Psychological wellbeing in chronic disease from a gender perspective: psychosocial variables and brief psychological interventions

La transición epidemiológica en occidente ha supuesto grandes cambios en los patrones de morbi-mortalidad, con un aumento exponencial de las enfermedades no transmisibles (ENT). Esto provocó un cambio en la concepción de salud hacia una perspectiva más integradora, en la que los factores biopsicosociales eran necesarios para explicar los procesos de salud-enfermedad y las personas por tanto se convertían en agentes activos, en responsables más que meros sujetos pasivos a la espera de recibir medicación. Las enfermedades cardiovasculares (ECV) son el conjunto de ENT más prevalente y con una mayor tasa de mortalidad a nivel mundial. Históricamente han sido consideradas enfermedades masculinas, aunque las estadísticas muestran una mayor mortalidad en mujeres. Esta brecha de sexo en las ECV parece venir determinada por un sesgo de género que afecta al diagnóstico e intervención y hace necesaria una perspectiva de género a la hora de abordarlas. Estas enfermedades son el claro ejemplo de la necesidad de entender la salud de manera integral, ya que los principales factores de riesgo cardiovascular son modificables y, por tanto, prevenibles. Uno de los objetivos de la Psicología de la Salud es precisamente conocer los factores subyacentes que influyen en el comportamiento saludable de este tipo de pacientes con el fin de promoverlo. En esta dirección, numerosas investigaciones han relacionado las conductas saludables con variables psicológicas como la autoeficacia, una regulación emocional adecuada o el bienestar psicológico, que se vinculan con un mayor compromiso terapéutico y cambios saludables en el estilo de vida. A su vez, las ECV se han encontrado relacionadas con unos niveles altos de ansiedad, estrés y depresión, y estas se relacionan asimismo con un peor pronóstico de la enfermedad y una peor calidad de vida en estos pacientes. Por esta relación entre factores psicológicos y determinantes de salud cardiovascular, se necesitan intervenciones dirigidas a intentar promover estas variables psicológicas con el objetivo de mejorar su ajuste a la enfermedad y la reducción del riesgo cardiovascular. En esta línea, y partiendo de los prometedores resultados de la telemedicina para promover conductas saludables, es necesario conocer si este tipo de intervenciones serían eficaces para mejorar las variables psicológicas antes mencionadas en pacientes con ECV. De igual modo, la brecha de salud entre mujeres y hombres hace necesaria la implementación de una perspectiva de género en la investigación e intervención sobre la misma. Por todo lo anterior, la presente Tesis Doctoral tiene como objetivo profundizar en el análisis de los factores psicosociales que afectan a la salud y que se relacionan con la ECV, así como poner a prueba la eficacia de intervenciones mHealth para promover las variables psicológicas que se relacionan con los comportamientos saludables y el bienestar psicológico de esta población. Se proponen, por tanto, una serie de investigaciones que se han materializado en la publicación de tres artículos científicos independientes e interrelacionados, los cuales se presentan a continuación. El primer estudio es una revisión sistemática que tiene como objetivo explorar los factores psicosociales que se han estudiado para explicar la vulnerabilidad diferencial del bienestar psicológico en mujeres y hombres. Partiendo de un modelo biopsicosocial, complementado con la perspectiva de género, se incluyeron estudios que evaluaban las diferencias de sexo y género en la ansiedad y su comorbilidad. Siguiendo la metodología PRISMA, se realizó una búsqueda sistemática en las bases de datos electrónicas PubMed y PsycInfo, incorporando estudios empíricos y revisiones publicadas entre 2008 - 2021. Tras la búsqueda, 44 estudios fueron incluidos, los cuales se analizaron y clasificaron en función del objeto de estudio. Finalmente, se realizó una síntesis narrativa cualitativa de los resultados. Los resultados de los estudios incluidos mostraron que las diferencias en la vulnerabilidad psicológica entre sexos se han analizado históricamente a partir de factores biológicos o factores de corte psicosocial; sin embargo, estudios que abordasen la problemática aludiendo de manera conjunta a ambos factores fueron escasos El segundo estudio tiene como objetivo evaluar la efectividad de una intervención psicológica mHealth en regulación emocional para mejorar el afecto positivo y la autoeficacia en personas con ECV. Para ello, se diseñó un ensayo controlado no aleatorizado de dos brazos, en el que la muestra de 69 pacientes cardiovasculares participó en un grupo experimental o un grupo control o de tratamiento habitual. La intervención, basada en el proceso de regulación emocional (Gross, 1998; Leahy, 2011), está conformada por dos fases. La primera consistió en una sesión presencial y la segunda en una intervención basada en mHealth de 14 días. Ambos grupos fueron evaluados en múltiples ocasiones en afecto positivo y autoeficacia (crónica y cardíaca), incluyendo dos follow-ups, lo que permitió un análisis de medidas repetidas. Los resultados indican que la intervención psicológica mHealth fue efectiva para mejorar el afecto positivo y la autoeficacia en pacientes con ECV, encontrándose diferencias intragrupo y entre grupos. El tercer estudio es un ensayo clínico piloto no aleatorizado, que tiene como objetivo diseñar y evaluar la efectividad de una intervención mHealth multicomponente en autoeficacia para mejorar el bienestar subjetivo y la autoeficacia para el manejo de la enfermedad cardíaca y crónica, analizando además posibles diferencias entre hombres y mujeres. Para este estudio, la muestra estaba compuesta por 42 pacientes cardiovasculares, que participaron equitativamente en un grupo experimental o control. Esta intervención multicomponente fue diseñada en base a la autoeficacia (Bandura, 1986a) e incluye una sesión presencial personalizada y una intervención mHealth de 14 días. Al igual que en el segundo estudio, ambos grupos fueron evaluados en repetidas ocasiones, con dos evaluaciones follow-ups que permitieron hacer comparaciones entre grupos e intragrupo, y ofrecer información más precisa acerca de la efectividad de la intervención. Los resultados mostraron que esta fue efectiva para mejorar el afecto positivo y la autoeficacia para el manejo de la enfermedad en pacientes cardiovasculares. Sin embargo, cuando se analizaron los datos por sexo, se observó que esta efectividad se daba únicamente en la población masculina. En conjunto, los resultados derivados de los tres estudios que conforman la presente tesis doctoral ponen de manifiesto la necesidad de incorporar el modelo biopsicosocial, así como la perspectiva de género, para comprender los procesos de salud enfermedad y abordar el diagnóstico y tratamiento de enfermedades de largo alcance como lo son las ECV, y su relación con la salud mental. Por su parte, los estudios empíricos aportan evidencia en favor de las vertientes terapéuticas que demandan la inclusión de la psicología en la rehabilitación cardíaca, además de la incorporación de nuevas estrategias de intervención que garanticen la accesibilidad de la atención sanitaria a este tipo de pacientes. Se considera que investigaciones futuras, por otro lado, deberían poner el foco en cómo establecer intervenciones online sin perder el contacto humano, así como tratar de adentrarse completamente en la personalización de estas intervenciones buscando evitar las diferencias en efectividad para las mujeres y la obtención de mejores resultados terapéuticos.The epidemiological transition in Western countries has led to major changes in morbidity and mortality patterns, with an exponential increase in non-communicable diseases (NCDs). This led to a change in the conception of health towards a more integrative perspective, in which biopsychosocial factors were necessary to explain the health disease processes and people, therefore, became active agents, responsible rather than mere passive subjects waiting to receive medication. Cardiovascular diseases (CVD) are the most prevalent set of NCDs with the highest mortality rate worldwide. They have historically been considered male diseases, although statistics show a higher mortality in women. This gender gap in CVD seems to be determined by a gender bias that affects diagnosis and intervention and makes a gender perspective necessary when addressing them. These diseases are a clear example of the need for a holistic approach to health, as the main cardiovascular risk factors are modifiable and, therefore, preventable. One of the objectives of Health Psychology is precisely to understand the underlying factors that influence healthy behaviour of these patients in order to promote them. In this direction, numerous investigations have related healthy behaviours to psychological variables, such as self-efficacy, adequate emotional regulation or psychological well-being, which are linked to greater therapeutic commitment and healthy lifestyle changes. In turn, CVD has been found to be associated with high levels of anxiety, stress and depression, which are also related to a worse prognosis of the disease and a poorer quality of life in these patients. Due to this relationship between psychological factors and cardiovascular health determinants, interventions aimed at promoting these psychological variables with the objective of improving their adjustment to the disease and reducing cardiovascular risk are deemed necessary. In this line, and based on the promising results of telemedicine to promote healthy behaviours, it