Safety limitations of MR-HIFU treatment near interfaces : a phantom validation

Peer reviewe

Cross-Cultural Art from the Perspective of Aesthetic Education: Cultural Exchange in Chinese Export Paintings (18th - 19th Century)

During the late Ming to early Qing dynasties, the great demand for Chinese export porcelain laid the foundation for the development of export paintings. From the 18th to the 19th century, a unique form of cultural hybridity emerged in the coastal area of Canton: export paintings. This paper attempts to explore the interaction, conflict, and fusion with foreign cultures within the frameworks of Homi Bhabha's "third space" theory and Mary Louise Pratt's concept of the "contact zone." It examines how this cross-cultural art form manifests hybridity in materials, painting techniques, and themes.From the perspective of aesthetic education, these paintings provide profound insights into the cultivation of aesthetic sensibilities and cross-cultural appreciation. Predominantly produced by Chinese painters and workshops, with a few contributions from visiting European painters, these artworks cover a broad range of subjects, including Chinese social life, flora and fauna, and folk customs. By examining the aesthetic value and educational potential of these works through the lens of aesthetic education, we can better understand their significance in cross-cultural art exchange. This cross-cultural art form not only holds aesthetic importance but also provides a new perspective for studying Sino-Western cultural interactions, enriching the discourse on art education and cultural exchange

Luxury Embodied and Artistic Exchange: Japanese Lacquer in the Dutch Golden Age

This paper conducts an in-depth exploration of the luxury concept encapsulated within Japanese lacquer during the Dutch Golden Age and its profound implications in cross-cultural exchanges. Through a detailed analysis of the trade history, wherein the Dutch East India Company (VOC) played a pivotal role in introducing Japanese lacquer to the Netherlands, its appearances in paintings that influenced Dutch art, and the emergence of imitations due to its high value, the multi-faceted nature of Japanese lacquer as a luxury item is revealed. In the 17th century, the advanced nautical technology of the Netherlands enabled global trade, and Japanese lacquer, with its exquisite craftsmanship and rarity, became a symbol of wealth and status. The VOC dominated the trade, providing customized lacquer for the aristocracy and using it in diplomatic exchanges. In paintings, its diverse styles led to cultural fusion and artistic innovation. The high price led to Dutch imitations, attesting to its luxury status. Overall, Japanese lacquer was a key luxury symbol, impacting Dutch society, art, and promoting cultural exchange, offering valuable insights into 17th-century Europe-Asia cultural interactions

The Role of CD 133+ Cells in a Recurrent Embryonal Tumor with Abundant Neuropil and True Rosettes ( ETANTR )

Embryonal tumor with abundant neuropil and true rosettes ( ETANTR ) is a recently described embryonal neoplasm of the central nervous system, consisting of a well‐circumscribed embryonal tumor of infancy with mixed features of ependymoblastoma (multilayer ependymoblastic rosettes and pseudorosettes) and neuroblastoma (neuroblastic rosettes) in the presence of neuropil‐like islands. We present the case of a young child with a very aggressive tumor that rapidly recurred after gross total resection, chemotherapy and radiation. Prominent vascular sclerosis and circumscribed tumor led to the diagnosis of malignant astroblastoma; however, rapid recurrence and progression of this large tumor after gross total resection prompted review of the original pathology. ETANTR is histologically distinct with focal glial fibrillary acid protein ( GFAP ) and synaptophysin expression in the presence of neuronal and ependymoblastic rosettes with focal neuropil islands. These architectural features, combined with unique chromosome 19q13.42 amplification, confirmed the diagnosis. In this report, we describe tumor stem cell ( TSC ) marker CD 133, CD 15 and nestin alterations in ETANTR before and after chemotherapy. We found that TSC marker CD 133 was richly expressed after chemotherapy in recurrent ETANTR , while CD 15 is depleted compared with that expressed in the original tumor, suggesting that CD 133+ cells likely survived initial treatment, further contributing to formation of the recurrent tumor.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102077/1/bpa12079.pd

