11 research outputs found
A novel supramolecular catalytic system bazed on amphiphilic triphenylphosphonium bromide for the hydrolysis of phosphorus acid esters
The biomimetic nature of micellar catalysis can significantly affect the rate of chemical reactions due to the effects of concentration and the change of microenvironment. A novel supramolecular catalytic system bazed on amphiphilic triphenylphosphonium bromide for the hydrolysis of phosphorus acid ester
Diabetes mellitus type 2 in adults
Public organization “Russian Association of Endocrinologists”. Clinical guidelines. 
Diabetes mellitus type 1 in adults
Public organization “Russian Association of Endocrinologists”. Clinical guidlines
Ekskretsiya fosfolipidov s mochoy u bol'nykh diabeticheskoy nefropatiey
Π¦Π΅Π»Ρ. ΠΠ·ΡΡΠΈΡΡ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°Ρ
Π°ΡΠ½ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ (Π‘Π) 1 ΡΠΈΠΏΠ° ΡΠΊΡΠΊΡΠ΅ΡΠΈΡ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΈΠ΄ΠΎΠ² Ρ ΠΌΠΎΡΠΎΠΉ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° Π³Π»ΠΈΠΊΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ, ΡΡΠ°Π΄ΠΈΠΈ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π΅ΡΡΠΎΠΏΠ°ΡΠΈΠΈ ΠΈ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 113 Π±ΠΎΠ»ΡΠ½ΡΡ
Π‘Π 1 ΡΠΈΠΏΠ° (75 ΠΆΠ΅Π½ΡΠΈΠ½ ΠΈ 38 ΠΌΡΠΆΡΠΈΠ½) Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 18 Π΄ΠΎ 68 Π»Π΅Ρ (ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ ? 37,23 ? 1.21), Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π²Π°ΡΡΠΈΡΠΎΠ²Π°Π»Π° ΠΎΡ 1 ΠΌΠ΅Ρ Π΄ΠΎ 35 Π»Π΅Ρ (Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ 13,59 + 0,8 Π»Π΅Ρ). ΠΠ°ΡΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠΎΡΠ΅ΠΊ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈΡΡ ΠΏΠΎ Π²Π΅Π»ΠΈΡΠΈΠ½Π΅ ΠΊΠ»ΡΠ±ΠΎΡΠΊΠΎΠ²ΠΎΠΉ ΡΠΈΠ»ΡΡΡΠ°ΡΠΈΠΈ. ΠΡΠ΅Π½ΠΊΠ° ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΡΠΈΡΠΎΠΌΠ΅ΠΌΠ±ΡΠ°Π½ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΠΏΠΎ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΈΠ΄ΠΎΠ² ΡΡΡΠΎΡΠ½ΠΎΠΉ ΠΌΠΎΡΠΈ. Π ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ Π³ΡΡΠΏΠΏΡ Π²ΠΎΡΠ»ΠΈ 24 Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΠΈΡΠ°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΊΡΠΊΡΠ΅ΡΠΈΠΈ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΈΠ΄ΠΎΠ² Ρ ΠΌΠΎΡΠΎΠΉ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Π‘Π 1 ΡΠΈΠΏΠ° ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎ Π·Π΄ΠΎΡΠΎΠ²ΡΠΌΠΈ. ΠΠΊΡΠΊΡΠ΅ΡΠΈΡ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΈΠ΄ΠΎΠ² Ρ ΠΌΠΎΡΠΎΠΉ ΠΏΠΎΠ²ΡΡΠ°Π΅ΡΡΡ Ρ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΌΠΈΠΊΡΠΎΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π² ΠΏΠΎΡΠΊΠ°Ρ
. Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΌΠΈΠΊΡΠΎΠ°Π»ΡΠ±ΡΠΌΠΈΠ½ΡΡΠΈΠ΅ΠΉ ΡΠΊΡΠΊΡΠ΅ΡΠΈΡ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΈΠ΄ΠΎΠ² Ρ ΠΌΠΎΡΠΎΠΉ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 1,03?0,4 ΠΌΠΌΠΎΠ»Ρ/Π» ΠΈ Π·Π°Π²ΠΈΡΠ΅Π»Π° ΠΎΡ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠΈ ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°. ΠΡΠ²ΠΎΠ΄Ρ. Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
