14 research outputs found
A blaVIM-2 Plasmid Disseminating in Extensively Drug-Resistant Clinical Pseudomonas aeruginosa and Serratia marcescens Isolates
Infections caused by carbapenem-resistant Enterobacteriaceae isolates are an issue of major global concern (1). Genes coding for metallo-β-lactamases (MβLs) identified in clinical isolates are associated with mobile elements and subject to horizontal genetic transfer (HGT) events (2–6). VIM-2 is present on numerous plasmids, but only pNOR-2000 from Pseudomonas aeruginosa COL-1 from France (7, 8) and pLD209 from Pseudomonas putida LD209 from Argentina (9) have been completely sequenced. Here, we report the complete sequence and characterization of plasmid pDCPR1 harboring a blaVIM-2 gene cassette in a Tn402-type class 1 integron, which was isolated from two extensively drug-resistant strains: P. aeruginosa 802 (from a burn patient at the Hospital Municipal de Quemados, Argentina, 2005) and S. marcescens 68313 (Sanatorio Sagrado CorazĂłn, Argentina, 2012).Fil: Vilacoba, Elisabet. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica; ArgentinaFil: Quiroga, Cecilia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica; ArgentinaFil: Pistorio, Mariano. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de BiotecnologĂa y BiologĂa Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de BiotecnologĂa y BiologĂa Molecular; ArgentinaFil: Famiglietti, Angela MarĂa Rosa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Rodriguez, Hernan Bernardo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Kovensky, Jaime. Ciudad AutĂłnoma de Buenos Aires. Hospital Municipal de Quemados; ArgentinaFil: Deraspe, Maxime. UniversitĂ© du QuĂ©bec a Montreal; Canadá. Laval University; CanadáFil: Raymond, FrĂ©dĂ©ric. UniversitĂ© du QuĂ©bec a Montreal; Canadá. Laval University; CanadáFil: Roy, Paul H.. UniversitĂ© du QuĂ©bec a Montreal; Canadá. Laval University; CanadáFil: Centron, Daniela. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica; Argentin
Evaluation of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry for species identification of Nonfermenting Gram-Negative Bacilli
Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) to identify 396 Nonfermenting Gram-Negative Bacilli clinical isolates was evaluated in comparison with conventional phenotypic tests and/or molecular methods. MALDI-TOF MS identified to species level 256 isolates and to genus or complex level 112 isolates. It identified 29 genera including uncommon species.Fil: Almuzara, Marisa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Barberis, Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Traglia, German Matias. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica; ArgentinaFil: Famiglietti, Angela MarĂa Rosa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Ramirez, Maria Soledad. California State University; Estados Unidos. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Vay, Carlos Alberto. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; Argentin
Clinical, Microbiological, and Genetic Characteristics of Heteroresistant Vancomycin-Intermediate Staphylococcus aureus Bacteremia in a Teaching Hospital
The emergence of vancomycin intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) is of major concern worldwide. Our objective was to investigate the prevalence, phenotypic and molecular features of hVISA strains isolated from bacteremic patients and to determine the clinical significance of the hVISA phenotype in patients with bacteremia. A total of 104 S. aureus blood isolates were collected from a teaching hospital of Argentina between August 2009 and November 2010. No VISA isolate was recovered, and 3 out of 92 patients (3.3%) were infected with hVISA, 2 of them methicillin-resistant S. aureus (MRSA) (4.5% of MRSA). Macro Etest and prediffusion method detected 3/3 and 2/3 hVISA respectively. Considering the type of bacteremia, the three cases were distributed as follows: two patients had suffered multiple episodes of bacteremia (both hVISA strains recovered in the second episode), while only one patient had suffered a single episode of bacteremia with hVISA infection. MRSA bloodstream isolates exhibiting the hVISA phenotype were related to HA-MRSA Cordobes clone (ST5-SCCmec I-spa t149) and MRSA Argentinean pediatric clone (ST100-SCCmec IVNV-spa t002), but not to CA-MRSA-ST30-SCCmec IV-spa t019 clone that was one of the most frequent in our country. Although still relatively infrequent in our hospital, hVISA strains weresignificantly associated with multiple episodes of bacteremia ( p = 0.037) and genetically unrelated.Fil: Di Gregorio, Sabrina Noelia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Perazzi, Beatriz Elizabeth. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Martinez Ordoñez, Andrea. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: de Gregorio, Stella. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Focoli, MĂłnica. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Lasala, MarĂa Beatriz. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Garcia, Susana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Vay, Carlos Alberto. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Famiglietti, Angela MarĂa Rosa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentin
