5 research outputs found
Palladium-Catalyzed Synthesis of α‑Iminonitriles from Aryl Halides via Isocyanide Double Insertion Reaction
An
efficient one-pot synthesis of α-iminonitriles from readily
available aryl halides via palladium-catalyzed double isocyanide insertion
and elimination has been developed, without using various hypertoxic
cyanides and excess oxidants. Furthermore, the utility of this reaction
was demonstrated by the rapid total synthesis of quinoxaline and the
reaction of functional groups exchanged with aryl halides
Palladium-Catalyzed Oxidative Three-Component Coupling of Anthranilamides with Isocyanides and Arylboronic Acids: Access to 2,3-Disubstituted Quinazolinones
A novel palladium-catalyzed oxidative
three-component coupling
of easily accessible <i>N</i>-substituted anthranilamides
with isocyanides and arylboronic acids is achieved. This protocol
offers an alternative approach toward 2,3-disubstituted quinazolinones
with a wide substrate scope and good functional group tolerance
Additional file 1 of Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2
Aditional file 1: Table S1. Primer sequences
Additional file 2 of Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2
Additional file 2: Figure S1. ILA promoted ISCs proliferation. (A) Ki67 mRNA levels in intestinal tissues (n = 4–5/group). (B) Lgr5 mRNA levels in intestinal tissues (n = 4–5/group). (C) Ascl2 mRNA levels in intestinal tissues (n = 4–5/group). Results are presented as mean ± SEM. * p < 0.05, ** p < 0.01
Cu-Mediated Stereoselective [4+2] Annulation between <i>N</i>‑Hydroxybenzimidoyl Cyanide and Norbornene
A Cu-mediated stereoselective [4+2]
annulation between <i>N</i>-hydroxybenzimidoyl cyanides
and norbornene (NBE) has been
developed for the synthesis of 4<i>H</i>-1,2-oxazin-4-ones.
The reaction proceeds through sequentially forming C–O/C–C
bonds. The advantage of this reaction includes high stereoselectivity,
excellent yields, as well as simple and mild reaction conditions.
A total of 26 examples are presented along with some control experiments