Targeting Histone Reader ENL with PROTAC Degrader

ENL is a histone reader that is part of the super elongation complex and is primarily involved in chromatin and gene expression regulation. ENL has also been found to play an essential role in the progression of a spectrum of acute myeloid leukemia (AML). Some hotspot mutations of its reader module, the YEATS domain, have been found to be oncogenic. For this reason, we explored the efficacy of a newly developed ENL PROTAC degrader in its ability to degrade wild-type and mutant ENL protein and suppress oncogene expression in cancer cells

catena-Poly[[aqua­(3-methyl­benzoato-κ2 O,O′)lead(II)]-μ-3-methyl­benzoato-κ4 O:O,O′:O′]

The reaction of lead(II) acetate and 3-methyl­benzoic acid (MBA) in aqueous solution yielded the title polymer, [Pb(C8H7O2)2(H2O)]n. The asymmetric unit contains two PbII atoms, four MBA ligands and two water mol­ecules. Each PbII cation is hepta­coordinated and chelated by four carboxyl­ate O atoms from two MBA ligands. The Pb atoms are bridged through the carboxyl­ate O atoms from another two MBA ligands, leading to a central Pb2O2 core. The Pb—O bond lengths are in the range 2.325 (3)–2.757 (4) Å. The intra- and inter­dimer Pb⋯Pb distances are 4.2942 (3) and 4.2283 (3) Å, respectively, indicating little direct metal–metal inter­action. The coordinating water mol­ecules and carboxyl­ate O atoms are involved in extensive O—H⋯O hydrogen-bonding inter­actions. The complex has an extended ladder-like chain structure and the chains are assembled by hydrogen bonds and π–π inter­actions [centroid–centroid distance = 3.6246 (3) Å] into a three-dimensional supra­molecular structure

Introduction to matrix-based method for analyzing hybrid multidimensional prostate MRI data

A new approach to analysis of prostate hybrid multidimensional MRI (HM-MRI) data was introduced in this study. HM-MRI data were acquired for a combination of a few echo times (TEs) and a few b-values. Naturally, there is a matrix associated with HM-MRI data for each image pixel. To process the data, we first linearized HM-MRI data by taking the natural logarithm of the imaging signal intensity. Subsequently, a hybrid symmetric matrix was constructed by multiplying the matrix for each pixel by its own transpose. The eigenvalues for each pixel could then be calculated from the hybrid symmetric matrix. In order to compare eigenvalues between patients, three b-values and three TEs were used, because this was smallest number of b-values and TEs among all patients. The results of eigenvalues were displayed as qualitative color maps for easier visualization. For quantitative analysis, the ratio (λr) of eigenvalues (λ1, λ2, λ3) was defined as λr = (λ1/λ2)/λ3 to compare region of interest (ROI) between prostate cancer (PCa) and normal tissue. The results show that the combined eigenvalue maps show PCas clearly and these maps are quite different from apparent diffusion coefficient (ADC) and T2 maps of the same prostate. The PCa has significant larger λr, smaller ADC and smaller T2 values than normal prostate tissue (p < 0.001). This suggests that the matrix-based method for analyzing HM-MRI data provides new information that may be clinically useful. The method is easy to use and could be easily implemented in clinical practice. The eigenvalues are associated with combination of ADC and T2 values, and could aid in the identification and staging of PCa

Surface Coating of Cyclotetramethylenetetranitramine (HMX) Particles and Its Property Investigation

To improve the safety of cyclotetramethylenetetranitramine (HMX) particles, the polymer thermoplastic polyurethane elastomer (TPU) and nitrocellulose (NC) were introduced to coat HMX powder by water-solution suspension method and internal solution method, respectively. Scanning electron microscope (SEM) and X-ray photo-electron spectrometry (XPS) were employed to characterize the HMX samples and the role of NC and TPU in the coating processes were discussed. The impact sensitivity, friction sensitivity, and the thermal decomposition of coated HMX particles were investigated, and compared to the unprocessed ones. The results indicate that both TPU and NC can improve the wetting ability of the coating materials on HMX surface and reinforce the connection between HMX and the coating materials. The impact sensitivity and friction sensitivity of HMX samples decrease obviously after they have been surface coated; the drop height (H50) is increased from 35.24 cm to 50.08 cm, and the friction probability is reduced from 93.2 % to 58.3%. The activation energy (Ea) and the self-ignition temperature increase by 10.46 KJ·mol-1 and 1.8, respectively