12 research outputs found
Associations of Apolipoprotein A, High-Sensitivity C-Reactive Protein and Fasting Plasma Insulin in Obese Children With and Without Family History of Cardiovascular Disease
BACKGROUND: The worldwide prevalence of childhood obesity has increased from 4.2% to 6.7% during the last two decades. Pediatric obesity is a major health problem, which is dramatically increasing in Greece. A variety of inflammatory variables have been also found to associate with cardiometabolic (CV) risk in obese children. The purpose of this study was to identify and examine the effects of possible CV risk factors in obese and non-obese children with and without family history (FH) of cardiovascular disease (CVD). METHODS: Sixty-eight (68) healthy children and adolescents aged 7 - 13 years participated in the study. Anthropometrical and biochemical indexes were obtained from all children as well as FH of CVD. RESULTS: Systolic blood pressure (SBP), total cholesterol (TC), triglyceride (TG), high-sensitivity C-reactive protein (hsCRP), fasting plasma insulin (FPI) and homeostasis model assessment of insulin resistance (HOMA-IR) levels were found statistically significantly higher in the obese group compared to the non-obese one. High-density lipoprotein (HDL) levels were observed to be statistically significantly lower in the obese children compared to their normal peers. CONCLUSIONS: Apolipoprotein A, hsCRP and FPI levels were significantly higher in the obese children with FH of CVD compared to the ones without FH of CVD. TC and SBP were found to be independently associated with obesity (odds ratio (OR): 1.965, 95% confidence interval (CI): 1.935 - 2.97, P \u3c 0.031 and OR: 1.045, 95% CI: 1.016 - 1.074, P \u3c 0.002, respectively)
Rare non-Wilms' tumors in children
We report our institutional experience of the management of 2 cases of rare non-Wilms' tumors; a rhabdoid tumor in a 17-month old boy and a clear cell sarcoma in a 5-year old girl. The two patients were treated with ifosfamide/carboplatin/etoposide (ICE) alternating with vincristine/doxorubicin/cyclophosphamide (VDC) and cyclophosphamide/etoposide (CE) alternating with vincristine/doxorubicin/cyclophosphamide (VDC) and radiotherapy, respectively. Both patients showed full response with no significant adverse events. At 2-year follow up, they are disease and relapse free. Although contemporary treatment regimens are very promising, multicenter collaborative studies are needed in order to define a standard treatment for non-Wilms' tumors
Transient myeloproliferative disorder in a newborn with down syndrome treated with rasburicase for the risk of development of tumor lysis syndrome: A case report
Abstract Introduction Transient myeloproliferative disorder is a hematologic abnormality characterized by an uncontrolled proliferation of myeloblasts in peripheral blood and bone marrow that primarily affects newborns and babies with Down syndrome. Tumor lysis syndrome is rarely associated with transient myeloproliferative disorder. Case presentation Transient myeloproliferative disorder was diagnosed in a seven-day-old baby girl with Down syndrome, who was referred to our department due to hyperleukocytosis. Our patient developed tumor lysis syndrome, successfully treated with rasburicase, as a complication of transient myeloproliferative disorder resulting from rapid degradation of myeloid blasts after initiation of effective chemotherapy. Conclusions Tumor lysis syndrome is rarely reported as a complication of transient myeloproliferative disorder. To the best of our knowledge, this is the first case of a newborn with Down syndrome and transient myeloproliferative disorder treated with rasburicase for developing tumor lysis syndrome.</p
Bacteremia in Children with Acute Lymphoblastic Leukemia: A Five-year Experience in Pediatric Hematology- Oncology Unit in Northern Greece
Atrial septal aneurysms in childhood: prevalence, classification, and concurrent abnormalities
Socioeconomic status, area remoteness, and survival from childhood leukemia: results from the Nationwide Registry for Childhood Hematological Malignancies in Greece
The aim of the present nationwide Greek study is to assess whether
survival from acute lymphoblastic leukemia (ALL) and acute myeloid
leukemia (AML) is modified by socioeconomic status (SES) and area
remoteness. Detailed precoded information derived from a personal
interview conducted by specially trained health personnel with the child
guardians was available for 883 ALL and 111 AML incident childhood cases
registered in the Nationwide Registry for Childhood Hematological
Malignancies during the period 1996-2010. Parental socioprofessional
category was recorded on the basis of ISCO68 and ISCO88 codes; the exact
traveling distance between residence and the treating hospital was ad
hoc calculated. Multivariate Cox’s proportional hazards models were
applied to examine the mutually adjusted associations between survival
and potential predictors. Children from a lower parental
socioprofessional category experienced 40% worse survival (P=0.02)
independent of age, sex, and ALL subtype, whereas those whose parents
were married had better outcomes (rate ratio: 0.47, P=0.01).
Urbanization of residence at diagnosis or residence to treating
hospital’ distance was not nominally associated with survival from ALL.
By contrast, no noteworthy associations implicating SES were found for
AML survival, probably because of the burden of the disease and small
numbers. Lower SES indicators and a single-parenthood family milieu seem
to be independently associated with unfavorable outcomes from childhood
ALL. Area remoteness might not be a significant outcome predictor during
recent years, following considerable improvements in the motorway
infrastructures and care delivery patterns. This study may provide a
valuable snapshot capturing the impact of socioeconomic covariates
before the burst of the Greek financial crisis. (C) 2013 Wolters Kluwer
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