Potency of Piper crocatum Decoction as an Antihiperglycemia in Rat Strain Sprague dawley

Current researches for appropriate hypoglycemic agents focused on plants for traditional medicine. Traditionally in diabetic treatment, people used decoctions of Piper crocatum (Piperaceae). However, there is no phytochemical data of decoctions extract of P. crocatum. Hence, the aims of this study were to explore the phytochemical of P. crocatum decoctions and its antihyperglicemic activity. Fresh leaves of P. crocatum were boiled in water to obtain decoction and were examined phytochemical compounds by using Harbone assay. Antihyperglicemic activity of P. crocatum decoction extract was orally fed to alloxan induced diabetic rats. Results showed that P. crocatum decoction extract contained flavonoids, tanins, and alkaloids. Ten days of daily treatment of various doses decoction extract of P. crocatum led to reduce blood sugar level by 10-38% and prevent fall in body weight level by 5-52%. This result showed the same activity as Daonil treatment, which was the diabetic drug. Hence, this extract showed antihyperglicemic activity in alloxan-induced diabetic rats and increasing of their body weight

PENGGUNAAN METODE FMECA (FAILURE MODES EFFECTS CRITICALITY ANALYSIS) DALAM IDENTIFIKASI TITIK KRITIS DI INDUSTRI KEMASAN

XYZ is a company engaged in packaging, especially for pharmaceuticals. The company has recorded an overall defective product known as end to end waste. During 2019 the average end to end waste was 12.37%, while the target of company management was 9%. The objective of this research is to minimize defective products and to find out what types of defects occur in the production process. The method used in this research is FMECA (Failure Modes, Effects and Critically Analysis), which is the development of the FMEA (Failure Mode and Effect Analysis) method which functions to make analyzes from production tools or processes, types of defects to the effects that arise as a result. of the defect, but also to determine the critical point. The results of the analysis that has been carried out using the FMEA method with RPN (Risk Priority Number) calculations, then analysis with the Pareto diagram and criticality matrix, the researcher gets 10 priority failure modes, namely the machine often stops due to a lot of paper dust, too high piles, unstable colors because there is a change in ink, the non-stop feeder is damaged, the front lay and side lay are unstable from the printing process, the side lay sensor does not work, the actual chiller temperature with the display is not the same, the paper is untidy from the printing process, the paper is untidy from the calendering process, and the chiller is leaking. The researcher also gave recommendations, namely making a Standard Operation Procedure (SOP) for handling dusty paper, submitting complaints to suppliers regarding paper quality, providing a printing unit, and training for dusty paper handling. Keywords: criticality matrix, FMECA, risk priory number, pareto diagra

PERMODELAN MATEMATIKA EKSTRAKSI OLEORESIN TEMULAWAK (Curcuma Xanthorrizha Roxb) DENGAN KARBONDIOKSIDA SUPERKRITIS DAN CO-SOLVENT ETANOL MENGGUNAKAN SHRINKING CORE MODEL

AbstractThis experiment studied the extraction of oleoresin from Curcuma Xanthorrizha Roxb using supercritical carbon dioxide. Effects of various operation condition such as pressure, temperature, extractions time, and addition of ethanol-co-solvent into bulk carbon dioxide have been studied. Solubility of carbon dioxide could be increased by addition of co-solvent ethanol. Temperature and pressure affect solubility of oleoresin in carbon dioxide so that it may affect to oleoresin, and curcuminoid yield. Extraction temperature and pressure were performed at 45-65 oC and 10-18 MPa, respectively. Simulation study  that could describe the process of oleoresin extraction from Curcuma Xanthorhiza Roxb by supercritical carbon dioxide have been done using Shrinking Core Model. Fitting the calculated curve and experimental data done by trial the difference value of a and Bi, where a = (V/L) (R2/De) and Bi = (kf R/De). Effective inter particle diffusion value (De) and external mass transfer coefficient (kf) could be determined after trial value of a and Bi. At 14 Mpa, 50oC, with co-solvent, the resulted value of De is 6.572 x 10-11 and the value of kf is 1.2159 x 10-5 with error value 2.46 %. Keywords : modeling, supercritical carbon dioxide, Curcuma Xanthorrixa Roxb

PERMODELAN MATEMATIKA EKSTRAKSI OLEORESIN TEMULAWAK (Curcuma Xanthorrizha Roxb) DENGAN KARBONDIOKSIDA SUPERKRITIS DAN CO-SOLVENT ETANOL MENGGUNAKAN SHRINKING CORE MODEL

