344 research outputs found
Pattern formation for reactive species undergoing anisotropic diffusion
Turing instabilities for a two species reaction-diffusion systems is studied
under anisotropic diffusion. More specifically, the diffusion constants which
characterize the ability of the species to relocate in space are direction
sensitive. Under this working hypothesis, the conditions for the onset of the
instability are mathematically derived and numerically validated. Patterns
which closely resemble those obtained in the classical context of isotropic
diffusion, develop when the usual Turing condition is violated, along one of
the two accessible directions of migration. Remarkably, the instability can
also set in when the activator diffuses faster than the inhibitor, along the
direction for which the usual Turing conditions are not matched
Turing patterns in multiplex networks
The theory of patterns formation for a reaction-diffusion system defined on a
multiplex is developed by means of a perturbative approach. The intra-layer
diffusion constants act as small parameter in the expansion and the unperturbed
state coincides with the limiting setting where the multiplex layers are
decoupled. The interaction between adjacent layers can seed the instability of
an homogeneous fixed point, yielding self-organized patterns which are instead
impeded in the limit of decoupled layers. Patterns on individual layers can
also fade away due to cross-talking between layers. Analytical results are
compared to direct simulations
Photoproduction of axion-like particles
We explore the sensitivity of photon-beam experiments to axion-like particles
(ALPs) with QCD-scale masses whose dominant coupling to the Standard Model is
either to photons or gluons. We introduce a novel data-driven method that
eliminates the need for knowledge of nuclear form factors or the photon-beam
flux when considering coherent Primakoff production off a nuclear target, and
show that data collected by the PrimEx experiment could substantially improve
the sensitivity to ALPs with GeV. Furthermore,
we explore the potential sensitivity of running the GlueX experiment with a
nuclear target and its planned PrimEx-like calorimeter. For the case where the
dominant coupling is to gluons, we study photoproduction for the first time,
and predict the future sensitivity of the GlueX experiment using its nominal
proton target. Finally, we set world-leading limits for both the ALP-gluon
coupling and the ALP-photon coupling based on public mass plots.Comment: 17 pages, 7 figures; v3 corrected PrimEx results for luminosity
error; v2 added missing factor when drawing the GlueX limits on the ALP-gluon
coupling, fixed convention discrepancy in the SeaQuest ALP-photon limits,
other minor edit
Video monitoring of Sparidae temporal rhythms: three-year study by OBSEA cabled observatory
The abundance and composition of fish assemblages varies at different temporal scales as a product of diel and annual rhythms. In this study, we used a video-wired observatory (OBSEA, www.obsea.es) to monitor annual rhythms in a coastal fish assemblage with a 3-year data set (2012-2014). The photographs were acquired at 30 min frequency. Five species of the family Sparidae were studied (i.e. Dentex dentex, Diplodus sargus, Diplodus vulgaris, Diplodus annularis and Diplodus puntazzo) together with water temperature and daylength. The results of the annual rhythmicity analysis indicated that most of the peaks of abundance occured in the autumn months. Results suggest differentially temporal use of the reproductive or trophic niche.Peer ReviewedPostprint (published version
Homogeneous-per-layer patterns in multiplex networks
A new class of patterns for multiplex networks is studied, which consists in a collection of different homogeneous states each referred to a distinct layer. The associated stability diagram exhibits a tricritical point, as a function of the inter-layer diffusion coefficients. The patterns, made of alternating homogeneous layers of networks, are dynamically selected via non-homogeneous perturbations superposed to the underlying, globally homogeneous, fixed point and by properly modulating the coupling strength between layers. Furthermore, layer-homogeneous fixed points can turn unstable following a mechanism à la Turing, instigated by the intra-layer diffusion. This novel class of solutions enriches the spectrum of dynamical phenomena as displayed within the variegated realm of multiplex science
The involvement of heat shock proteins and related molecules in the resistance to therapies in breast and gynecologic cancer
The HSP response is implicated in conferring to breast and gynecologic malignancies different sensitivities to anticancer therapies including chemotherapy, endocrine therapy and immunotherapy (weare in the need of more studies about radiotherapy). The heat shock proteins are mainly implicated in cell death mechanisms, in cell differentiation including epithelial-mesenchymal transition, in tumordormancy, in angiogenesis, metastasis formation, and in the escape of immunosurveillance. Considering the ample functions where the HSPs are implicated and that the HSP response is quite complex it is not surprising that the HSP response affects the anticancer therapies. Several of the HSPs have different predominant roles according to the molecular partners with which they interact, thus it is difficult to dissect the molecular mechanisms to find the sensitivity to the therapies. In this review we present the implications of some the major HSPs (HSP27, HSP70 and HSP90) with drug resistance and present some of the main partners that are also implicated in drug resistance like p53, PTEN and MDR. We have given priority to the incorporation of clinical data where the HSPs have been studied using standard chemotherapies and new therapeutic strategies. It is clear that in order to have a significant understanding of the degree of drug resistance/sensitivity presented by a particular patient we need to examine the molecular status of several key molecular markers involved in the drug resistance pathways and that in this context the study of the HSP response should be incorporated. One of the other major problems in this field is that an inhibitor of one particular HSP will not be enough to achieve a significant anticancer response. Now that we know the complexity of this field we need to design strategies aiming to inhibit several molecular HSP pathways simultaneously without significantly affecting the normal cells, this is the principal challenge for the near future.Fil: Cuello Carrión, Fernando Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Castro, Gisela Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Cayado Gutiérrez, Niubys de Los Milagros. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentin
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