Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenetic alopecia and measuring the patients\u27 satisfactory rate

Objective: According to the hypothesis regarding the stimulating effect of adenosine on increasing fibroblast growth factor-7 in dermal papilla cells and its vasorelaxant effect, we performed this study to compare the effect of topical minoxidil 5% and adenosine 0.75% on male pattern androgenic alopecia. Methods and materials: This prospective-randomized study recruited 110 male patients, who suffered from grade II-V Hamilton androgenic alopecia. Fifty-five patients received minoxidil 5% (group-1) and others received adenosine 0.75% (group-2). Later, 16 patients excluded due to allergic reactions or loss to follow-up. After 3 and 6 months of treatment, complete and relative recovery rates alongside patients\u27 satisfactory rate (faster prevention of primary hair loss and appearance of newly grown hair) were compared between groups. Results: After 3 months of treatment, relative recovery was achieved in 2.4% and 1.9% of patients in group-1 and group-2, which was not significantly different (p-value= 0.17). During 6 months, relative recovery rate did not change nighter within nor between the groups (p-value =0.99) and after 6 months none of the patients achieved complete recovery. However, the patients\u27 satisfactory rate was significantly higher in the group-2 (p-value =0.003). Conclusion: In light of the results, adenosine has no statistically superiority to minoxidil on treatment of androgenic alopecia according to the recovery rates. However, the patients were significantly more satisfied with the adenosine because of the faster prevention of hair loss and appearance of the newly grown hairs. It seems further studies with larger sample size or different drug dosages are required to clarify the findings. </span

A Comparative Study Of The Predisposing Factors And Natural History Of Lichen sclerosus ET Atrophicus (LSA) In Children And Adults

Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory dermatosis that results in white plaques with epidermal atrophy usually affecting the genital area in both adults and children. The causes of LSA are not clear but possible predisponsing factors include trauma, infection (borrelia, human papilloma virus), autoimmune diseases and local irritation. This study is a retrospective case review of children and adults with LSA attending the department of Dermatology at the Royal Infirmary in Edinburgh, clinical notes for 22 patients were reviewed for age, sex, personal and familial history, symptoms associated diseases and clinical course and treatment. The mean ages at diagnosis of LSA in 9 children (8F: 1M) and 13 adults (13 F) were 7 and 57.5 years respectively. The mean duration of illness was 1.5 year in children and 5.5 year in adults. Itching was the most common symptom in both children and adults. Children also suffered with difficulties in defaecation and in micturation , dribbling, incontinence, constipation and bleeding. Atopy and hypothyroidism were common associated conditions in both the groups. Squamous cell carcinoma of the vulva was confirmed in two adult patients. This study showed the variable symptoms in children, which seemed more severe than in the adult population

Pityriasis rubra pilaris following exposure to dolomite

In this case report, we present a 30-year-old man who developed pityriasis rubra pilaris (PRP) following exposure to Dolomite. The diagnosis of PRP was confirmed histologically and the patient was successfully treated with acitretin and cyclosporine

Topical Sucralfate Versus Hydrocortisone Cream In The Management Of Diaper Dermatitis : A Randomized, Doubleblind Clinical Trial

Topical corticosteroids are currently used for treatment of diaper dermatitis. Previous studies have shown the efficacy of sucralfate in the treatment of diaper dermatitis and contact dermatitis in peri-stomal areas. To evaluate the efficacy of topical sucralfate in comparison with hydrocortisone cream in the treatment of diaper dermatitis, the present study was under taken. In a double &#x00E2;&#x20AC;&quot;blind randomized clinical trial, 64 patients with diaper dermatitis were treated with sucralfate cream 4&#x0025; or hydrocortisone cream randomly. The duration of the treatment wad 8 weeks and the patients were evaluated every two weeks until complete healing. The results were evaluated by chi-square test. Complete healing (more than 50&#x0025; improvement) occurred in 90.6&#x0025; and partial healing (20-25&#x0025; improvement) in rest of the patients in each group (p&gt;0.05). Topical sucralfate is an effective, cheap therapeutic intervention for diaper dermatitis. Which has equal efficacy with topical hydrocortisone cream

Comparison between the efficacy of 10% zinc sulfate solution with 4% hydroquinone cream on improvement of melasma

Background: Melasma, a common disorder of hyperpigmentation, is often difficult to treat. Although 10% zinc sulfate solution has been reported to be useful for patients with melasma, controlled trials are lacking. Materials and Methods: 72 women with moderate to severe melasma were divided randomly into 2 groups. Group A were treated with 10% zinc sulfate solution and group B with 4% hydroquinone cream twice-daily. The results were evaluated by photoevaluation by patients based on subjective satisfaction and a blinded dermatologist using MASI score. Assessments were obtained at baseline and at 2 and 6 months after starting treatment. Results: According to MASI score changes during treatment, there was a reduction in both groups at 2 months, however, the reduction in group B was more significant (the reduction in mean ± SD MASI was 0.7 ± 0.7 in group A vs. 2.7 ± 1.6 in group B). In addition, the patients in group B continued to decrease MASI score for the remainder of the study period at 6 months follow-up (0.3 ± 0.5) in comparison with patients in group A who did not show more reduction in MASI score. Conclusions: The study indicates that topical zinc sulfate is not as effective in treating disease as was observed in the previous open study. A comparative study with sunscreen and placebo is necessary to determine if topical zinc sulfate is truly superior to sunscreen and placebo in this respect