9 research outputs found
Rapid On-Site Evaluation Does Not Improve Endoscopic Ultrasound-Guided Fine Needle Aspiration Adequacy in Pancreatic Masses: A Meta-Analysis and Systematic Review - Fig 7
<p>Results for the non-ROSE group in individual studies and from pooled data shown as forest plots for: <b>a</b> sensitivity; <b>b</b> specificity. The <i>I</i><sup>2</sup> result for heterogeneity is also stated (CI, confidence interval; df, degrees of freedom).</p
Rapid On-Site Evaluation Does Not Improve Endoscopic Ultrasound-Guided Fine Needle Aspiration Adequacy in Pancreatic Masses: A Meta-Analysis and Systematic Review
<div><p>Background and Objectives</p><p>Rapid on-site evaluation (ROSE) during endoscopic ultrasonography-guided fine needle aspiration (EUS–FNA) of pancreatic masses has been reported to be associated with improved adequacy and diagnostic yield. However, recent observational data on the impact of ROSE have reported conflicting results. A meta-analysis and systematic review was therefore conducted to evaluate the contribution of ROSE during EUS-FNA of pancreatic masses.</p><p>Method</p><p>A systematic search was conducted in MEDLINE/Pubmed and EMBASE databases for studies comparing the efficacy of ROSE between patients in two cohorts. Outcomes considered included diagnostic adequate rate, diagnostic yield, number of needle passes, pooled sensitivity and specificity. Findings from a random-effects model were expressed as pooled risk difference (RD) with 95% confidence intervals (CIs).</p><p>Results</p><p>A total of 7 studies (1299 patients) was finally included and further analyzed in the current meta-analysis. EUS-FNA with ROSE could not improve diagnostic adequacy (RD = 0.05, 95% CI: -0.01–0.11) and diagnostic yield (RD = 0.04 95%CI: -0.05, 0.13). The number of needle passes showed no statistically significant difference with and without ROSE (RD = -0.68 95%CI: -2.35, 0.98). The pooled sensitivity and specificity of ROSE group were 0.91 (95%CI: 0.87, 0.94) and 1 (95%CI: 0.94, 1.00). The pooled sensitivity and specificity of non-ROSE group were 0.85 (95%CI: 0.80, 0.89) and 1 (95%CI: 0.95, 1.00). ROSE group and non-ROSE group showed comparable sensitivity and specificity.</p><p>Conclusion</p><p>Compared to historical reports of its clinical efficacy in patients with pancreatic lesions, ROSE may be not associated with an improvement of diagnostic yield, adequate rate, pooled sensitivity and specificity.</p></div
Forest plot displaying the Risk Difference and 95% CIs of each study for the adequacy rate.
<p>Forest plot displaying the Risk Difference and 95% CIs of each study for the adequacy rate.</p
Forest plot displaying the Risk Difference and 95% CIs of each study for the diagnosis yield.
<p>Forest plot displaying the Risk Difference and 95% CIs of each study for the diagnosis yield.</p
Flow chart of literature search and selection.
<p>Flow chart of literature search and selection.</p
Weighted summary receiver operating characteristic (SROC) curve, with 95% confidence interval (CI), for studies involved.
<p><b>a</b> ROSE group; <b>b</b> non-ROSE group.</p
Diagnostic performance for individual studies of meta-analysis comparing EUS-FNA with and without ROSE.
<p>Diagnostic performance for individual studies of meta-analysis comparing EUS-FNA with and without ROSE.</p
Forest plot displaying the Risk Difference and 95% CIs of each study for the diagnosis yield of malignancy.
<p>Forest plot displaying the Risk Difference and 95% CIs of each study for the diagnosis yield of malignancy.</p
Forest plot displaying the impact of assessor type to adequacy rate.
<p>Forest plot displaying the impact of assessor type to adequacy rate.</p