785 research outputs found

    Deep Drawing of Cylindrical Cup Using Incremental Electromagnetic Assisted Stamping with Radial Magnetic Pressure

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    AbstractA new forming method named incremental electromagnetic assisted stamping with radial magnetic pressure is proposed to draw a deep cylindrical cup. The method combines with traditional stamping, electromagnetic sheet forming and electromagnetic launch technology. Three types of discharge coils are imbedded in die and blank holder, respectively. The 3D finite element model is set up to predict the complex deformation process. The forming process and principle of the new method are discussed. The values of material flow, stress and thickness in different forming processes are compared. In comparison with traditional stamping, incremental electromagnetic assisted stamping with radial magnetic pressure can significantly increase the value of material at sheet end flow inward, decrease the tensile stress and thickness reduction at the easily broken position, and obtain uniform stress distribution. Therefore, deeper cylindrical cup could be manufactured by incremental electromagnetic assisted stamping with radial magnetic pressure

    Domain-Agnostic Molecular Generation with Self-feedback

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    The generation of molecules with desired properties has gained tremendous popularity, revolutionizing the way scientists design molecular structures and providing valuable support for chemical and drug design. However, despite the potential of language models in molecule generation, they face numerous challenges such as the generation of syntactically or chemically flawed molecules, narrow domain focus, and limitations in creating diverse and directionally feasible molecules due to a dearth of annotated data or external molecular databases. To this end, we introduce MolGen, a pre-trained molecular language model tailored specifically for molecule generation. MolGen acquires intrinsic structural and grammatical insights by reconstructing over 100 million molecular SELFIES, while facilitating knowledge transfer between different domains through domain-agnostic molecular prefix tuning. Moreover, we present a self-feedback paradigm that inspires the pre-trained model to align with the ultimate goal of producing molecules with desirable properties. Extensive experiments on well-known benchmarks confirm MolGen's optimization capabilities, encompassing penalized logP, QED, and molecular docking properties. Further analysis shows that MolGen can accurately capture molecule distributions, implicitly learn their structural characteristics, and efficiently explore chemical space. The pre-trained model, codes, and datasets are publicly available for future research at https://github.com/zjunlp/MolGen.Comment: Work in progress. Add results of binding affinit

    De novo transcriptome analysis of the sandworm (Sipunculus nudus) and identification of differentially expressed genes associated with body size

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    The sandworm (Sipunculus nudus) is an aquatic species of economic importance because of its high nutritional and medicinal value. Under the same culture conditions, substantial individual growth variation is often found in populations of sandworms. However, the genetic mechanisms of individual growth variation are poorly understood. In this study, the transcriptome of the body wall muscle of the sandworm at different growth rates was analyzed by Illumina sequencing and bioinformatics analysis. A total of 185 181 unigenes were obtained after processing raw reads and about 96,824 (47.72%) of them were annotated. Among the annotated transcripts, 418 differentially expressed genes were identified, of which 207 were upregulated and 211 were downregulated in large worms relative to small worms. We identified several genes that had a possible association with individual growth variation. These results will provide insight into the growth mechanism of sandworm, and will further assist in the selective breeding of improved strains of this species

    Expatriates, subsidiary autonomy and the overseas subsidiary performance of MNEs from an emerging economy

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    Despite a growing body of research on the role of expatriates in subsidiary performance, the mechanisms through which expatriates affect subsidiary performance are still the subject of debate. Drawing on the resource dependence theory, we examine the indirect effect of expatriates on subsidiary performance via subsidiary autonomy based on a sample of Chinese multinational enterprises (MNEs). The findings show that an increase in expatriates reduces the level of subsidiary autonomy and thus negatively affects subsidiary performance. We also find that the institutional quality of host countries reinforces the negative impact of expatriates on subsidiary autonomy, but reduces the importance of the latter on subsidiary performance

    Do cross-border mergers and acquisitions increase short-term market performance? The case of Chinese firms

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    Despite the new momentum in cross-border mergers and acquisitions (M&As) by emerging market firms, we have a limited understanding of the impact of these activities. Drawing on signalling theory and the institution-based view, this paper examines the extent of stock market reactions to the announcement of cross-border M&A deals, based on an event study of a sample of Chinese firms during the period 2000– 2012. The findings indicate that the announcement of cross-border M&As results in a positive stock market reaction; this effect is more significant in the mainland Chinese stock markets (Shanghai and Shenzhen) than that in the Hong Kong market. The shareholders of Chinese firms that acquire a target firm in a host country with a low level of political risk gain higher cumulative abnormal returns than those firms targeting companies in countries with a high level of political risk. The shareholders of Chinese state-owned enterprises experience lower abnormal returns compared with those of Chinese privately owned firms when engaging in cross-border M&A deals
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