is necessary to know whether this type of intervention would be effective in improving the aforementioned psychological variables in patients with CVD. Similarly, the health gap between women and men makes it necessary to implement a gender perspective in research and intervention. For all of the above reasons, the aim of this doctoral thesis is to deepen the analysis of the psychosocial factors that affect health and are related to CVD, as well as to test the effectiveness of mHealth interventions to promote the psychological variables related to healthy behaviours and psychological well-being in these patients. Thus, a series of investigations are proposed. These investigations have materialised in the publication of three independent and interrelated scientific articles, which are presented below. The first study is a systematic review that aims to explore the psychosocial factors that have been studied to explain the differential vulnerability of psychological well-being in women and men. Based on a biopsychosocial model, complemented by the gender perspective, studies assessing sex and gender differences in anxiety and its comorbidity were included. Following the PRISMA methodology, a systematic search was conducted in the electronic databases PubMed and PsicInfo, incorporating empirical studies and reviews published between 2008 - 2021. Following the search, 44 studies were included, which were analysed and classified according to the object of study. Finally, a qualitative narrative synthesis of the results was conducted. The results of the included studies showed that differences in psychological vulnerability between the sexes have historically been analysed on the basis of biological factors or psychosocial factors, but few studies have addressed the problem by alluding to both factors together. The second study aims to evaluate the effectiveness of an mHealth psychological intervention in emotional regulation to improve positive affect and self-efficacy in patients with CVD. To this end, a two-arm, non-randomised controlled trial was designed, in which the sample of 69 CVD patients was assigned to either the experimental group or the control or treatment-as-usual group. The intervention, based on the emotional regulation process (Gross, 1998; Leahy, 2011), consists of two phases, a face-to-face session and a second 14-day mHealth phase. Both groups were assessed multiple times on positive affect and self-efficacy (chronic and cardiac), including two follow-ups, which allowed for a repeated measures analysis. The results indicate that the mHealth psychological intervention was effective in improving positive affect and self-efficacy in patients with cardiovascular disease, with intra-group and between-group differences found. The third study is another pilot non-randomised clinical trial, which aims to design and evaluate the effectiveness of a multicomponent mHealth intervention on self-efficacy in improving subjective well-being and self-efficacy for the management of cardiac and chronic disease, also analysing possible differences between men and women. For this study, the sample consisted of 42 cardiovascular patients, who were equally assigned to the control or experimental group. This multicomponent intervention was designed on the basis of self-efficacy (Bandura, 1986a) and included a face-to-face one-to-one session and a 14-day mHealth intervention. As in the second study, both groups were repeatedly evaluated, with two follow-up assessments allowing for between-group and within-group comparisons and providing more accurate information about the effectiveness of the intervention. The results showed that the intervention was effective in improving positive affect and self-efficacy for disease management in cardiovascular patients. However, when the data were analysed by gender, this effectiveness was found to occur only in the male population. Taken together, the results derived from the three studies that constitute this doctoral thesis highlight the need to incorporate the biopsychosocial model, as well as a gender perspective, in order to understand health-disease processes and to address the diagnosis and treatment of long-term diseases, such as CVD, and their relation with mental health. With regards to the empirical studies, they provide evidence in favor of the therapeutic aspects that demand the inclusion of psychology in cardiac rehabilitation, as well as the incorporation of new intervention strategies that guarantee the accessibility of health care for these patients. Future research, on the other hand, should focus on how to establish online interventions without losing human contact, as well as try to fully explore the personalization of these interventions in order to avoid differences in effectiveness for women and to obtain better therapeutic results