Isolation of Bordetella Species from Unusual Infection Sites
Introduction: Bordetella hinzii has been isolated mainly from respiratory specimens and fromblood of immunocompromised patients, and Bordetella trematum from ear infections or leg, armand ankle wounds and from diabetic foot ulcers. Bordetella holmesii is instead associated withbactaeremia in young adults, mostly with underlying conditions. Only three septic arthritis casesdue to this species have been described in the literature.Case presentation: Herein we describe four cases of infections due to Bordetella species thathave been recovered from unusual infection sites: two cases of B. hinzii infections, one recoveredfrom the urine of a patient with chronic prostatitis and the other from a liver cyst in animmunocompetent patient; one B. trematum case from a bone biopsy of a patient with chronicosteomyelitis of the hip; and one B. holmesii case isolated from the joint fluid of animmunocompetent patient with diagnosed septic arthritis.The organisms were identified usingstandard biochemical tests, by API 20 NE version 6.0, by automated system VITEK 2, by massspectrometry using the Bruker Daltonics MicroFlex LT spectrometer with MALDI Biotyper 3.1,and by PCR amplification of 16S rRNA.Antibiotic susceptibility testing was performed using the VITEK 2 system, except for B. holmesii,for which the epsilometric method (Etest technique; bioMe´rieux) was used.Conclusion: We highlight the importance of isolating Bordetella species from severe infectionsand unusual sites, and also of combining both phenotypic and genotypic methods for definitiveidentification.Fil: Almuzara, Marisa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva PerĂłn"; ArgentinaFil: Barberis, Claudia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Traglia, German Matias. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica; ArgentinaFil: Sly, Gabriela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva PerĂłn"; ArgentinaFil: Procopio, Adriana. Gobierno de la Ciudad AutĂłnoma de Buenos Aires. Hospital General de Niños "Ricardo GutiĂ©rrez". Departamento de Medicina; ArgentinaFil: Vilches, Viviana. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Ramirez, Maria Soledad. California State University; Estados Unidos. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica; ArgentinaFil: Famiglietti, Angela MarĂa Rosa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Vay, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; Argentin
Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America
Klebsiella pneumoniae is one of the so-called ESKAPE pathogens. These organisms are the main cause of nosocomial infections worldwide, causing life-threatening infections amongst critically ill and immunocompromised individuals. They are characterized by drug resistance mechanisms. Klebsiella pneumoniae carbapenemase (KPC)-producing isolates display resistance to multiple antimicrobial agents, usually including last-resort alternative options, leading to an urgent need to develop new drugs or combinations. In Argentina sequence type (ST) 258 harbouring bla KPC-2 emerged in 2010 and remained prevalent until the last few years, when the emergence of different STs such as ST25, ST11 and ST307 appeared likely to change the local epidemiology.Fil: GarcĂa, J.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Cejas, Daniela. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Investigaciones En Bacteriologia y Virologia Molecular; ArgentinaFil: Santana, G.. No especifĂca;Fil: Mancino, M.B.. No especifĂca;Fil: Hidalgo, M.. No especifĂca;Fil: Maccallini, G.. No especifĂca;Fil: Vay, C.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Investigaciones En Bacteriologia y Virologia Molecular; ArgentinaFil: Dabos, L.. UniversitĂ© Paris Sud; FranciaFil: Famiglietti, Angela MarĂa Rosa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: RodrĂguez, H.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; Argentin
Vibrio vulnificus infection of the skin and soft parts: Communication of a case diagnosed in Argentina
