Neutralization, effector function and immune imprinting of Omicron variants

Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots in the receptor-binding domain$^{1}$ (RBD) of the spike protein. The effects of these mutations on viral infection and transmission and the efficacy of vaccines and therapies remains poorly understood. Here we demonstrate that recently emerged BQ.1.1 and XBB.1.5 variants bind host ACE2 with high affinity and promote membrane fusion more efficiently than earlier Omicron variants. Structures of the BQ.1.1, XBB.1 and BN.1 RBDs bound to the fragment antigen-binding region of the S309 antibody (the parent antibody for sotrovimab) and human ACE2 explain the preservation of antibody binding through conformational selection, altered ACE2 recognition and immune evasion. We show that sotrovimab binds avidly to all Omicron variants, promotes Fc-dependent effector functions and protects mice challenged with BQ.1.1 and hamsters challenged with XBB.1.5. Vaccine-elicited human plasma antibodies cross-react with and trigger effector functions against current Omicron variants, despite a reduced neutralizing activity, suggesting a mechanism of protection against disease, exemplified by S309. Cross-reactive RBD-directed human memory B cells remained dominant even after two exposures to Omicron spikes, underscoring the role of persistent immune imprinting

Search for the decay B+→K‾∗0K∗+B^+\rightarrow\overline{K}{}^{*0}K^{*+} at Belle

We report a search for the rare charmless decay $B^+\rightarrow\overline{K}{}^{*0}K^{*+}$ using a data sample of $772\times10^6$ $B\bar{B}$ pairs collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. No statistically significant signal is found and a 90% confidence-level upper limit is set on the decay branching fraction as $\mathcal{B}(B^+\rightarrow\overline{K}{}^{*0}K^{*+}) <1.31\times 10^{-6}$.Comment: 8 pages, 3 figures, submitted to PRD(RC

Search for Bs0→γγB_{s}^{0}\rightarrow\gamma\gamma and a measurement of the branching fraction for Bs0→ϕγB_{s}^{0}\rightarrow\phi\gamma

We search for the decay $B_{s}^{0}\rightarrow\gamma\gamma$ and measure the branching fraction for $B_{s}^{0}\rightarrow\phi\gamma$ using 121.4~$\textrm{fb}^{-1}$ of data collected at the $\Upsilon(\mathrm{5}S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^{+}e^{-}$ collider. The $B_{s}^{0}\rightarrow\phi\gamma$ branching fraction is measured to be $(3.6 \pm 0.5 (\mathrm{stat.}) \pm 0.3 (\mathrm{syst.}) \pm 0.6 (f_{s})) \times 10^{-5}$, where $f_{s}$ is the fraction of $B_{s}^{(*)}\bar{B}_{s}^{(*)}$ in $b\bar{b}$ events. Our result is in good agreement with the theoretical predictions as well as with a recent measurement from LHCb. We observe no statistically significant signal for the decay $B_{s}^{0}\rightarrow\gamma\gamma$ and set a $90\%$ confidence-level upper limit on its branching fraction at $3.1 \times 10^{-6}$. This constitutes a significant improvement over the previous result.Comment: 6 pages, 3 figure

Measurement of e+e−→γχcJe^+e^- \to \gamma\chi_{cJ} via initial state radiation at Belle

The process $e^+e^- \to \gamma\chi_{cJ}$ ($J$=1, 2) is studied via initial state radiation using 980 fb$^{-1}$ of data at and around the $\Upsilon(nS)$ ($n$=1, 2, 3, 4, 5) resonances collected with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. No significant signal is observed except from $\psi(2S)$ decays. Upper limits on the cross sections between $\sqrt{s}=3.80$ and $5.56~{\rm GeV}$ are determined at the 90% credibility level, which range from few pb to a few tens of pb. We also set upper limits on the decay rate of the vector charmonium [$\psi(4040$), $\psi(4160)$, and $\psi(4415)$] and charmoniumlike [$Y(4260)$, $Y(4360)$, and $Y(4660)$] states to $\gamma\chi_{cJ}$.Comment: Accepted by PR

Measurements of the masses and widths of the Σc(2455)0/++\Sigma_{c}(2455)^{0/++} and Σc(2520)0/++\Sigma_{c}(2520)^{0/++} baryons

We present measurements of the masses and decay widths of the baryonic states $\Sigma_{c}(2455)^{0/++}$ and $\Sigma_{c}(2520)^{0/++}$ using a data sample corresponding to an integrated luminosity of 711 fb$^{-1}$ collected with the Belle detector at the KEKB $e^{+}e^{-}$ asymmetric-energy collider operating at the $\Upsilon(4S)$ resonance. We report the mass differences with respect to the $\Lambda_{c}^{+}$ baryon $M(\Sigma_{c}(2455)^{0})-M(\Lambda_{c}^{+}) = 167.29\pm0.01\pm0.02$ MeV/$c^{2}$, $M(\Sigma_{c}(2455)^{++})-M(\Lambda_{c}^{+}) = 167.51\pm0.01\pm0.02$ MeV/$c^{2}$, $M(\Sigma_{c}(2520)^{0})-M(\Lambda_{c}^{+}) = 231.98\pm0.11\pm0.04$ MeV/$c^{2}$, $M(\Sigma_{c}(2520)^{++})-M(\Lambda_{c}^{+}) = 231.99\pm0.10\pm0.02$ MeV/$c^{2}$, and the decay widths $\Gamma(\Sigma_{c}(2455)^{0}) = 1.76\pm0.04^{+0.09}_{-0.21}$ MeV/$c^{2}$, $\Gamma(\Sigma_{c}(2455)^{++}) = 1.84\pm0.04^{+0.07}_{-0.20}$ MeV/$c^{2}$, $\Gamma(\Sigma_{c}(2520)^{0}) = 15.41\pm0.41^{+0.20}_{-0.32}$ MeV/$c^{2}$, $\Gamma(\Sigma_{c}(2520)^{++}) = 14.77\pm0.25^{+0.18}_{-0.30}$ MeV/$c^{2}$, where the first uncertainties are statistical and the second are systematic. The isospin mass splittings are measured to be $M(\Sigma_{c}(2455)^{++})-M(\Sigma_{c}(2455)^{0})=0.22\pm0.01\pm0.01$ MeV/$c^{2}$ and $M(\Sigma_{c}(2520)^{++})-M(\Sigma_{c}(2520)^{0})=0.01\pm0.15\pm0.03$ MeV/$c^{2}$. These results are the most precise to date.Comment: 13 pages, 4 figures, Submitted to PRD(RC

