86 research outputs found
Assessment of resistance and non-resistance fractions of heavy metals concentration (Fe, Mn, Cr, Ni) in surface sediments from the southern of Caspian Sea of two stations (Tonekabon and Amirabad)
This study was conducted to determine some heavy metals (Fe, Mg, Cr, Ni) of surface sediment in the southern Caspian Sea during two seasons (Summer and Winter) in 2014-2015. 36 surface sediments samples (with triplicate) were collected at two stations (Tonekabon and Bandar Amirabad). All samples were analyzed using sequential extraction to indicate natural and anthropogenic sources. The results indicated that the percentage of non-resistance fraction in Tonekabon area were measured 3.5,45.0, 22.1 and 6.0 for Fe, Mg, Cr, Ni, respectively and in Amirabad area were 23.0,2.6,1.8 and 4.0, respectively. On the other hand, the percentage of resistance fraction values were obtained 96.5, 55.0, 77.9 and 94.0 in Tonekabon, and 77.0, 97.4, 98.2, and 96.0 in Amirabad region. The chemical speciation of Fe, Mg, Cr, Ni in most sampling stations were in the order of residual> oxidisableorganic > acid-reducible >exchangeable. The order of total concentration, non-resistance and resistance fraction were observed Fe>Mn>Ni>Cr, Mn>Fe>Ni>Cr and Fe>Mn>Ni>Cr, respectively. As a conclusion, results of total concentration, resistnace and non-resistance of Fe, Mn, Ni and Cr were lower than standard and earth shell (Igeo) in this area. This is shown that surface sediments of this area were not polluted with these heavy metals and bio available fraction provides little indication of potential interactions with the biotic components present in this environment
Molecular mechanisms and cellular functions of cGAS-STING signalling
The cGASâSTING signalling axis, comprising the synthase for the second messenger cyclic GMPâAMP (cGAS) and the cyclic GMPâAMP receptor stimulator of interferon genes (STING), detects pathogenic DNA to trigger an innate immune reaction involving a strong type I interferon response against microbial infections. Notably however, besides sensing microbial DNA, the DNA sensor cGAS can also be activated by endogenous DNA, including extranuclear chromatin resulting from genotoxic stress and DNA released from mitochondria, placing cGASâSTING as an important axis in autoimmunity, sterile inflammatory responses and cellular senescence. Initial models assumed that co-localization of cGAS and DNA in the cytosol defines the specificity of the pathway for non-self, but recent work revealed that cGAS is also present in the nucleus and at the plasma membrane, and such subcellular compartmentalization was linked to signalling specificity of cGAS. Further confounding the simple view of cGASâSTING signalling as a response mechanism to infectious agents, both cGAS and STING were shown to have additional functions, independent of interferon response. These involve non-catalytic roles of cGAS in regulating DNA repair and signalling via STING to NF-ÎșB and MAPK as well as STING-mediated induction of autophagy and lysosome- dependent cell death. We have also learnt that cGAS dimers can multimerize and undergo liquidâliquid phase separation to form biomolecular condensates that could importantly regulate cGAS activation. Here, we review the molecular mechanisms and cellular functions underlying cGASâSTING activation and signalling, particularly highlighting the newly emerging diversity of this signalling pathway and discussing how the specificity towards normal, damage-induced and infection-associated DNA could be achieved
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Properties of ferromagnetic ga1-xmnxp thin films synthesized by ion implantation and pulsed-laser melting
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Mn L3,2 X-ray absorption and magnetic circular dichroism in ferromagnetic Ga1-xMnxP
We have measured the X-ray absorption and X-ray magnetic circular dichroism (XMCD) at the Mn L{sub 3,2} edges in ferromagnetic Ga{sub 1-x}Mn{sub x}P for 0.018 {le} x {le} 0.042. Large XMCD asymmetries at the L{sub 3} edge indicate significant spin-polarization of the density of states at the Fermi energy. The temperature dependence of the XMCD and moment per Mn of 2.67 {+-} 0.45 {mu}{sub B} calculated using sum rules are consistent with magnetometry values. The spectral shapes of the X-ray absorption and XMCD are nearly identical with those for Ga{sub 1-x}Mn{sub x}As indicating that the hybridization of Mn d and anion p states is similar in the two materials
MnL3,2 x-ray absorption and magnetic circular dichroism in ferromagnetic Ga1âxMnxP
We have measured the X-ray absorption (XAS) and X-ray magnetic circular
dichroism (XMCD)at the Mn L3,2 edges in ferromagnetic Ga1-xMnxP for
0.018<x<0.042. Large XMCD asymmetries at the L3 edge indicate significant
spin-polarization of the density of states at the Fermi energy. The temperature
dependence of the XMCD and moment per Mn of 2.67 Bohr magnetons calculated
using sum rules are consistent with magnetometry values. The spectral shapes of
the XAS and XMCD are nearly identical with those for Ga1-xMnxAs indicating that
the hybridization of Mn d and anion p states is similar in the two materials
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