461 research outputs found
Scaling in high-temperature superconductors
A Hartree approximation is used to study the interplay of two kinds of
scaling which arise in high-temperature superconductors, namely critical-point
scaling and that due to the confinement of electron pairs to their lowest
Landau level in the presence of an applied magnetic field. In the neighbourhood
of the zero-field critical point, thermodynamic functions scale with the
scaling variable , which differs from the variable
suggested by the gaussian approximation.
Lowest-Landau-level (LLL) scaling occurs in a region of high field surrounding
the upper critical field line but not in the vicinity of the zero-field
transition. For YBaCuO in particular, a field of at least 10 T is needed to
observe LLL scaling. These results are consistent with a range of recent
experimental measurements of the magnetization, transport properties and,
especially, the specific heat of high- materials.Comment: 22 pages + 1 figure appended as postscript fil
Fluctuation Study of the Specific Heat of MgB2
The specific heat of polycrystalline MgB has been measured with
high resolution ac calorimetry from 5 to 45 K at constant magnetic fields. The
excess specific heat above T is discussed in terms of Gaussian
fluctuations and suggests that MgB is a bulk superconductor with
Ginzburg-Landau coherence length \AA . The transition-width
broadening in field is treated in terms of lowest-Landau-level (LLL)
fluctuations. That analysis requires that \AA . The underestimate
of the coherence length in field, along with deviations from 3D LLL
predictions, suggest that there is an influence from the anisotropy of B
between the c-axis and the a-b plane.Comment: Phys. Rev. B 66, 134515 (2002
Flux Lattice Melting and Lowest Landau Level Fluctuations
We discuss the influence of lowest Landau level (LLL) fluctuations near
H_{c2}(T) on flux lattice melting in YBaCuO (YBCO). We
show that the specific heat step of the flux lattice melting transition in YBCO
single crystals can be attributed largely to the degrees of freedom associated
with LLL fluctuations. These degrees of freedom have already been shown to
account for most of the latent heat. We also show that these results are a
consequence of the correspondence between flux lattice melting and the onset of
LLL fluctuations.Comment: 4 pages, 2 embedded figure
Numerical studies of the phase diagram of layered type II superconductors in a magnetic field
We report on simulations of layered superconductors using the
Lawrence-Doniach model in the framework of the lowest Landau level
approximation. We find a first order phase transition with a dependence
which agrees very well with the experimental ``melting'' line in YBaCuO. The
transition is not associated with vortex lattice melting, but separates two
vortex liquid states characterised by different degrees of short-range
crystalline order and different length scales of correlations between vortices
in different layers. The transition line ends at a critical end-point at low
fields. We find the magnetization discontinuity and the location of the lower
critical magnetic field to be in good agreement with experiments in YBaCuO.
Length scales of order parameter correlations parallel and perpendicular to the
magnetic field increase exponentially as 1/T at low temperatures. The dominant
relaxation time scales grow roughly exponentially with these correlation
lengths. We find that the first order phase transition persists in the presence
of weak random point disorder but can be suppressed entirely by strong
disorder. No vortex glass or Bragg glass state is found in the presence of
disorder. The consistency of our numerical results with various experimental
features in YBaCuO, including the dependence on anisotropy, and the temperature
dependence of the structure factor at the Bragg peaks in neutron scattering
experiments is demonstrated.Comment: 25 pages (revtex), 19 figures included, submitted to PR
Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway surface liquid.
