Effect of Peptide Sequences on Supramolecular Interactions of Naphthaleneimide/Tripeptide Conjugates

In this study, we reported a significant difference in the supramolecular hydrogelation of newly discovered <b>NI-GFF</b> (NI-Gly-l-Phe-l-Phe) and <b>NI-FFG</b> (NI-l-Phe-l-Phe-Gly) on the basis of their phase diagrams. With a small difference in the peptide chain between <b>NI-GFF</b> and <b>NI-FFG</b>, we observed a significant difference in their self-assembly properties; <b>NI-GFF</b> formed a stable gel at neutral pH, whereas <b>NI-FFG</b> did not, under the same conditions. From spectroscopic and computational studies, intermolecular π–π interactions and extended hydrogen bonding interactions might reinforce the intermolecular interactions of <b>NI-GFF</b>, which may facilitate the formation of the self-assembled nanostructures and the hydrogel. In addition, the aggregation-induced emission (AIE)-active <b>NI-GFF</b> reveals relatively good biocompatibility compared with that of <b>NI-FFG</b> for two commonly used cell lines, suggesting that it is a promising candidate for use as a supramolecular material in biomedical applications. Our results highlight the importance of tripeptide sequences in a self-assembling hydrogel system

Outcome of Population-based Spinal Muscular Atrophy (SMA) Screening in Taiwan.

<p>*Data available from the Bureau of Health Promotion, Department of Health, Taiwan (<a href="http://www.bhp.doh.gov.tw/BHPnet/Portal/" target="_blank">http://www.bhp.doh.gov.tw/BHPnet/Portal/</a>).</p

Genotypes of Couples at Risk for Offspring with Spinal Muscular Atrophy.

<p>Genotypes of Couples at Risk for Offspring with Spinal Muscular Atrophy.</p

Spinal Muscular Atrophy Genotype Distribution.

<p>Spinal Muscular Atrophy Genotype Distribution.</p