Integrin‐Targeted, Short Interfering RNA Nanocomplexes for Neuroblastoma Tumor‐Specific Delivery Achieve MYCN Silencing with Improved Survival

The authors aim to develop siRNA therapeutics for cancer that can be administered systemically to target tumors and retard their growth. The efficacy of systemic delivery of siRNA to tumors with nanoparticles based on lipids or polymers is often compromised by their rapid clearance from the circulation by the liver. Here, multifunctional cationic and anionic siRNA nanoparticle formulations are described, termed receptor‐targeted nanocomplexes (RTNs), that comprise peptides for siRNA packaging into nanoparticles and receptor‐mediated cell uptake, together with lipids that confer nanoparticles with stealth properties to enhance stability in the circulation, and fusogenic properties to enhance endosomal release within the cell. Intravenous administration of RTNs in mice leads to predominant accumulation in xenograft tumors, with very little detected in the liver, lung, or spleen. Although non‐targeted RTNs also enter the tumor, cell uptake appears to be RGD peptide‐dependent indicating integrin‐mediated uptake. RTNs with siRNA against MYCN (a member of the Myc family of transcription factors) in mice with MYCN‐amplified neuroblastoma tumors show significant retardation of xenograft tumor growth and enhanced survival. This study shows that RTN formulations can achieve specific tumor‐targeting, with minimal clearance by the liver and so enable delivery of tumor‐targeted siRNA therapeutics

Intelligent Transportation Systems in Smart City: A Systematic Survey

The idea of Smart Cities (SCs) was developed to digitize conventional urban living areas and redevelop using digital equipment to enhance lifestyle and resident security. Smart cities cover a wide range of applications such as smart government, smart energy, smart transportation, smart health, and smart education. In this paper, we have examined the mobility-related application e.g., smart transportation. We have focused on related to smart transportation like traffic safety, passenger and driver safety, obstacle detection, accident prevention, crime prevention, and detection, and more importantly smart vehicles like UAVs which played a key role in making these gadgets easy to use in urban environments. For a brief overview, 63 academic publications are examined in the field of ITS and SC technologies. Furthermore, we have provided possible solutions in terms of security in the smart transportation system