Health, stress and technologies: integrating technology acceptance and health belief models for smartphone-based stress intervention

Work-related stress significantly jeopardizes employees’ physical and mental health due to the considerable time they spend at work. Smartphone-based interventions provide a promising solution, eliminating traditional face-to-face interventions’ barriers. However, the elements that influence workers’ intentions to use this still remain unexplored. This study explores the link between health belief model (HBM) and technology acceptance model (TAM) factors. In this study, 336 Italian workers (64% female) answered an online questionnaire. We employed a structural equation model (SEM) to analyze the data. The results unveiled an indirect relationship: individuals perceiving health risks were more inclined to use stress-management apps, mediated by perceived utility (PU). This study underscores the significant potential of integrating the HBM with the TAM in predicting users’ preparedness for smartphone-based health interventions. These findings not only hold substantial value but also illuminate a path forward for professionals and organizations, offering insights to tailor and optimize smartphone tools for stress management and the promotion of workplace well-being. Ultimately, this research paves the way for the cultivation of healthier work environments, marking a noteworthy contribution to the field

Positivity and health locus of control: key variables to intervene on well-being of cardiovascular disease patients

Psychological well-being is a good predictor of several health outcomes in cardiovascular disease patients (adherence, quality of life, and healthy behaviors). The perception of health control and a positive orientation seem to have a beneficial effect on health and well-being. Therefore, the aim of this study was to investigate the role of the health locus of control and positivity in the psychological well-being and quality of life of cardiovascular patients. A total of 593 cardiac outpatients completed the Multidimensional Health Locus of Control Scale, the Positivity Scale and the Hospital Anxiety and Depression Scale at baseline (January 2017) and 9 m later (follow-up; n = 323). A Spearman rank correlation coefficient and a structural equation modeling approach were determined to explore the relationships between those variables both cross-sectionally and longitudinally. A cross-sectional correlation analysis at baseline revealed that the internal health locus of control and positivity were negatively associated with anxiety (rs = −0.15 and −0.44, ps < 0.01) and depression (rs = −0.22 and −0.55, ps < 0.01) and positively associated with health-related quality of life (rs = 0.16 and 0.46, ps < 0.01). Similar outcomes were found at follow-up and in longitudinal correlations. According to the path analysis, positivity was found to be negatively associated with anxiety and depression level at baseline (β = −0.42 and −0.45, ps < 0.001). Longitudinally, positivity was negatively associated with depression (β = 0.15, p < 0.01) and together with the internal health locus of control, was positively associated with health-related quality of life (β = 0.16 and 0.10, respectively, ps < 0.05). These findings suggest that focusing on the health locus of control and especially positivity may be crucial in enhancing the psychological well-being of patients in the context of cardiac care. The potential impact of these results on future interventions is discussed

El rol moderador de la eficacia percibida de las medidas de prevención frente al COVID-19 en la relación entre la percepción de riesgo y la salud mental percibida

The pandemic situation caused by COVID-19 led countries to adopt harsh and prolonged (over time) measures that—along with the high number of infections and deaths and continuous negative information—have affected the mental health of individuals. In this study, the impact on mental health of the COVID-19 health crisis in Spain was explored through the perceived efficacy of pandemic containment measures as a moderator of the relationship that COVID-19 perceived risk establishes with stress and depression. A questionnaire composed of scales conceived to measure COVID-19 perceived risk, perceived efficacy of COVID-19 prevention measures, stress, and depression was completed by 478 adults living in Spain (66.9% females, Mage= 36.30, SD= 15.32) between May 16, 2021, and June 6, 2021. The results confirmed the moderating role of per-ceived efficacy. Perceived efficacy acted as a protective factor for stress and depression by decreasing the negative impact that perceived risk had on both variables related to mentaldistress. Also, the perception that participants had about the effectiveness of prevention measures appeared to be a relevant protective factor regarding mental health during the pandemic. This study highlights the relevance of psychological interventions and government policies that improve positive risk communication and provide adequate information regarding the effectiveness of health-prevention measuresLa pandemia del COVID-19 ha llevado a los países a adoptar severas y prolongadas medidas que junto con el alto número de contagios y muertes y la continua información negativa ha afectado la salud mental de las personas. Este estudio analiza el impacto de la crisis sanitaria del COVID-19 en España explorando el rol moderador de la eficacia percibida de las medidas de contención en la relación que establece la percepción del riesgo del COVID-19 con el estrés y la depresión. Un total de 478 adultos residentes en España (un66.9% mujeres; Medad= 36.30, DT= 15.32) completaron un cuestionario con escalas concebidas para medir el riesgo percibido del COVID-19, la eficacia percibida de las medidas de protección, el estrés y la depresión entre el 16 de mayo y el 6 de junio de 2021. Los resultados confirmaron el rol moderador de la eficacia percibida, la cual actuó como un factor protector del estrés y la depresión al disminuir el impacto negativo que la percepción de riesgo del COVID-19 tiene en ambas variables relacionadas con el distrés mental. La percepción que tienen los individuos sobre la efectividad de las medidas de protección parece ser un factor protector relevante en relación con la salud mental durante una pandemia. Se subraya la relevancia de intervenciones psicológicas y de políticas gubernamentales que mejoren la comunicación positiva del riesgo y la información adecuada sobre la eficacia de las medidas de protección

A Brief mHealth-Based Psychological Intervention in Emotion Regulation to Promote Positive Subjective Well-Being in Cardiovascular Disease Patients: A Non-Randomized Controlled Trial