Evidence of Υ(1S)→J/ψ+χc1\Upsilon(1S) \to J/\psi+\chi_{c1} and search for double-charmonium production in Υ(1S)\Upsilon(1S) and Υ(2S)\Upsilon(2S) decays

Using data samples of $102\times10^6$ $\Upsilon(1S)$ and $158\times10^6$ $\Upsilon(2S)$ events collected with the Belle detector, a first experimental search has been made for double-charmonium production in the exclusive decays $\Upsilon(1S,2S)\rightarrow J/\psi(\psi')+X$, where $X=\eta_c$, $\chi_{cJ} (J=~0,~1,~2)$, $\eta_c(2S)$, $X(3940)$, and $X(4160)$. No significant signal is observed in the spectra of the mass recoiling against the reconstructed $J/\psi$ or $\psi'$ except for the evidence of $\chi_{c1}$ production with a significance of $4.6\sigma$ for $\Upsilon(1S)\rightarrow J/\psi+\chi_{c1}$. The measured branching fraction \BR(\Upsilon(1S)\rightarrow J/\psi+\chi_{c1}) is $(3.90\pm1.21(\rm stat.)\pm0.23 (\rm syst.))\times10^{-6}$. The $90\%$ confidence level upper limits on the branching fractions of the other modes having a significance of less than $3\sigma$ are determined. These results are consistent with theoretical calculations using the nonrelativistic QCD factorization approach.Comment: 12 pages, 4 figures, 1 table. The fit range was extended to include X(4160) signal according to referee's suggestions. Other results unchanged. Paper was accepted for publication as a regular article in Physical Review

Measurements of the Υ(10860)\Upsilon(10860) and Υ(11020)\Upsilon(11020) resonances via σ(e+e−→Υ(nS)π+π−)\sigma(e^+e^-\rightarrow\Upsilon(n{\rm S})\pi^+\pi^-)

We report new measurements of the total cross sections for $e^+e^-\to \Upsilon(n{\rm S})\pi^+\pi^-$ ($n$ = 1, 2, 3) and $e^+e^-\to b\bar b$ from a high-luminosity fine scan of the region $\sqrt{s} = 10.63$-$11.05$ GeV with the Belle detector. We observe that the $\Upsilon(n{\rm S})\pi^+\pi^-$ spectra have little or no non-resonant component and extract from them the masses and widths of $\Upsilon(10860)$ and $\Upsilon(11020)$ and their relative phase. We find $M_{10860}=(10891.1\pm3.2^{+0.6}_{-1.7})$ MeV/$c^2$ and \Gamma_{10860}=(53.7^{+7.1}_{-5.6}\,^{+1.3}_{-5.4}) MeV and report first measurements M_{11020}=(10987.5^{+6.4}_{-2.5}\,^{+9.0}_{-2.1}) MeV/$c^2$, \Gamma_{11020}=(61^{+9}_{-19}\,^{+2}_{-20}) MeV, and \phi_{\rm 11020}-\phi_{\rm 10860} = (-1.0\pm0.4\,^{+1.4}_{-0.1}) rad.Comment: University of Cincinnati preprint UCHEP-15-01, submitted to Physical Review D - Rapid Communication

Invariant-mass and fractional-energy dependence of inclusive production of di-hadrons in e+e−e^+e^- annihilation at s=\sqrt{s}= 10.58 GeV

The inclusive cross sections for di-hadrons of charged pions and kaons ($e^+e^- \rightarrow hhX$) in electron-positron annihilation are reported. They are obtained as a function of the total fractional energy and invariant mass for any di-hadron combination in the same hemisphere as defined by the thrust event-shape variable and its axis. Since same-hemisphere di-hadrons can be assumed to originate predominantly from the same initial parton, di-hadron fragmentation functions are probed. These di-hadron fragmentation functions are needed as an unpolarized baseline in order to quantitatively understand related spin-dependent measurements in other processes and to apply them to the extraction of quark transversity distribution functions in the nucleon. The di-hadron cross sections are obtained from a $655\,{\rm fb}^{-1}$ data sample collected at or near the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+ e^-$ collider.Comment: 21 pages, 18 figures plus 25 figures in supplemental material, submitted to PR

Observation of a new charged charmoniumlike state in B -> J/psi K pi decays

We present the results of an amplitude analysis of anti-B0 -> J/psi K- pi+ decays. A new charged charmoniumlike state Zc(4200)+ decaying to J/psi pi+ is observed with a significance of 6.2 sigma. The mass and width of the Zc(4200)+ are 4196 +31-29 +17-13 MeV/c^2 and 370 +70-70 +70-132 MeV, respectively; the preferred assignment of the quantum numbers is J^P = 1^+. In addition, we find evidence for Zc(4430)+ -> J/psi pi+. The analysis is based on a 711 fb^-1 data sample collected by the Belle detector at the asymmetric-energy e+ e- collider KEKB.Comment: 14 pages, 13 figure