in patients with seizures and mental status changes, especially during an influenza outbreak

İlk iki yıl içinde nöbeti başlayan epileptik çocuklarda prognoızu etkileyen faktörler

TEZ3856Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 2002.Kaynakça (s. 62-65) var.vi, 65 s. ; 30 cm.

A patient with left hemiparesis, seizure, and developmental delay on admission Reply

WOS: 000269907200027

The factors associated with first antiepileptic drug response in patients with idiopathic epilepsy.

TEZ10201Tez (Yandal Uzmanlık) -- Çukurova Üniversitesi, Adana, 2013.Kaynakça (s. 59-64) var.ix, 67 s. : tablo ; 29 cm.Amaç: Bu retrospektif çalışmanın amacı, yeni tanı konulan sentrotemporal dikenli benign çocukluk çağı ve çocukluk çağı absans epilepsisi hastalarda ilk antiepileptik ilaç tedavisine cevabı belirleyen faktörleri saptamaktır. Gereç ve Yöntem: Bu çalışmada yüz otuz bir hastanın verileri retrospektif olarak değerlendirildi. Çalışma grubu 79 sentrotemporal dikenli benign çocukluk çağı epilepsili hasta ve 52 çocukluk çağı absans epilepsili hastadan oluşmaktaydı. Bulgular: Sentrotemporal dikenli benign çocukluk çağı epilepsili hastalarda ortalama nöbet başlama yaşı 89.44 ± 25.59 ay (36-143 ay) ve 50?si (% 63,3) erkek idi. İlk antiepileptik ilaç tedavisiyle 68 (% 86,1) hastada nöbet kontrolü sağlandı. Nöbet başlama yaşı, nöbet sıklığı, nöbet tipi ve EEG?deki deşarj noktası ilk ilaç tedavisine cevabı belirleyen önemli bir faktör olmasına rağmen, cinsiyet, yenidoğan nöbet varlığı, febril nöbet, ailede epilepsi öyküsü, nöbet zamanı, Todd paralizisi varlığı, ZB düzeyi, davranış sorunlarının varlığı, EEG?de jeneralizasyon ve lokalizasyon bulguları tedaviyi belirlemede etkisiz faktörlerdi. Çocukluk çağı absans epilepsili hasta grubunda nöbet başlama yaşı ortalama 78.38 ± 26.09 ay (30-142 ay) ve 32?si (% 61,5) kız idi. Kırk iki (% 80,8) hasta ilk antiepileptik ilaçla başarılı bir şekilde tedavi edildi. Cinsiyet, yenidoğan nöbeti varlığı, febril konvülziyon, akrabalık, ailede epilepsi öyküsü, ZB seviyesi, tedaviye başlangıç zamanı ve EEG?deki deşarj şekli ile ilk ilaç tedavisine cevap arasında anlamlı bir ilişki bulunmadı. Ancak, nöbet başlama yaşı, eşlik eden nöbet tipi ve EEG?de fotik yanıt varlığı başlangıç tedavisine cevabı belirlemede önemli faktörler olarak bulunmuştur. Sonuç: Nöbet başlama yaşı, nöbet tipi, nöbet sıklığı ve EEG'de deşarj noktası sentrotemporal dikenli benign çocukluk çağı epilepsisi olan hastalarda önemli faktörler olarak bulunmuştur. Çocukluk absans epilepsili hastalarda, nöbet başlama yaşı, eşlik eden nöbet tipi ve EEG?de fotik yanıt varlığı başlangıç tedavisine yanıt için önemli risk faktörleridir.Aim: The aim of this retrospective study was to determine the risk factors associated with initial antiepileptic drug response in children newly diagnosed with idiopathic childhood absence epilepsy and benign childhood epilepsy with centrotemporal spikes. Materials and Methods: One hundered and thirty one patient?s datas were analyzed for retrospective in this study. The study group consisted of 79 patients with benign childhood epilepsy with centrotemporal spikes and 52 patients with childhood absence epilepsy. Results: In benign childhood epilepsy with centrotemporal spikes group, the mean age of onset seizure was 89.44 ± 25.59 months (range: 36-143 months) and 50 (63.3%) were male. Treatment with first drug led to seizure freedom in 68 (86.1%) patients. Although age at onset of seizures, type of seizure, seizure frequency and focus in EEG were an important risk factors for response to first drug, sex, neonatal seizure, febrile convulsions, family history of epilepsy, time of seizure, Todd paralysis, presence of a behavior problems, ZB level, age at onset of therapy, generalization and localization in EEG were not significant. In childhood absence epilepsy group, the mean age was 78.38 ± 26.09 months (range: 30-142 months) and 32 (61.5%) were female. 42 patients (80.8%) were treated successfully for the first drug. There was no correlation between success of initial drug therapy and sex, neonatal seizure, febrile convulsions, family history of seizures, ZB level, age at onset of therapy, and type of discharge in EEG. However, age at onset of seizures, coexisting seizure types, and photoconvulsive response in EEG were significant the factors for response to initial treatment. Conclusion: Age at onset of seizures, type of seizure, seizure frequency and focus in EEG was found to be important factors in patients with benign childhood epilepsy with centrotemporal spikes. In patients with childhood absence epilepsy, age at onset of seizures, coexisting seizure types, and photoconvulsive response in EEG were important risk factors for response to initial treatment

