Marx for his times. Book Review of: 'Karl Marx : greatness and illusion' by Gareth Stedman Jones

Potential downstream targets for CD274. RNA-sequencing was performed with WT and CD274-null LICs, and the candidate genes related to proliferation and cell cycle was analyzed. (PDF 116 kb

Additional file 1: of Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization

Supplementary Tables. Table S1 Demographic and general characteristics of the study participants. Table S2 General characteristics of the study population by blood lead quartiles. (DOC 101 kb

Additional file 1: Table S1. of Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population

AUC(95%CI) of markers for insulin resistance (HOMA-IR>2) in subjects categorized by WC. Table S2. Linear regression analysis for the correlation of ALT/AST ratio and other potential metabolic factors with HOMA-IR. Table S3. Associations of insulin resistance (HOMA-IR >2) with ALT/AST ratio and other potential metabolic factors in logistic regression analyses. (DOCX 20 kb

Low Sex Hormone-Binding Globulin Levels Associate with Prediabetes in Chinese Men Independent of Total Testosterone

<div><p>Objective</p><p>The association ns between prediabetes and androgens have been rarely reported, especially in Chinese men. We aimed to investigate whether androgens were associated with the prevalence of prediabetes diagnosed with new American Diabetes Association criteria in Chinese men and then to assess which androgen value was the most relevant factor.</p><p>Methods</p><p>A total of 2654 men (52.6±13.4 years old) were selected. Serum total testosterone (TT), sex hormone-binding globulin (SHBG) and free testosterone (FT) were measured. Covariance analysis of different androgen values were performed in age subgroups. Multinomial logistic regression was used for the association of TT, SHBG and FT with prediabetes and diabetes, as well as prediabetes in age subgroups.</p><p>Results</p><p>According to ADA new criteria, normoglycemia, prediabetes, and diabetes were diagnosed in 1405, 907 and 342 men, respectively. In covariance analysis, SHBG of prediabetes were found lower than that of normoglycemia but higher than that of diabetes (<i>P</i> <0.05). In multinomial logistic regression, serum TT and SHBG were inversely associated with prediabetes and diabetes. While, after full adjustment for age, residence area, economic status, waist circumference, metabolic factors, other two androgen values and HOMA-IR, only the associations of SHBG with prevalence of prediabetes and diabetes persisted statistically significant, especially in the elderly with prediabetes (all <i>P</i> for trend <0.05).</p><p>Conclusions</p><p>Serum androgen was inversely associated with prediabetes and diabetes in Chinese men. Low serum SHBG was the most relevant factor for prediabetes and diabetes. Whether it is an independent predictor for incident prediabetes in Chinese men needs further explorations.</p></div

Lead Exposure Induces Weight Gain in Adult Rats, Accompanied by DNA Hypermethylation

<div><p>Objective</p><p>Previous studies have revealed the association of lead (Pb) exposure with obesity. DNA methylation alteration has been suggested to be one of the regulatory mechanisms of obesity. We aimed to explore whether Pb exposure is related with weight gain and DNA methylation alteration.</p><p>Methods</p><p>Male adult 8 week Wistar rats were divided into 5 groups: the normal chow diet (NCD); the NCD+0.05%Pb; the NCD+0.15%Pb; the NCD+0.45%Pb and the high fat diet. Rats were exposed to different dosages of Pb through drinking water for 21 weeks. Body weight, fasted blood glucose level, fasted insulin level, homeostasis assessment of insulin resistance (HOMA-IR) index and lipid profile were detected. Intra-peritoneal glucose tolerance test (IPGTT) was constructed to evaluate the glucose tolerance. Lipid accumulation of liver was detected and liver DNA underwent whole genome bisulfite sequencing.</p><p>Results</p><p>The NCD+0.05%Pb group had significantly greater weight, HOMA-IR and triglycerides, and lower glucose intolerance than the NCD group (P <0.05). This group also showed hepatic lipid accumulation. These metabolic changes were not observed in the other two Pb dosage groups. Furthermore, DNA hypermethylation extended along pathways related to glucose and lipid metabolism in NCD+0.05%Pb group.</p><p>Conclusion</p><p>Pb exposure resulted in dose-specific weight gain in adult Wistar rats, accompanied by alteration of DNA methylation.</p></div

Additional file 3: Figure S2. of CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling

CD274 is inversely correlated to the overall survival of AML patients. (A) In silico analysis of the expression of CD274 in human AML samples from the curated databases (the HemaExplorer, http://servers.binf.ku.dk/hemaexplorer/ ). (B) In silico analysis of the relationship between CD274 expression level and overall survival in AML patients from the databases of Leukemia Gene Atlas (LGA) ( http://www.leukemia-gene-atlas.org/LGAtlas/ ). (*, p < 0.05). (PDF 176 kb

DNA methylation enrichment and specific genes with altered DNA methylation for NCD+0.05%Pb group compared to NCD group.

<p>(a) The top 10 KEGG pathways changed in NCD+0.05%Pb group compared to NCD group. <i>P</i> values were derived from Fisher’s Exact Test. (b) The heat map of specific genes related with glucose and lipid metabolism (FDR<0.25).</p

Bone Pb levels in rats (ng Pb/mg dry wt of femur) at 21 weeks.

<p>Bone Pb levels in rats (ng Pb/mg dry wt of femur) at 21 weeks.</p

Characteristics of the 2654 male subjects.

<p>Characteristics of the 2654 male subjects.</p

Analysis of covariance of TT, SHBG and FT among three groups with different glycemic status in age subgroups.

<p>Analysis of covariance of TT, SHBG and FT among three groups with different glycemic status in age subgroups.</p