T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections

The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria. Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group. Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85. A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen

Etude sérologique de l'antigène lié au sexe mâle

Doctorat en sciences médicalesinfo:eu-repo/semantics/nonPublishe

Suicide cellulaire

This work was directly stimulated by Jean Claude Ameisen's, who thinks apoptosis ("cellular suicide") is responsible for CD4+ T cell dysfunction and loss in HIV infection, this apoptosis being induced by antigens "seen" before. We wanted to know if this work could be reproduced ; and it could, and also if it had clinical relevance (could it be triggered by exposure to recall antigens). We are currently under the opinion that HIV itself could be a more important contributor of the phenomenon than concurrent vaccines or infections. This paper also reviews more general considerations on the implications of cellular suicide (in embryogenesis, in the genesis of tumors).Farber Claire Michèle. Suicide cellulaire. In: Bulletin de la Classe des sciences, tome 4, n°1-6, 1993. pp. 25-28

Etude sérologique de l'antigène lié au sexe mâle

Doctorat en sciences médicalesinfo:eu-repo/semantics/nonPublishe

MIRO: A randomized trial of maintenance therapy with or without protease inhibitors after 4 month of triple or quadruple induction therapy

info:eu-repo/semantics/nonPublishe

Prospective Collection of Data on the Prevalence of Transmitted Resistance in Newly Diagnosed HIV-Infected Individuals in Belgium in 2004

info:eu-repo/semantics/nonPublishe

Prevalence of Transmitted Resistance in Newly Diagnosed HIV-Infected Individuals in Belgium Prospectively Collected Frim 2003 to 2005 is Significantly Higher Than 5%

info:eu-repo/semantics/nonPublishe