Vibrio vulnificus es una de las especies de Vibrio más virulentas que se conocen. Es una bacteriade distribuciĂłn universal. El primer caso registrado en Uruguay se produjo en 2001, y desde entoncesocurren varias infecciones por año. Recientemente, en ese paĂs, V. vulnificus fue responsable de una infecciĂłnde partes blandas de curso letal. Aunque no han sido comunicados casos de infecciĂłn humana por esta especieen Argentina, se ha identificado recientemente Vibrio vulnificus en muestras asociadas con microplancton en elestuario del RĂo Negro. Presentamos el caso de una infecciĂłn grave de piel y partes blandas por V. vulnificus apartir de una herida abierta en un paciente en contacto con medio acuático marino en la costa de Uruguay delRĂo de la Plata. El aislamiento de vibrios en muestras de heridas puede causar un daño en los tejidos con rápidaprogresiĂłn, en particular V. vulnificus, que tiene una alta mortalidad sin la precoz y apropiada intervenciĂłn. Ennuestro caso, la rápida identificaciĂłn del microorganismo permitiĂł avalar el tratamiento empĂrico utilizado, conuna buena evoluciĂłn clĂnicaVibrio vulnificus is one of the most virulent Vibrio species known. It is a bacterium with universal distribution. The first case registered in Uruguay occurred in 2001 and, since then, several infections have occurred per year. Recently, in this country, V. vulnificus was responsible for a fatal soft tissue infection. Although no cases of human infection with this species have been reported in Argentina, researchers have recently identified V. vulnificus in samples associated with microplankton in the Rio Negro estuary. We present the case of a severe skin and soft tissue infection by V. vulnificus from an open wound in a patient in contact with a marine aquatic environment on the coast of the River Plate, in Uruguay. Isolation of vibrios from wound specimens can cause rapidly progressing tissue damage, particularly V. vulnificus which has a high mortality rate without early and appropriate intervention. In our case, the rapid identification of the microorganism allowed us to support the empirical treatment used, which a good clinical evolution.Fil: Almuzara, Marisa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Morales, Maia M.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Repetto, Silvia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Montaña, Sabrina Daiana. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Famiglietti, Angela MarĂa Rosa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Stecher, Daniel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Barberis, Claudia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Vay, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; Argentin
Vibrio vulnificus infection of the skin and soft parts: Communication of a case diagnosed in Argentina
Vibrio vulnificus es una de las especies de Vibrio más virulentas que se conocen. Es una bacteriade distribuciĂłn universal. El primer caso registrado en Uruguay se produjo en 2001, y desde entoncesocurren varias infecciones por año. Recientemente, en ese paĂs, V. vulnificus fue responsable de una infecciĂłnde partes blandas de curso letal. Aunque no han sido comunicados casos de infecciĂłn humana por esta especieen Argentina, se ha identificado recientemente Vibrio vulnificus en muestras asociadas con microplancton en elestuario del RĂo Negro. Presentamos el caso de una infecciĂłn grave de piel y partes blandas por V. vulnificus apartir de una herida abierta en un paciente en contacto con medio acuático marino en la costa de Uruguay delRĂo de la Plata. El aislamiento de vibrios en muestras de heridas puede causar un daño en los tejidos con rápidaprogresiĂłn, en particular V. vulnificus, que tiene una alta mortalidad sin la precoz y apropiada intervenciĂłn. Ennuestro caso, la rápida identificaciĂłn del microorganismo permitiĂł avalar el tratamiento empĂrico utilizado, conuna buena evoluciĂłn clĂnicaVibrio vulnificus is one of the most virulent Vibrio species known. It is a bacterium with universal distribution. The first case registered in Uruguay occurred in 2001 and, since then, several infections have occurred per year. Recently, in this country, V. vulnificus was responsible for a fatal soft tissue infection. Although no cases of human infection with this species have been reported in Argentina, researchers have recently identified V. vulnificus in samples associated with microplankton in the Rio Negro estuary. We present the case of a severe skin and soft tissue infection by V. vulnificus from an open wound in a patient in contact with a marine aquatic environment on the coast of the River Plate, in Uruguay. Isolation of vibrios from wound specimens can cause rapidly progressing tissue damage, particularly V. vulnificus which has a high mortality rate without early and appropriate intervention. In our case, the rapid identification of the microorganism allowed us to support the empirical treatment used, which a good clinical evolution.Fil: Almuzara, Marisa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Morales, Maia M.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Repetto, Silvia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Montaña, Sabrina Daiana. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Famiglietti, Angela MarĂa Rosa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Stecher, Daniel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Barberis, Claudia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Vay, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; Argentin
Comparison of different methods in order to identify Proteus spp.