AbstractThis experiment studied the extraction of oleoresin from Curcuma Xanthorrizha Roxb using supercritical carbon dioxide. Effects of various operation condition such as pressure, temperature, extractions time, and addition of ethanol-co-solvent into bulk carbon dioxide have been studied. Solubility of carbon dioxide could be increased by addition of co-solvent ethanol. Temperature and pressure affect solubility of oleoresin in carbon dioxide so that it may affect to oleoresin, and curcuminoid yield. Extraction temperature and pressure were performed at 45-65 oC and 10-18 MPa, respectively. Simulation study  that could describe the process of oleoresin extraction from Curcuma Xanthorhiza Roxb by supercritical carbon dioxide have been done using Shrinking Core Model. Fitting the calculated curve and experimental data done by trial the difference value of a and Bi, where a = (V/L) (R2/De) and Bi = (kf R/De). Effective inter particle diffusion value (De) and external mass transfer coefficient (kf) could be determined after trial value of a and Bi. At 14 Mpa, 50oC, with co-solvent, the resulted value of De is 6.572 x 10-11 and the value of kf is 1.2159 x 10-5 with error value 2.46 %. Keywords : modeling, supercritical carbon dioxide, Curcuma Xanthorrixa Roxb

Strategi Pengembangan UMKM Pangan Berdaya Saing di Kota Bandung

SMEs (Micro-Small and Medium Enterprises) are one of business sector that has an important role for improving economy condition in Indonesia. One of the SMEs that has the potential to competition is food SMEs. To create food MSMEs that able to compete with the other food products, they must be able to maintain the quality of various aspects. The many problems faced by food SMEs require a strategy to develop and continue. This research aims to create competitiveness and strategy in food MSMEs. This research was conducted by identifying food MSMEs, analyse the influence of internal factors and external factors with the IE matrix, looking for the formulation of food SMEs strategies using SWOT and QSPM methods. The location of the research was conducted in the city of Bandung, West Java. The results of this research based on the IE matrix show that the Bandung City food UMKM requires a grow and build strategy. Based on the SWOT and QSPM methods, various alternative strategies were obtained. Strategy III is the most suitable strategy for Bandung's food UMKM with a value 6.433. Strategy III is "improving human resource capabilities, utilizing associations and government support to expand product markets". The level of diversity of food MSMEs in Bandung is high, that makes the characteristics of the commodities produced. The majority of business people rely heavily on the government in all aspects of business. Procurement of raw materials is carried out independently with a contract system and own business capita

TINJAUAN METODE POTENSIAL SINTESIS BIONANOKOMPOSIT ANTISTATIS YANG DIPERKUAT DENGAN MONO-DIASILGLISEROL DAN NANOKRISTAL SELULOSA

In the last 10 years, the research about the technology of bionanocomposite synthesis has increased rapidly,starting from the simple technology to advanced technology of synthesis. From the several technologies ofsynthesis of bionanocomposite that have been developed, each has its own advantages and disadvantages.Therefore, the selection of the right technology of synthesis of bionanocomposite is one of the indicators of successin its synthesis. This review identified the latest developments in technology of synthesis of bionanocomposite andfocuses on methods of synthesis of bionanocomposite was most widely used and a technology that has advantagesover other technologies. It is hoped that this review can provide information about methods of synthesis ofbionanocomposite in general and specifically can provide information about methods of synthesis ofbionanocomposite reinforced with mono-diacylglycerol (M-DAG) and cellulose nanocrystal (CNC). Based on theidentification from several result of research, potential method to synthesis of bionanocomposite are combinationof two methods, namely twin-screw extrusion method and injection molding method. Those technologies can be analternative potential methods of synthesis of antistatic bionanocomposite reinforced with M-DAG and CNC.Keywords: cellulose nanocrystal, injection molding, mono-diacylglycerol, technology of synthesis of antistaticbionanocomposite, twin-screw extrusio

ANALISIS PROKSIMAT DAN TOKSISITAS AKUT EKSTRAK DAUN SIRIH MERAH YANG BERPOTENSI SEBAGAI ANTIDIABETES

The aim of this study was to explore the analysis proximate and toxicity of the decoctions of P. crocatum. Fresh leaves of P. crocatum were boiled in water in order to obtain decoction and were examined for its chemical compounds by using SNI 01-2891-1992 method for proximate analysis. Toxicity of decoction extract of P. crocatum was orally fed to rats (Sprague dawley). The results showed that P. crocatum leaves contains 9.27% water, 14.33% ash, 3.96% fat, 22.63% proteins, and 59.08% carbohydrates. Acute toxicity test showed that all rats were still alive after 7 days treatment with P. crocatum decoction for all dose groups (0, 5, 10, and 20 g/kg BB). LC50 value of P. crocatum decoction was 544.82 ppm, meaning that the decoction was relatively harmless and bioactive

