Theoretical and practical convergence of a self-adaptive penalty algorithm for constrained global optimization

This paper proposes a self-adaptive penalty function and presents a penalty-based algorithm for solving nonsmooth and nonconvex constrained optimization problems. We prove that the general constrained optimization problem is equivalent to a bound constrained problem in the sense that they have the same global solutions. The global minimizer of the penalty function subject to a set of bound constraints may be obtained by a population-based meta-heuristic. Further, a hybrid self-adaptive penalty firefly algorithm, with a local intensification search, is designed, and its convergence analysis is established. The numerical experiments and a comparison with other penalty-based approaches show the effectiveness of the new self-adaptive penalty algorithm in solving constrained global optimization problems.The authors would like to thank the referees, the Associate Editor and the Editor-in-Chief for their valuable comments and suggestions to improve the paper. This work has been supported by COMPETE: POCI-01-0145-FEDER-007043 and FCT - Funda¸c˜ao para a Ciˆencia e Tecnologia within the projects UID/CEC/00319/2013 and UID/MAT/00013/2013.info:eu-repo/semantics/publishedVersio

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

Impact of accounting for coloured noise in radar altimetry data on a regional quasi-geoid model

We study the impact of an accurate computation and incorporation of coloured noise in radar altimeter data when computing a regional quasi-geoid model using least-squares techniques. Our test area comprises the Southern North Sea including the Netherlands, Belgium, and parts of France, Germany, and the UK. We perform the study by modelling the disturbing potential with spherical radial base functions. To that end, we use the traditional remove-compute-restore procedure with a recent GRACE/GOCE static gravity field model. Apart from radar altimeter data, we use terrestrial, airborne, and shipboard gravity data. Radar altimeter sea surface heights are corrected for the instantaneous dynamic topography and used in the form of along-track quasi-geoid height differences. Noise in these data are estimated using repeat-track and post-fit residual analysis techniques and then modelled as an auto regressive moving average process. Quasi-geoid models are computed with and without taking the modelled coloured noise into account. The difference between them is used as a measure of the impact of coloured noise in radar altimeter along-track quasi-geoid height differences on the estimated quasi-geoid model. The impact strongly depends on the availability of shipboard gravity data. If no such data are available, the impact may attain values exceeding 10 centimetres in particular areas. In case shipboard gravity data are used, the impact is reduced, though it still attains values of several centimetres. We use geometric quasi-geoid heights from GPS/levelling data at height markers as control data to analyse the quality of the quasi-geoid models. The quasi-geoid model computed using a model of the coloured noise in radar altimeter along-track quasi-geoid height differences shows in some areas a significant improvement over a model that assumes white noise in these data. However, the interpretation in other areas remains a challenge due to the limited quality of the control data.Novel Aerospace MaterialsPhysical and Space Geodes