The emotional impact that a cardiovascular disease may have on a person’s life can affect the prognosis and comorbidity of the disease. Therefore, emotion regulation is most important for the management of the disease. The aim of this study was to analyze the effectiveness of a brief mHealth psychological intervention in emotion regulation to promote positive subjective well-being in cardiovascular disease patients. The study sample (N = 69, 63.7 ± 11.5 years) was allocated to either the experimental group (n = 34) or control group (n = 35). The intervention consisted of a psychoeducational session in emotion regulation and an mHealth-based intervention for 2 weeks. Positive subjective well-being as a primary outcome and self-efficacy to manage the disease as a secondary outcome were assessed at five time points evaluated over a period of 6 weeks. The experimental group showed higher improvement in positive subjective well-being and self-efficacy for managing the disease compared to the control group over time. The experimental group also improved after the intervention on all outcome measures. Brief mHealth interventions in emotion regulation might be effective for improving positive subjective well-being and self-efficacy to manage the disease in cardiovascular patients

A Brief mHealth-Based Psychological Intervention in Emotion Regulation to Promote Positive Subjective Well-Being in Cardiovascular Disease Patients: A Non-Randomized Controlled Trial.

The emotional impact that a cardiovascular disease may have on a person's life can affect the prognosis and comorbidity of the disease. Therefore, emotion regulation is most important for the management of the disease. The aim of this study was to analyze the effectiveness of a brief mHealth psychological intervention in emotion regulation to promote positive subjective well-being in cardiovascular disease patients. The study sample (N = 69, 63.7 ± 11.5 years) was allocated to either the experimental group (n = 34) or control group (n = 35). The intervention consisted of a psychoeducational session in emotion regulation and an mHealth-based intervention for 2 weeks. Positive subjective well-being as a primary outcome and self-efficacy to manage the disease as a secondary outcome were assessed at five time points evaluated over a period of 6 weeks. The experimental group showed higher improvement in positive subjective well-being and self-efficacy for managing the disease compared to the control group over time. The experimental group also improved after the intervention on all outcome measures. Brief mHealth interventions in emotion regulation might be effective for improving positive subjective well-being and self-efficacy to manage the disease in cardiovascular patients

A Brief mHealth-Based Psychological Intervention in Emotion Regulation to Promote Positive Subjective Well-Being in Cardiovascular Disease Patients: A Non-Randomized Controlled Trial

The emotional impact that a cardiovascular disease may have on a person&rsquo;s life can affect the prognosis and comorbidity of the disease. Therefore, emotion regulation is most important for the management of the disease. The aim of this study was to analyze the effectiveness of a brief mHealth psychological intervention in emotion regulation to promote positive subjective well-being in cardiovascular disease patients. The study sample (N = 69, 63.7 &plusmn; 11.5 years) was allocated to either the experimental group (n = 34) or control group (n = 35). The intervention consisted of a psychoeducational session in emotion regulation and an mHealth-based intervention for 2 weeks. Positive subjective well-being as a primary outcome and self-efficacy to manage the disease as a secondary outcome were assessed at five time points evaluated over a period of 6 weeks. The experimental group showed higher improvement in positive subjective well-being and self-efficacy for managing the disease compared to the control group over time. The experimental group also improved after the intervention on all outcome measures. Brief mHealth interventions in emotion regulation might be effective for improving positive subjective well-being and self-efficacy to manage the disease in cardiovascular patients

Factors associated with gender and sex differences in anxiety prevalence and comorbidity: A systematic review.

Background: The prevalence and comorbidity of anxiety disorders are significantly different between women and men, with research showing a greater impact on women. The aim of this review was to identify the psychosocial and biological factors that have been considered to explain this gender and sex difference in prevalence and determine whether these factors are related to any anxiety comorbidity differences between men and women. Methods: Following the PRISMA guidelines, we carried out a systematic review of studies published between 2008 and 2021 in PsycINFO and PubMed databases. Empirical and review studies evaluating psychosocial and biological factors that could influence the difference in prevalence and comorbidity between men and women were included. A qualitative narrative synthesis was performed to describe the results. Results: From 1012 studies, 44 studies were included. Retrieved articles were categorized depending on their object of study: psychosocial factors (n = 21), biological factors (n = 16), or comorbidity (n = 7). Results showed that differences in anxiety between women and men have been analyzed by psychosocial and biological factors but rarely together. Among the psychosocial factors analyzed, masculinity may be a protective factor for anxiety development, while femininity can be a risk factor. In the studies that took biological factors into account, the potential influence of brain structures, genetic factors, and fluctuations in sexual hormones are pointed out as causes of greater anxiety in women. Concerning comorbidity, the results noted that women tend to develop other internalizing disorders (e.g. depression), while men tend to develop externalizing disorders (e.g. substance abuse). Conclusions: For an accurate understanding of differences between women and men in anxiety, both biological and psychosocial factors should be considered. This review highlights the need to apply the biopsychosocial model of health and the gender perspective to address differences in anxiety between sexes