KARAKTERISTIK MIKROKAPSUL ANTOSIANIN UBI JALAR UNGU DENGAN TEKNIK SPRAY DRYING

Anthocyanin is a source of natural dyes that can replace synthetic dyes. Its nature which is susceptible to certain environmental conditions limits its usefulness in food processing, so it is necessary to encapsulate it in a matrix in the form of microencapsulation. Anthocyanin was extracted from purple sweet potato. Encapsulation was carried out by spray drying technique with the matrix carboxymethyl starch (CMS) and sodium alginate. The matrix combinations used were 1% CMS, CMS-alginate (0.75%: 0.25%), and CMS-alginate (0.5%: 0.5%). The aim of this work was to obtain the physical and morphological characteristics of purple sweet potato anthocyanin microcapsules in each matrix combination. The results of the purple sweet potato anthocyanin micro encapsulation using spray dyring technique showed that microcapsules with CMS matrix of 1% had the highest efficiency encapsulation (EE) and yield of 99.37 ± 0.49% and 58.52 ± 0.23% respectively. Purple sweet potato anthocyanin microcapsules with CMS 1% matrix gave the best thermal stability compared to CMS-alginate matrix (0.5% : 0.5%) and CMS-alginate (0.75% : 0.25%). The average particle size for purple sweet potato anthocyanin microcapsules from various matrices ranged from 4.2-4.8 µm with a rounded shape.Keywords: anthocyanin, microcapsule, CMS, alginate,  spray dryin

Teknik Ekstraksi dan Nanoenkapsulasi Komponen Bioaktif Buah Malaka: Tinjauan Literatur

The bioactive components of malacca (Emblica officinalis), which consist of phenolic, alkaloids, phytosterols, organic acids, and vitamins, are valuable for human health. The yield and quality of the bioactive components in the extract highly depend on the extraction technique, so it is essential to know the development of research on extraction techniques of the bioactive components of malacca fruit. In addition, the bioactive components in the extract have limitations in their application due to their stability, solubility, absorption, and bioavailability properties. Currently, nanoencapsulation technology has been applied to extracts of bioactive components to improve their properties. This review aims to provide comprehensive information about extraction techniques to obtain bioactive components of malacca fruit and presents the technique and purpose of the nanoencapsulation of malacca fruit extract. In addition to conventional techniques, several modern extraction techniques such as microwave-assisted extraction (MAE), ultrasound (UAE), pulsed electric field (PEF), and supercritical fluid (SFE) have been used to extract bioactive components of malacca fruit. Modern extraction techniques can produce extracts of bioactive components with higher yields than conventional techniques. The application of nanoencapsulation technology to malacca fruit extract consists of nanoliposomes and nanoparticles can increase permeability, antioxidant activity, antidiabetic and anti-inflammatory properties of malacca fruit extract

SIFAT FISIK DAN MEKANIK PAPAN PARTIKEL DARI BUNGKIL BIJI JARAK PAGAR

Bungkil biji jarak pagar adalah salah satu produk samping (by-product) dari pengolahan biji jarak pagarmenjadi minyak jarak dan biodiesel, yang saat ini belum dimanfaatkan secara optimal. Sebagai by-productdengan kandungan protein (18%) dan serat (39%) yang tinggi, bungkil biji jarak pagar memiliki potensi untukdimanfaatkan sebagai bahan baku papan partikel. Tujuan penelitian ini adalah untuk mengetahui sifat fisik danmekanik papan partikel yang diproduksi dari bungkil biji jarak pagar, dan mengetahui pengaruh perlakuanvariasi kadar air bungkil (7%, 20%), konsentrasi gliserol (0%, 4%) dan waktu pengukusan bungkil (0, 30, 60menit) terhadap mutu papan partikel. Adapun standar pengujian yang digunakan adalah JIS A 5908-2003. Hasilpenelitian menunjukkan bahwa kadar air bungkil, konsentrasi gliserol dan waktu pengukusan mempengaruhisifat fisik dan mekanik papan partikel. Namun demikian, hanya peningkatan kadar air bungkil yang berpengaruhsecara signifikan terhadap peningkatan mutu papan partikel. Pada 2 taraf kadar air bungkil yang diuji dalam studiini, semakin tinggi kadar air bungkil, kerapatan, kekuatan lentur dan keteguhan patah papan partikel semakinmeningkat, sedangkan daya serap airnya cenderung menurun. Sifat fisik dan mekanik papan partikel dari bungkilbiji jarak pagar secara umum belum memenuhi standar JIS A 5908-2003 dan belum sesuai untukpemanfaatannya sebagai material konstruksi.Kata kunci: papan partikel, bungkil, jarak pagar, kekuatan lentur, keteguhan pata