Π‘Π ΠΏΠΎΠ²ΡΡΠ΅Π½Π° ΡΠΊΡΠΊΡΠ΅ΡΠΈΡ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΈΠ΄ΠΎΠ² Ρ ΠΌΠΎΡΠΎΠΉ Π² ΡΠΎΡΡΠΎΡΠ½ΠΈΠΈ Π΄Π΅ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠΈ ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°, Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΠΎ ΠΎΡ Π΄Π°Π²Π½ΠΎΡΡΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠΎΡΠ΅ΠΊ. ΠΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΡ ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΈΠ΄ΡΡΠΈΠΈ ΡΠΎΠ»ΡΠΊΠΎ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π½ΠΎΡΠΌΠΎΠ°Π»ΡΠ±ΡΠΌΠΈΠ½ΡΡΠΈΠ΅ΠΉ Ρ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ Π‘Π ΠΌΠ΅Π½Π΅Π΅ 5 Π»Π΅Ρ. ΠΡΠΈ Π΄Π°Π²Π½ΠΎΡΡΠΈ Π΄ΠΈΠ°Π±Π΅ΡΠ° ΠΎΡ 5 Π΄ΠΎ 15 Π»Π΅Ρ ΡΠΊΡΠΊΡΠ΅ΡΠΈΡ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΈΠ΄ΠΎΠ² Π½Π°ΡΠ°ΡΡΠ°Π΅Ρ ΠΏΠΎ ΠΌΠ΅ΡΠ΅ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π΅ΡΡΠΎΠΏΠ°ΡΠΈΠΈ ΠΈ Π½Π΅ ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ ΠΏΡΠΈ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠΈ ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°. ΠΡΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΈ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠΎΡΠ΅ΠΊ ΡΠΊΡΠΊΡΠ΅ΡΠΈΡ ΡΠΎΡΡΠΎΠ»ΠΈΠΏΠΈΠ΄ΠΎΠ² Ρ ΠΌΠΎΡΠΎΠΉ ΡΠΏΠΎΠ½ΡΠ°Π½Π½ΠΎ ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ, Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΠΎ ΠΎΡ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠΈ Π΄ΠΈΠ°Π±Π΅ΡΠ°
Physicochemical properties and esterolytic reactivity of oxime functionalized surfactants in pH-responsive mixed micellar system
A novel supramolecular catalytic system bazed on amphiphilic triphenylphosphonium bromide for the hydrolysis of phosphorus acid esters
The biomimetic nature of micellar catalysis can significantly affect the rate of chemical reactions due to the effects of concentration and the change of microenvironment. A novel supramolecular catalytic system bazed on amphiphilic triphenylphosphonium bromide for the hydrolysis of phosphorus acid ester
Nanosized Reactors Based on Polyethyleneimines:Β From Microheterogeneous Systems to Immobilized Catalysts
Therapy of Organophosphate Poisoning via Intranasal Administration of 2-PAM-Loaded Chitosomes
Chitosan-decorated liposomes were proposed for the first time for the intranasal delivery of acetylcholinesterase (AChE) reactivator pralidoxime chloride (2-PAM) to the brain as a therapy for organophosphorus compounds (OPs) poisoning. Firstly, the chitosome composition based on phospholipids, cholesterol, chitosans (Cs) of different molecular weights, and its arginine derivative was developed and optimized. The use of the polymer modification led to an increase in the encapsulation efficiency toward rhodamine B (RhB; ~85%) and 2-PAM (~60%) by 20% compared to conventional liposomes. The formation of monodispersed and stable nanosized particles with a hydrodynamic diameter of up to 130 nm was shown using dynamic light scattering. The addition of the polymers recharged the liposome surface (from −15 mV to +20 mV), which demonstrates the successful deposition of Cs on the vesicles. In vitro spectrophotometric analysis showed a slow release of substrates (RhB and 2-PAM) from the nanocontainers, while the concentration and Cs type did not significantly affect the chitosome permeability. Flow cytometry and fluorescence microscopy qualitatively and quantitatively demonstrated the penetration of the developed chitosomes into normal Chang liver and M-HeLa cervical cancer cells. At the final stage, the ability of the formulated 2-PAM to reactivate brain AChE was assessed in a model of paraoxon-induced poisoning in an in vivo test. Intranasal administration of 2-PAM-containing chitosomes allows it to reach the degree of enzyme reactivation up to 35 ± 4%