The objectives were: (a) to identify Proteus strains to species level, following Farmer´s and O´Hara´s conventional biochemical reactions; b) to evaluate the sensitivity and specificity of both the API 20E method and a schema of reduced reactions (TSI and MIO agar: motility, indole and ornithine) comparing them with conventional methodology, and c) to evaluate the utility of SDS-PAGE (total proteins) in order to identify Proteus strains to species level. Two hundred and five Proteus spp. clinical isolates, were collected between January 1998 and September 2004, from inpatients and outpatients at Hospital de Clinicas. Strains were identified by means of conventional methodology, the API 20E method, and a schema of reduced reactions. SDS-PAGE (total proteins) was used in 48 out of the 205 strains. The API 20E method identified 79 out of 87 (90.8%) strains of P. mirabilis, 103 out of 103 P. vulgaris complex, and 15 out of 15 P. penneri. Eight strains of P. mirabilis were identified as Proteus spp., the acid production from maltose being necessary to identify them to species level. The schema of reduced reactions identified 205 out of 205 (100%) strains, that is, this schema of reduced reactions identified all the strains to species level without any additional tests, in marked contrast to the API 20E method. The SDS-PAGE (total proteins) identified the three species of the genus, even if the strains of P. mirabilis showed different biochemical reactions.Fil: Castro, Silvia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Rodriguez, Cynthia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Perazzi, Beatriz Elizabeth. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; ArgentinaFil: Sticotti, Marta Paz. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Muzio, Humberto. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Juarez, Josefina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Famiglietti, Angela MarĂa Rosa. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Santini, Pilar Imelda. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Vay, Carlos Alberto. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; Argentin
Increase in IS256 transposition in invasive vancomycin heteroresistant Staphylococcus aureus isolate belonging to ST100 and its derived VISA mutants
In Staphylococcus aureus, transposition of IS256 has been described to play an important role in biofilm formation and antibiotic resistance. This study describes the molecular characterization of two clinical heterogeneous vancomycin-intermediate S. aureus (hVISA) isolates recovered from the same patient (before and after antibiotic treatment) and two VISA derivatives obtained by serial passages in the presence of vancomycin. Our results showed that antibiotic treatment (in vivo and in vitro) could enhance IS256 transposition, being responsible for the eventual loss of agr function. As far as we know this is the first study that reports the increase of IS256 transposition in isogenic strains after antibiotic treatment in a clinical setting.Fil: Di Gregorio, Sabrina Noelia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de MicrobiologĂa, InmunologĂa y BiotecnologĂa. Cátedra de MicrobiologĂa; ArgentinaFil: Fernandez, Silvina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de MicrobiologĂa, InmunologĂa y BiotecnologĂa. Cátedra de MicrobiologĂa; ArgentinaFil: Perazzi, Beatriz Elizabeth. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Bello, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Famiglietti, Angela MarĂa Rosa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de BioquĂmica ClĂnica; ArgentinaFil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de MicrobiologĂa, InmunologĂa y BiotecnologĂa. Cátedra de MicrobiologĂa; Argentin
Bacteremia due to Dysgonomonas spp: A report of two cases
We report the first documented case of bacteremia caused by a Dysgonomonas species in a patient undergoing hemodialysis and a new case of bacteremia caused by D. capnocytophagoides in a patient with biliary tract infection.Fil: Almuzara, Marisa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de FisiopatologĂa y BioquĂmica ClĂnica; ArgentinaFil: Cittadini, Roxana. Sanatorio Mater Dei; ArgentinaFil: Ladelfa, Maria Fatima. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Complejo Medico Policial Bartolome Churruca Andres Visca; ArgentinaFil: Olivieri, Laura. No especifĂca;Fil: Ramirez, Maria Soledad. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; ArgentinaFil: Zamponi, Juan Carlos. Sanatorio Mater Dei; ArgentinaFil: Famiglietti, Angela MarĂa Rosa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de FisiopatologĂa y BioquĂmica ClĂnica; ArgentinaFil: Vay, Carlos Alberto. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de FisiopatologĂa y BioquĂmica ClĂnica; Argentin