Hyperglycaemia as a result of diabetes mellitus or acute illness is associated with increased susceptibility to respiratory infection with Staphylococcus aureus. Hyperglycaemia increases the concentration of glucose in airway surface liquid (ASL) and promotes the growth of S. aureus in vitro and in vivo. Whether elevation of other sugars in the blood, such as fructose, also results in increased concentrations in ASL is unknown and whether sugars in ASL are directly utilised by S. aureus for growth has not been investigated. We obtained mutant S. aureus JE2 strains with transposon disrupted sugar transport genes. NE768(fruA) exhibited restricted growth in 10 mM fructose. In H441 airway epithelial-bacterial co-culture, elevation of basolateral sugar concentration (5-20 mM) increased the apical growth of JE2. However, sugar-induced growth of NE768(fruA) was significantly less when basolateral fructose rather than glucose was elevated. This is the first experimental evidence to show that S. aureus directly utilises sugars present in the ASL for growth. Interestingly, JE2 growth was promoted less by glucose than fructose. Net transepithelial flux of D-glucose was lower than D-fructose. However, uptake of D-glucose was higher than D-fructose across both apical and basolateral membranes consistent with the presence of GLUT1/10 in the airway epithelium. Therefore, we propose that the preferential uptake of glucose (compared to fructose) limits its accumulation in ASL. Pre-treatment with metformin increased transepithelial resistance and reduced the sugar-dependent growth of S. aureus. Thus, epithelial paracellular permeability and glucose transport mechanisms are vital to maintain low glucose concentration in ASL and limit bacterial nutrient sources as a defence against infection
Stillbirth is associated with perceived alterations in fetal activity - findings from an international case control study
Background Stillbirth after 28 weeks gestation affects between 1.3–8.8 per 1000 births in high-income countries. The majority of stillbirths in this setting occur in women without established risk factors. Identification of risk factors which could be identified and managed in pregnancy is a priority in stillbirth prevention research. This study aimed to evaluate women’s experiences of fetal movements and how these relate to stillbirth. Methods An international internet-based case–control study of women who had a stillbirth ≥28 weeks’ gestation within 30 days prior to completing the survey (n = 153) and women with an ongoing pregnancy or a live born child (n = 480). The online questionnaire was developed with parent stakeholder organizations using a mixture of categorical and open–ended responses and Likert scales. Univariate and multiple logistic regression was used to determine crude (unadjusted) and adjusted odds ratios (aOR) with 95% confidence intervals (CI). Summative content analysis was used to analyse free text responses. Results Women whose pregnancy ended in stillbirth were less likely to check fetal movements (aOR 0.54, 95% CI 0.35–0.83) and were less likely to be told to do so by a health professional (aOR 0.55, 95% CI 0.36–0.86). Pregnancies ending in stillbirth were more frequently associated with significant abnormalities in fetal movements in the preceding two weeks; this included a significant reduction in fetal activity (aOR 14.1, 95% CI 7.27–27.45) or sudden single episode of excessive fetal activity (aOR 4.30, 95% CI 2.25–8.24). Cases described their perception of changes in fetal activity differently to healthy controls e.g. vigorous activity was described as “frantic”, “wild” or “crazy” compared to “powerful” or “strong”. Conclusions Alterations in fetal activity are associated with increased risk of stillbirth. Pregnant women should be educated about awareness of fetal activity and reporting abnormal activity to health professionals
Evolutionary Mechanisms of Long-Term Genome Diversification Associated With Niche Partitioning in Marine Picocyanobacteria.
Marine picocyanobacteria of the genera Prochlorococcus and Synechococcus are the most abundant photosynthetic organisms on Earth, an ecological success thought to be linked to the differential partitioning of distinct ecotypes into specific ecological niches. However, the underlying processes that governed the diversification of these microorganisms and the appearance of niche-related phenotypic traits are just starting to be elucidated. Here, by comparing 81 genomes, including 34 new Synechococcus, we explored the evolutionary processes that shaped the genomic diversity of picocyanobacteria. Time-calibration of a core-protein tree showed that gene gain/loss occurred at an unexpectedly low rate between the different lineages, with for instance 5.6 genes gained per million years (My) for the major Synechococcus lineage (sub-cluster 5.1), among which only 0.71/My have been fixed in the long term. Gene content comparisons revealed a number of candidates involved in nutrient adaptation, a large proportion of which are located in genomic islands shared between either closely or more distantly related strains, as identified using an original network construction approach. Interestingly, strains representative of the different ecotypes co-occurring in phosphorus-depleted waters (Synechococcus clades III, WPC1, and sub-cluster 5.3) were shown to display different adaptation strategies to this limitation. In contrast, we found few genes potentially involved in adaptation to temperature when comparing cold and warm thermotypes. Indeed, comparison of core protein sequences highlighted variants specific to cold thermotypes, notably involved in carotenoid biosynthesis and the oxidative stress response, revealing that long-term adaptation to thermal niches relies on amino acid substitutions rather than on gene content variation. Altogether, this study not only deciphers the respective roles of gene gains/losses and sequence variation but also uncovers numerous gene candidates likely involved in niche partitioning of two key members of the marine phytoplankton
TFOS European Ambassador meeting: Unmet needs and future scientific and clinical solutions for ocular surface diseases
The mission of the Tear Film & Ocular Surface Society (TFOS) is to advance the research, literacy, and educational aspects of the scientific field of the tear film and ocular surface. Fundamental to fulfilling this mission is the TFOS Global Ambassador program. TFOS Ambassadors are dynamic and proactive experts, who help promote TFOS initiatives, such as presenting the conclusions and recommendations of the recent TFOS DEWS II™, throughout the world. They also identify unmet needs, and propose future clinical and scientific solutions, for management of ocular surface diseases in their countries. This meeting report addresses such needs and solutions for 25 European countries, as detailed in the TFOS European Ambassador meeting in Rome, Italy, in September 2019
- …