Combining robot-assisted therapy with virtual reality or using it alone? A systematic review on health-related quality of life in neurological patients

Abstract Background In the field of neurorehabilitation, robot-assisted therapy (RAT) and virtual reality (VR) have so far shown promising evidence on multiple motor and functional outcomes. The related effectiveness on patients’ health-related quality of life (HRQoL) has been investigated across neurological populations but still remains unclear. The present study aimed to systematically review the studies investigating the effects of RAT alone and with VR on HRQoL in patients with different neurological diseases. Methods A systematic review of the studies evaluating the impact of RAT alone and combined with VR on HRQoL in patients affected by neurological diseases (i.e., stroke, multiple sclerosis, spinal cord injury, Parkinson’s Disease) was conducted according to PRISMA guidelines. Electronic searches of PubMed, Web of Science, Cochrane Library, CINAHL, Embase, and PsychINFO (2000–2022) were performed. Risk of bias was evaluated through the National Institute of Health Quality Assessment Tool. Descriptive data regarding the study design, participants, intervention, rehabilitation outcomes, robotic device typology, HRQoL measures, non-motor factors concurrently investigated, and main results were extracted and meta-synthetized. Results The searches identified 3025 studies, of which 70 met the inclusion criteria. An overall heterogeneous configuration was found regarding the study design adopted, intervention procedures and technological devices implemented, rehabilitation outcomes (i.e., related to both upper and lower limb impairment), HRQoL measures administered, and main evidence. Most of the studies reported significant effects of both RAT and RAT plus VR on patients HRQoL, whether they adopted generic or disease-specific HRQoL measures. Significant post-intervention within-group changes were mainly found across neurological populations, while fewer studies reported significant between-group comparisons, and then, mostly in patients with stroke. Longitudinal investigations were also observed (up to 36 months), but significant longitudinal effects were exclusively found in patients with stroke or multiple sclerosis. Finally, concurrent evaluations on non-motor outcomes beside HRQoL included cognitive (i.e., memory, attention, executive functions) and psychological (i.e., mood, satisfaction with the treatment, device usability, fear of falling, motivation, self-efficacy, coping, and well-being) variables. Conclusions Despite the heterogeneity observed among the studies included, promising evidence was found on the effectiveness of RAT and RAT plus VR on HRQoL. However, further targeted short- and long-term investigations, are strongly recommended for specific HRQoL subcomponents and neurological populations, through the adoption of defined intervention procedures and disease-specific assessment methodology

Effectiveness of Mindfulness and Positive Strengthening mHealth Interventions for the Promotion of Subjective Emotional Wellbeing and Management of Self-Efficacy for Chronic Cardiac Diseases

Intervention in health prevention and treatment via mobile phones is becoming a key element on health promotion. Testing the efficacy of these mobile health (mHealth) psychological interventions for cardiovascular health is necessary as it is a chronic pathology, and it can influence the affective and cognitive states of patients. This research aimed to analyze the effectiveness of two brief psychological interventions—mindfulness and positive strengthening—to promote subjective emotional wellbeing and disease management self-efficacy using mHealth. This was a three-arm intervention and feasibility study, with a pre-post design and three follow-up measures with 105 patients (93 completed all phases) with cardiovascular diseases. Group 1 and 2 received the mindfulness or strengthening intervention, and Group 3 was the control group. The positive–negative affect and management self-efficacy for chronic and cardiovascular diseases were analyzed over time, while anxiety and depression levels were assessed at the beginning of the study. The results showed that mindfulness and positive strengthening interventions both had a positive effect on participants’ affective state and management self-efficacy for the disease in comparison with the control group over time, even after controlling for baseline anxiety and depression levels. Positive strengthening seems to be more effective for improving cardiac self-efficacy, while mindfulness practice was significantly more effective at reducing negative affect at the first face-to-face evaluation