Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges

Research on molecular targeted therapy of tumors is booming, and novel targeted therapy drugs are constantly emerging. Small molecule targeted compounds, novel targeted therapy drugs, can be administered orally as tablets among other methods, and do not draw upon genes, causing no immune response. It is easily structurally modified to make it more applicable to clinical needs, and convenient to promote due to low cost. It refers to a hotspot in the research of tumor molecular targeted therapy. In the present study, we review the current Food and Drug Administration (FDA)-approved use of small molecule targeted compounds in tumors, summarize the clinical drug resistance problems and mechanisms facing the use of small molecule targeted compounds, and predict the future directions of the evolving field

Development and Experimental Study of Mobile Fire Smoke Decontamination System

Fire smoke decontamination equipment, such as fire-fighting robots and smoke exhaust robots, is mainly used in long and narrow spaces such as underground garages. In several recent decades, the study of fire smoke spread in narrow spaces and fire smoke decontamination equipment stimulated the interests of many researchers. However, present equipment cannot eliminate insoluble toxic gases such as CO and may decrease the height of the smoke layer, causing great difficulty to rescue. In this study, a novel mobile fire smoke decontamination process and system are proposed. The experimental study and theoretical prediction of the system are conducted. The results show that the developed equipment is able to eliminate fire smoke particles and CO, cool the space, and improve the visibility of the fire site. The developed equipment can reduce the space temperature to below 60 °C, reduce the CO concentration to below 145 ppm, and enhance the visibility to more than 50 m in the rectangular tunnel after operating for 30 min under 4 MW fire condition

Development and Experimental Study of Mobile Fire Smoke Decontamination System

Fire smoke decontamination equipment, such as fire-fighting robots and smoke exhaust robots, is mainly used in long and narrow spaces such as underground garages. In several recent decades, the study of fire smoke spread in narrow spaces and fire smoke decontamination equipment stimulated the interests of many researchers. However, present equipment cannot eliminate insoluble toxic gases such as CO and may decrease the height of the smoke layer, causing great difficulty to rescue. In this study, a novel mobile fire smoke decontamination process and system are proposed. The experimental study and theoretical prediction of the system are conducted. The results show that the developed equipment is able to eliminate fire smoke particles and CO, cool the space, and improve the visibility of the fire site. The developed equipment can reduce the space temperature to below 60 °C, reduce the CO concentration to below 145 ppm, and enhance the visibility to more than 50 m in the rectangular tunnel after operating for 30 min under 4 MW fire condition

Validation study on a non-linear dynamical model of the projectile

Abstract Based on the theoretical approach of multi-body interaction dynamics, a theoretical model is constructed to simulate the nonlinear response amplification of the projectile structure. The accuracy and universality of the theoretical model were verified by comparing the response data calculated by the theoretical model with the experimental data. The results show that the theoretical model can predict the acceleration and strain response of the projectile structure more accurately, providing a non-linear dynamic analysis method for the projectile structure from the perspective of structural dynamics

Research of the effect of compactness of fireproof mud plugging and proportion of backing material on fireproof performance

Building fire sealing technology is of great importance in preventing the spread of fire in buildings and reducing the damage caused by fire accidents. In order to investigate the influence of compactness, thickness and proportion of backing material on the fireproof performance of fireproof plugging material, this paper carries out experimental analysis on the pyrolysis process of fireproof plugging material to obtain the relevant parameters, and adopts a small-size fireproof mud-blocking combustion experimental platform to carry out combustion experiments. The experimental results prove that: with the increase of compactness, the thermal insulation and fireproofing performance of fireproof plugging material are enhanced; when the backing material is glass wool, the thermal insulation and fireproofing performance decreases with the increase of the proportion of glass wool; the expansion of fireproof plugging material caused by fire causes the hysteresis phase of thermal response in part of the cross section, and the time period of the hysteresis phase is delayed with the increase of compaction of fireproofing mud, and delayed with the decrease of the proportion of the thickness of backing material. The hysteresis phase is delayed with increasing compactness of fireproof plugging material and decreasing thickness of the backing material. The results of this paper can provide theoretical assistance for the expansion of fireproof plugging material by fire and for the process of installation

miRNA-31-5p Mediates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells via Targeting JAZF1 and Cyclin A2