Metoklopramide bağlı akut distonik reaksiyon : İki olgu sunumu

Metoclopramide is a widely used antiemetic agent in paediatric population with the primary side-effect of extrapyramidal reactions. Incidence is 0.5-1% in children while incidence in young adults and elders is 25%. Patients can be misdiagnosed as meningitis, encephalitis, hypocalcemia, seizure and tetanus. We report two cases, 8-month-and 10-year-old boys referred to our hospital with a presumptive diagnosis of encephalitis and diagnosed as metoclopramide induced acute dystonic reaction, to stress this side-effect of metoclopramide.Metoklopramid, çocukluk çağında yaygın olarak kullanılan antiemetik bir ajan olup, en sık görülen yan etkisi ekstrapiramidal reaksiyonlardır. Çocuklarda insidansı % 0.5-1 iken, adölesan ve yaşlılarda % 25 civarındadır. Hastalar, meninjit, ensefalit, hipokalsemi, nöbet ve tetanoz şeklinde yanlış tanı alabilmektedir. Biz de ensefalit ön tanısı ile hastanemize sevk edilen 8 aylık ve 10 yaşında iki erkek hastada, metoklopramide bağlı akut distonik reaksiyon gelişen iki vaka saptadık

HASHIMOTO'S ENCEPHALOPATHY: AN UNUSUAL CAUSE OF SEIZURES

WOS: 000307988400023Hashimoto's encephalopathy is a rare, chronic relapsing and remitting encephalopathy associated with auto-antibodies against thyroid components. Clinically it is characterized by tremor, myoclonus, stroke-like episodes, seizures, impairment of consciousness, and dementia. We described here a 13-year-old boy who presented with generalized tonic clonic seizures associated with Hashimoto's encephalopathy. After corticosteroid treatment, his neurological features improved dramatically. As a result, Hashimoto's encephalopathy should be considered in cases of unexplained encephalopathy and seizures in pediatric patients

Immune thrombocytopenic purpura after recombinant hepatitis B vaccine: Case report

WOS: 000254582800025Recombinant hepatitis B vaccine, which is used throughout the world, rarely has systemic adverse events like polyradiculoneuritis, demyelination of central nervous system. otoimmune hemolytic anemia and immune thrombocytopenia, as well as local side effects. We diagnosed thrombocytopenic purpura in a 10 months-old case, which developed 3 weeks after the 3(rd) dose of the recombinant hepatitis B vaccine. There was no drug history or prior infection. Clinical and laboratory findings of autoimmune or malignant disorders were negative and the bone marrow aspirate was normal. We presented this case to emphasize that thrombocytopenia may develop after recombinant hepatitis B vaccine and thus Should be taken into consideration

Immune thrombocytopenic purpura after varicella infection: Case report

İmmün trombositopenik purpura çocukluk çağında en sık görülen kanama bozukluklarından birisi olup, patogenezinde trombositlere karşı antikorların gelişmesi rol oynamaktadır. İmmün trombositopenik purpura, idiopatik olabildiği gibi, enfeksiyon gibi altta yatan patolojiye bağlı olarak da meydana gelebilmektedir. Biz de varisella enfeksiyonu sonrasında gelişen bir immün trombositopenik purpura olgusunu bildirdik.Immun trombocytopenic purpura is the most common hemorrhagic disorder of the childhood and produced antibodies against platelets have major role in pathogenesis. Immun trombocytopenic purpura may be seen without any reason or secondary to underlying pathologies as infections. Here we present a case of immun thrombocytopenic purpura secondary to varicella infection

Immune thrombocytopenic purpura after varicella infection: Case report

İmmün trombositopenik purpura çocukluk çağında en sık görülen kanama bozukluklarından birisi olup, patogenezinde trombositlere karşı antikorların gelişmesi rol oynamaktadır. İmmün trombositopenik purpura, idiopatik olabildiği gibi, enfeksiyon gibi altta yatan patolojiye bağlı olarak da meydana gelebilmektedir. Biz de varisella enfeksiyonu sonrasında gelişen bir immün trombositopenik purpura olgusunu bildirdik.Immun trombocytopenic purpura is the most common hemorrhagic disorder of the childhood and produced antibodies against platelets have major role in pathogenesis. Immun trombocytopenic purpura may be seen without any reason or secondary to underlying pathologies as infections. Here we present a case of immun thrombocytopenic purpura secondary to varicella infection