Palladium-Catalyzed Synthesis of α‑Iminonitriles from Aryl Halides via Isocyanide Double Insertion Reaction

An efficient one-pot synthesis of α-iminonitriles from readily available aryl halides via palladium-catalyzed double isocyanide insertion and elimination has been developed, without using various hypertoxic cyanides and excess oxidants. Furthermore, the utility of this reaction was demonstrated by the rapid total synthesis of quinoxaline and the reaction of functional groups exchanged with aryl halides

Palladium-Catalyzed Oxidative Three-Component Coupling of Anthranilamides with Isocyanides and Arylboronic Acids: Access to 2,3-Disubstituted Quinazolinones

A novel palladium-catalyzed oxidative three-component coupling of easily accessible <i>N</i>-substituted anthranilamides with isocyanides and arylboronic acids is achieved. This protocol offers an alternative approach toward 2,3-disubstituted quinazolinones with a wide substrate scope and good functional group tolerance

Additional file 1 of Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2

Aditional file 1: Table S1. Primer sequences

Additional file 2 of Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2

Additional file 2: Figure S1. ILA promoted ISCs proliferation. (A) Ki67 mRNA levels in intestinal tissues (n = 4–5/group). (B) Lgr5 mRNA levels in intestinal tissues (n = 4–5/group). (C) Ascl2 mRNA levels in intestinal tissues (n = 4–5/group). Results are presented as mean ± SEM. * p < 0.05, ** p < 0.01

Cu-Mediated Stereoselective [4+2] Annulation between <i>N</i>‑Hydroxybenzimidoyl Cyanide and Norbornene

A Cu-mediated stereoselective [4+2] annulation between <i>N</i>-hydroxybenzimidoyl cyanides and norbornene (NBE) has been developed for the synthesis of 4<i>H</i>-1,2-oxazin-4-ones. The reaction proceeds through sequentially forming C–O/C–C bonds. The advantage of this reaction includes high stereoselectivity, excellent yields, as well as simple and mild reaction conditions. A total of 26 examples are presented along with some control experiments