Several lines of evidence highlight the important application of human spermatogonial stem cells (SSCs) in translational medicine. The fate decisions of SSCs are mainly mediated by genetic and epigenetic factors. We have recently demonstrated that PAK1 regulates the proliferation, DNA synthesis, and early apoptosis of human SSCs through the PDK1/KDR/ZNF367 and ERK1/2 and AKT pathway. However, the underlying epigenetic mechanism of PAK1 in human SSCs remains unknown. In this study, we found that the level of miRNA-31-5p was elevated by PAK1 knockdown. CCK-8, PCNA, and 5-ethynyl-2′-deoxyuridine (EDU) assays revealed that miRNA-31-5p mimics inhibited cell proliferation and DNA synthesis of human SSCs. Annexin V/propidium iodide (PI) staining and flow cytometry showed that miRNA-31-5p increased the early and late apoptosis of human SSCs. Furthermore, JAZF1 was predicted and verified as a target of miRNA-31-5p, and the three-dimensional (3D) structure model of JAZF1 protein was illustrated. JAZF1 silencing led to a reduction of cell proliferation and DNA synthesis as well as an enhancement of the early and late apoptosis of human SSCs. Finally, miRNA-31-5p mimics decreased the level of cyclin A2 rather than cyclin D1 or cyclin E1, and JAZF1 knockdown led to the reduction of cyclin A2 in human SSCs. Collectively, miRNA-31-5p regulates the proliferation, DNA synthesis, and apoptosis of human SSCs by the PAK1-JAZF1-cyclin A2 pathway. This study thus offers a novel insight into the molecular mechanisms underlying the fate determinations of human SSCs and might provide novel targets for molecular therapy of male infertility. Keywords: miRNA-31-5p, human spermatogonial stem cells, proliferation, apoptosis, JAZF1, cyclin A

Scalable Synthesis of Defect Abundant Si Nanorods for High-Performance Li-Ion Battery Anodes

Microsized nanostructured silicon–carbon composite is a promising anode material for high energy Li-ion batteries. However, large-scale synthesis of high-performance nano-Si materials at a low cost still remains a significant challenge. We report a scalable low cost method to synthesize Al/Na-doped and defect-abundant Si nanorods that have excellent electrochemical performance with high first-cycle Coulombic efficiency (90%). The unique Si nanorods are synthesized by acid etching the refined and rapidly solidified eutectic Al–Si ingot. To maintain the high electronic conductivity, a thin layer of carbon is then coated on the Si nanorods by carbonization of self-polymerized polydopamine (PDA) at 800 °C. The carbon coated Si nanorods (Si@C) electrode at 0.9 mg cm^–2 loading (corresponding to area-specific-capacity of ∼2.0 mAh cm^–2) exhibits a reversible capacity of ∼2200 mAh g^–1 at 100 mA g^–1 current, and maintains ∼700 mAh g^–1 over 1000 cycles at 1000 mA g^–1 with a capacity decay rate of 0.02% per cycle. High Coulombic efficiencies of 87% in the first cycle and ∼99.7% after 5 cycles are achieved due to the formation of an artificial Al₂O₃ solid electrolyte interphase (SEI) on the Si surface, and the low surface area (31 m² g^–1), which has never been reported before for nano-Si anodes. The excellent electrochemical performance results from the massive defects (twins, stacking faults, dislocations) and Al/Na doping in Si nanorods induced by rapid solidification and Na salt modifications; this greatly enhances the robustness of Si from the volume changes and alleviates the mechanical stress/strain of the Si nanorods during the lithium insertion/extraction process. Introducing massive defects and Al/Na doping in eutectic Si nanorods for Li-ion battery anodes is unexplored territory. We venture this uncharted territory to commercialize this nanostructured Si anode for the next generation of Li-ion batteries

Effects of bulking material types on water consumption and pollutant degradation in composting process with controlled addition of different liquid manures

This study was conducted to examine the effects of different bulking materials (corncob and ricehusk) on liquid manure consumption, organic matter degradation and pollutants retention in composting process under controlled addition of different types of liquid manures (LM). The results indicated that under the controlled addition of LM, bulking materials with higher content of biodegradable carbon (corncob) and LM with a higher concentration of organic pollutants (swine effluent) were more beneficial for biological heat generation and thus were more efficient for water evaporation, organic matter degradation, LM consumption and pollutants retention during the cocomposting process. Consequently, the optimization of these major influencing factors could compensate for efforts geared towards better utilization of the cocomposting process.This research has received funding from the STS project from Science and Technology Department in Fujian [2016T3006], Key Research and Development Program Social Development Project in Zhejiang [2015C03009], Science and Technology Planning Project of Fujian Province [2019T3023]