Neuroprotective Dihydroagarofuran Sesquiterpene Derivatives from the Leaves of <i>Tripterygium wilfordii</i>

Thirteen dihydroagarofuran derivatives, including 12 new sesquiterpenoid esters and one known sesquiterpenoid alkaloid, were obtained from the leaves of <i>Tripterygium wilfordii</i>. Spectroscopic techniques and the ECD method were used for the structure elucidation of the compounds. The structures of compounds <b>1</b> and <b>8</b> were confirmed by single-crystal X-ray crystallographic analyses. Compounds <b>8</b>, <b>9</b>, <b>11</b>, <b>12</b>, and <b>13</b> increased cell viability of the okadaic acid treated PC12 cells from 60.4 ± 23.0% to 72.4 ± 14.1, 71.5 ± 11.5, 75.7 ± 15.6, 81.2 ± 13.1, and 86.2 ± 25.5% at 10 μM, respectively

Neuroprotective Dihydroagarofuran Sesquiterpene Derivatives from the Leaves of <i>Tripterygium wilfordii</i>

Thirteen dihydroagarofuran derivatives, including 12 new sesquiterpenoid esters and one known sesquiterpenoid alkaloid, were obtained from the leaves of <i>Tripterygium wilfordii</i>. Spectroscopic techniques and the ECD method were used for the structure elucidation of the compounds. The structures of compounds <b>1</b> and <b>8</b> were confirmed by single-crystal X-ray crystallographic analyses. Compounds <b>8</b>, <b>9</b>, <b>11</b>, <b>12</b>, and <b>13</b> increased cell viability of the okadaic acid treated PC12 cells from 60.4 ± 23.0% to 72.4 ± 14.1, 71.5 ± 11.5, 75.7 ± 15.6, 81.2 ± 13.1, and 86.2 ± 25.5% at 10 μM, respectively

Neuroprotective Dihydroagarofuran Sesquiterpene Derivatives from the Leaves of <i>Tripterygium wilfordii</i>

Thirteen dihydroagarofuran derivatives, including 12 new sesquiterpenoid esters and one known sesquiterpenoid alkaloid, were obtained from the leaves of <i>Tripterygium wilfordii</i>. Spectroscopic techniques and the ECD method were used for the structure elucidation of the compounds. The structures of compounds <b>1</b> and <b>8</b> were confirmed by single-crystal X-ray crystallographic analyses. Compounds <b>8</b>, <b>9</b>, <b>11</b>, <b>12</b>, and <b>13</b> increased cell viability of the okadaic acid treated PC12 cells from 60.4 ± 23.0% to 72.4 ± 14.1, 71.5 ± 11.5, 75.7 ± 15.6, 81.2 ± 13.1, and 86.2 ± 25.5% at 10 μM, respectively

Nototronesides A–C, Three Triterpene Saponins with a 6/6/9 Fused Tricyclic Tetranordammarane Carbon Skeleton from the Leaves of <i>Panax notoginseng</i>

Three triterpene saponins, nototronesides A–C (<b>1</b>–<b>3</b>), possessing an unprecedented 6/6/9 fused tricyclic tetranordammarane core, were isolated from the leaves of <i>Panax notoginseng</i>. Their structures were elucidated on the basis of spectroscopic data, and the structure of sapogenin (<b>1a</b>) was further confirmed by X-ray crystallography. The existence of <b>1</b>–<b>3</b> adds a new dimension to the diversity of the triterpene family. Moreover, compound <b>2</b> showed a moderate neuroprotective effect on serum deficiency-induced cellular damage in PC12 cells

Hepatoprotective glycosides from the rhizomes of <i>Imperata cylindrical</i>

<p>Three new C-methylated phenylpropanoid glycosides (<b>1</b>, <b>2</b>), a new 8–4′-oxyneolignan (<b>3</b>), together with two known analogs (<b>4</b>, <b>5</b>), were isolated from the rhizomes of <i>Imperata cylindrical</i> Beauv. var. <i>major</i> (Nees) C. E. Hubb. Their structures were determined by spectroscopic and chemical methods. Compounds <b>1</b>, <b>2</b>, and <b>5</b> (10 μM) exhibited pronounced hepatoprotective activity against <i>N</i>-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage <i>in vitro</i> assays. Furthermore, their antioxidant activities against Fe²⁺-cysteine-induced rat liver microsomal lipid peroxidation and the effects on the secretion of TNF-α in murine peritoneal macrophages (RAW264.7) induced by lipopolysaccharides were evaluated.</p