4 research outputs found
Effect of Peptide Sequences on Supramolecular Interactions of Naphthaleneimide/Tripeptide Conjugates
In this study, we reported a significant
difference in the supramolecular
hydrogelation of newly discovered <b>NI-GFF</b> (NI-Gly-l-Phe-l-Phe) and <b>NI-FFG</b> (NI-l-Phe-l-Phe-Gly) on the basis of their phase diagrams. With
a small difference in the peptide chain between <b>NI-GFF</b> and <b>NI-FFG</b>, we observed a significant difference in
their self-assembly properties; <b>NI-GFF</b> formed a stable
gel at neutral pH, whereas <b>NI-FFG</b> did not, under the
same conditions. From spectroscopic and computational studies, intermolecular
π–π interactions and extended hydrogen bonding
interactions might reinforce the intermolecular interactions of <b>NI-GFF</b>, which may facilitate the formation of the self-assembled
nanostructures and the hydrogel. In addition, the aggregation-induced
emission (AIE)-active <b>NI-GFF</b> reveals relatively good
biocompatibility compared with that of <b>NI-FFG</b> for two
commonly used cell lines, suggesting that it is a promising candidate
for use as a supramolecular material in biomedical applications. Our
results highlight the importance of tripeptide sequences in a self-assembling
hydrogel system
Outcome of Population-based Spinal Muscular Atrophy (SMA) Screening in Taiwan.
<p>*Data available from the Bureau of Health Promotion, Department of Health, Taiwan (<a href="http://www.bhp.doh.gov.tw/BHPnet/Portal/" target="_blank">http://www.bhp.doh.gov.tw/BHPnet/Portal/</a>).</p
Genotypes of Couples at Risk for Offspring with Spinal Muscular Atrophy.
<p>Genotypes of Couples at Risk for Offspring with Spinal Muscular Atrophy.</p
Spinal Muscular Atrophy Genotype Distribution.
<p>Spinal Muscular Atrophy Genotype Distribution.</p