29 research outputs found

    Association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status: evidence from a cluster randomized controlled trial

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    Purpose Evidence about the effect of maternal vitamin B12 supplementation on offspring’s vitamin B12 status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status. Methods In an ongoing cluster randomized controlled trial conducted in three rural counties in northwest China, pregnant women < 20 weeks of gestation were randomized to three treatment groups: blank control, iron supplements, or vitamin B complex supplements. All women were administered folic acid supplements during the periconceptional period. In a sub-study, we collected cord blood samples of 331 participants from the control or vitamin B complex groups in the Xunyi county from January 2017 to December 2017. Plasma concentrations of folate, vitamin B12, and homocysteine were measured. Linear mixed models with a random intercept for cluster were used to compare biochemical indexes between groups after controlling for covariates. Results Compared with newborns whose mothers were in the control group, newborns of the vitamin B complex-supplemented women had significantly higher cord plasma vitamin B12 (P = 0.001) and lower homocysteine concentrations (P = 0.043). The association of antenatal vitamin B complex supplementation with cord blood vitamin B12 concentrations appeared to be more pronounced among newborns with high folate status than those with low folate status (Pinteraction = 0.060). Conclusions Maternal vitamin B complex supplementation during pregnancy was associated with better neonatal vitamin B12 status in rural northwest China

    Maternal adherence to micronutrient supplementation before and during pregnancy in Northwest China: a large-scale population-based cross-sectional survey.

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    OBJECTIVES To report the situation of maternal micronutrient supplementation before and during pregnancy in Northwest China and to examine the rates of and factors related to the adherence to micronutrient supplementation among pregnant women in this region, where dietary micronutrient intake is commonly insufficient. DESIGN A large-scale population-based cross-sectional survey. SETTING Twenty counties and ten districts of Shaanxi Province. PARTICIPANTS A sample of 30 027 women were selected using a stratified multistage random sampling method. A total of 28 678 women were chosen for the final analysis after excluding those who did not provide clear information about nutritional supplementation before and during pregnancy. MAIN OUTCOME MEASURES Maternal adherence to micronutrient supplementation (high and low) were the outcomes. They were determined by the start time and duration of use according to Chinese guidelines (for folic acid (FA) supplements) and WHO recommendations (for iron, calcium and multiple-micronutrient (MMN) supplements). RESULTS In total, 83.9% of women took at least one kind of micronutrient supplement before or during pregnancy. FA (67.6%) and calcium (57.5%) were the primarily used micronutrient supplements; few participants used MMN (14.0%) or iron (5.4%). Adherence to supplementation of all micronutrients was low (7.4% for FA, 0.6% for iron, 11.7% for calcium and 2.7% for MMN). Higher educational levels, higher income levels, urban residence and better antenatal care (including pregnancy consultation and a higher frequency of antenatal visits) were associated with high adherence to micronutrient supplementation. CONCLUSION Maternal micronutrient supplementation before and during pregnancy in Northwest China was way below standards recommended by the Chinese guidelines or WHO. Targeted health education and future nutritional guidelines are suggested to improve this situation, especially in pregnant women with disadvantaged sociodemographic conditions

    Temporal-spatial characteristics and path analysis of maritime cyclones in Guangdong coastal areas in the South China Sea

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    This study was conducted to analyze the maritime cyclone characteristics in Guangdong coast in the years of 1949 to 2016, including inter-annual variation, the intensity of tropical cyclones, generating location and time, and path direction. The temporal-spatial characteristics were also studied. Results show there were 183 tropical cyclones landed in Guangdong coast in the past 68 years, with an average of 2.7 each year, which more than 60 percent were a typhoon. Most of the tropical cyclones were generated in the northwest Pacific, spanning from April to December. The path directions were mainly north, northwest, and west. The strengths of the tropical cyclones were reduced from central Guangdong coast to the east and the west sides, and the section of Zhanjiang city to Shenzhen city was the most vulnerable to tropical cyclones. Tropical cyclones that generated in the South China Sea tend to attack the west of the Guangdong coast, while the ones that produced in the northwest Pacific tend to attack the east of the Guangdong coast. In the study area, the tropical cyclones frequently occurred from July to September and became strongest in September. There are a most common landing section and path direction for each month. Finally, based on the statistical data and research results, the tropical cyclone paths in Guangdong coast were preliminarily analyzed

    Association between birth season and physical development in children under 3 years old residing in low-income counties in western China

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    <div><p>Objective</p><p>To explore the association between birth season and physical development and provide a necessary reference value to inform the implementation of public health services.</p><p>Design</p><p>Cross-sectional study.</p><p>Setting</p><p>Forty-five counties in ten provinces in western China in 2005.</p><p>Subjects</p><p>A sample of 13,387 children under 3 years old and their mothers were recruited using a stratified, multistage, cluster random sampling method.</p><p>Results</p><p>The results of the circular distribution analysis suggested that stunting and underweight exhibited time aggregation (Z = 32.57, P<0.05; Z = 10.42, P<0.05) among children under 3 years old. The <i>Z</i> − value for wasting, however, was not statistically significant (P>0.05). The generalized linear mixed models showed that children born in the summer were less likely to exhibit stunting (OR: 0.74~0.97) than were children born in the winter after adjusting for confounders, but no significant differences were identified for the other seasons. In addition, among children aged 25 to 36 months, those born in the summer and autumn were less likely to exhibit stunting after adjusting for confounders than were children born in the winter, but the association between birth in spring and stunting was not statistically significant.</p><p>Conclusions</p><p>Stunting was associated with season of birth among children under 3 years old in low-income counties in western China, especially children aged 25 to 36 months, and children born in the summer and autumn were less likely to exhibit stunting than were children born in the winter.</p></div
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