Baseline characteristics in fallers and non-fallers.

<p><i>Notes</i>: BMI = body mass index; OA = osteoarthritis; TUG = timed up and go; FR = functional reach.</p><p>Baseline characteristics in fallers and non-fallers.</p

Comparison of WOMAC symptom severity scores between fallers and non-fallers according to osteoarthritis diagnosis.

<p><i>Notes</i>: OA = osteoarthritis; IQR = interquartile range; NA = not applicable.</p><p>* Mann-Whitney U.</p><p>** Logistic regression with dummy variables. Categorized using percentile cut-offs from Total WOMAC Score. “No symptoms”: 0mm. “Mild”: 1-200mm. “Moderate”: 201-465mm. “Severe”: ≥466mm.</p><p>Comparison of WOMAC symptom severity scores between fallers and non-fallers according to osteoarthritis diagnosis.</p

Levels and ratio of CGB lectin bound proteins in normal control women and breast cancer patients.

<p>Percentage of volume was obtained using GelAnalyzer software. The percentage volume of each peptide band was compared using SPSS. (a) and (b) refer to mean % volumes of proteoglycan 4 and plasma protease C1 inhibitor, respectively. (c) The ratio of proteoglycan 4/plasma protease C1 inhibitor (PRG4/C1-inh) demonstrates higher fold-change difference between both the early stages of breast cancer compared to controls.</p

Levels of <i>O</i>-glycosylated proteins in serum perchloric acid (PCA) isolates.

<p>(a) The levels of <i>O</i>-glycosylated proteins were estimated using sandwich ELLA with asialoBSM as the standard <i>O</i>-glycosylated protein. (b) <i>O</i>-glycosylated proteins recovery assay was performed by spiking biotinylated-asialoBSM into serum samples and followed by PCA treatment. (●) Biotinylated-asialoBSM spiked into serum samples followed by PCA treatment; (■) Biotinylated-asialoBSM spiked into serum PCA isolates.</p

Western blot analysis of protease C1 inhibitor in serum PCA isolates of normal control women and breast cancer patients.

<p>CGB lectin bound proteins of serum PCA isolates were transferred onto nitrocellulose membrane and blotted using rabbit anti-plasma protease C1 inhibitor (a). Intensities of the bands were analysed using the GelAnalyzer software and volume intensity was compared across the three groups of samples analysed (b).</p

List of proteins present in serum PCA isolates.

<p>List of proteins present in serum PCA isolates.</p

CGB lectin isolated proteins of altered abundance.

<p>CGB lectin isolated proteins of altered abundance.</p

Estimation of total <i>O</i>-glycosylated protein in serum samples of cancer-free women (control) and patients with early stages of breast cancer.

<p>Serum samples were analysed by sandwich ELLA without (a) and after PCA treatment (b). The assay performance was evaluated by performing Receiver Operative Characteristic analysis on the level of <i>O</i>-glycosylated protein detected before and after serum treated with PCA. (c) and (d) refer to analysis of stage 0 and stage I serum samples, respectively.</p

Difference in square-root mammographic density measures with a 10-year difference in age, in pre- and postmenopausal women.

<p>Difference in square-root mammographic density measures with a 10-year difference in age, in pre- and postmenopausal women.</p

Association of square-root percent mammographic density with menopausal status and age.

<p>Associations of square-root percent density, by population group, with (a) menopausal status, (b) age among premenopausal women, and (c) age among postmenopausal women, meta-analysed overall and by ASR in source population (low, medium, high). Associations are adjusted for age (for [a] only), BMI, BMI2, parity, age at first birth, HRT use (never, current, former, ever, unknown), mammography view, and MD reader. Full names and details of studies/population groups presented in this figure are provided in <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1002335#pmed.1002335.s011" target="_blank">S1 Text</a>. Chile is excluded from (a) and (c) as all women were premenopausal. Norway, Australia (Greek), and Australia (Italian) were not included in (a) and (b) as all women were postmenopausal. Turkey was excluded from (a) as selection of women implied that age completely determined menopausal status. ASR, age-standardised incidence rate; BMI, body mass index; CI, confidence interval; HRT, hormone replacement therapy; MD, mammographic density; PD, percent mammographic density.</p