Influence of a Hypotensive Agent Upon Coronary Blood Flow and Cardiac Metabolism

There has been considerable doubt as to the direct relationship of coronary blood flow and the level of arterial or perfusing pressure forcing blood into the vessels of the heart muscle. Attempts to delineate clearly these relationships have been complicated by concomitant effects induced by circulating epinephrine. The drug dibenzyline2 makes it possible to evaluate the influence of hypotension on coronary blood flow. Dibenzyline injection induces a fall in blood pressure while maintaining essentially unchanged the cardiac output and the cerebral blood flow (1)