Weighting Methods In The Construction Of Area Deprivation Indices

This study applies and compares several weighted average (WA) methods and Principal Component Analysis (PCA) for the construction of composite area-based deprivation index. The WA methods are based on weights that depend on standard deviation, correlation and data entropy. This paper also proposes three new approaches of WA method by suggesting their respective weights to depend on mean absolute deviation, inter-quartile range and data entropy where the probability is estimated by empirical density function and Gaussian kernel function. The deprivation indices produced by WA methods and PCA are then utilized to rank deprivation level of eighty-one administrative districts in Peninsular Malaysia

Concrete-filled FRP tubes: Manufacture and testing of new forms designed for improved performance

This paper reports on the development and testing of three new concrete-filled fiber-reinforced polymer (FRP) tube (CFFT) systems. These CFFT systems were designed to enhance the effectiveness of square and rectangular FRP tubes in confining concrete. In the design of the rectangular CFFTs two different enhancement techniques were considered; namely, corner strengthening and provision of an internal FRP panel. The technique used in the development of the square CFFT system involved the incorporation of four internal concrete-filled FRP cylinders as an integral part of the CFFT. The performance of these systems was investigated experimentally through axial compression tests of 10 unique CFFTs. The results of the experimental study indicate that the new CFFT systems presented in this paper offer significantly improved performance relative to conventional CFFTs with similar material and geometric properties. Examination of the test results have led to a number of significant conclusions with respect to the confinement effectiveness of each new CFFT system. These results are presented and a discussion is provided on the parameters that influenced the compressive behavior of these CFFT systems.Togay Ozbakkalogl

Dark States and Interferences in Cascade Transitions of Ultra-Cold Atoms in a Cavity

We examine the competition among one- and two-photon processes in an ultra-cold, three-level atom undergoing cascade transitions as a result of its interaction with a bimodal cavity. We show parameter domains where two-photon transitions are dominant and also study the effect of two-photon emission on the mazer action in the cavity. The two-photon emission leads to the loss of detailed balance and therefore we obtain the photon statistics of the cavity field by the numerical integration of the master equation. The photon distribution in each cavity mode exhibits sub- and super- Poissonian behaviors depending on the strength of atom-field coupling. The photon distribution becomes identical to a Poisson distribution when the atom-field coupling strengths of the modes are equal.Comment: 15 pages including 7 figures in Revtex, submitted to PR

Hemorragic complications organ of vision background of anticoagulating therapy

In the article, the problem of hemorrhagic complications (intraocular hemorrhages) is considered in ophthalmology, for patients accepting anticoagulatingt herapy. For comparison, patients were divided into groups on theaccepted preparations and by appearance hemorrhagic complications.В статье рассмотрена проблема геморрагических осложнений (интраокулярных кровоизлияний) в офтальмологии, у пациентов, принимающих антикоагулянтную терапию, для сравнения они были разделены на группы по принимаемым препаратам и по виду геморрагических осложнений

Axial compressive behavior of square and rectangular high-strength concrete-filled FRP tubes

This paper presents results of an experimental study on the behavior of square and rectangular high-strength concrete (HSC)-filled fiber-reinforced polymer (FRP) tubes (HSCFFT) under concentric compression. The effects of the tube thickness, sectional aspect ratio, and corner radius on the axial compressive behavior of concrete-filled FRP tubes (CFFT) were investigated experimentally through the tests of 24 CFFTs that were manufactured using unidirectional carbon fiber sheets and high-strength concrete with 78 MPa average compressive strength. As the first experimental investigation on the axial compressive behavior of square and rectangular HSCFFTs, the results of the study reported in this paper allow a number of significant conclusions to be drawn. First and foremost, test results indicate that sufficiently confined square and rectangular HSCFFTs can exhibit highly ductile behavior. The results also indicate that confinement effectiveness of FRP tubes increases with an increase in corner radius and decreases with an increase in sectional aspect ratio. It is also observed and discussed that HSCFFTs having tubes of low confinement effectiveness may experience a significant strength loss at the point of transition on their stress-strain curves. Furthermore, it is found that the behavior of HSCFFTs at this region differ from that of normal-strength CFFTs and that it is more sensitive to the effectiveness of a confining tube. Examination of the test results have also lead to a number of important observations on the influence of the key confinement parameters on the development and distribution of the hoop strains on the tubes of CFFTs, which are presented and discussed in the paper. © 2013 American Society of Civil Engineers.Togay Ozbakkalogl

Allopurinol desensitization with A 2 weeks modified protocol in an elderly patients with multiple comorbidities: a case report

BACKGROUND: Allopurinol is an effective urate-lowering drug that is well tolerated by the majority of patients. Patients with chronic renal insufficiency have an increased risk of hypersensitivity reactions with allopurinol. CASE PRESENTATION: 75 year old male patient with gout, renal insufficiency, history of metastatic colorectal carcinoma status post-resection was referred to Allergy clinic for a maculopapular eruption that developed 1 week after initiating therapy with allopurinol. The rash resolved with discontinuation of allopurinol. However, his serum urate level rose to 19.9 mg/dl. We initially proposed a slow 4 week oral allopurinol desensitization. The treating nephrologist felt it was critical to lower urate more rapidly. As a result, we modified the dose and standard 4 week protocol down to 2 weeks. A suspension of allopurinol was prepared by the allergy nurse practitioner with a 300 mg allopurinol tablet. The sensitization protocol was modified as a starting dose of 0.3 mg escalating to a final dose of 300 mg/day in 2 weeks. There was no reaction during or after the desensitization. The patient’s urate level normalized (6.3 mg/dl) and has continued on 300 mg allopurinol daily without reaction. CONCLUSION: A 2 week modified allopurinol desensitization protocol is a safe alternative for elderly patients with multiple comorbidities

Identification of De Novo Copy Number Variants Associated with Human Disorders of Sexual Development

Disorders of sexual development (DSD), ranging in severity from genital abnormalities to complete sex reversal, are among the most common human birth defects with incidence rates reaching almost 3%. Although causative alterations in key genes controlling gonad development have been identified, the majority of DSD cases remain unexplained. To improve the diagnosis, we screened 116 children born with idiopathic DSD using a clinically validated array-based comparative genomic hybridization platform. 8951 controls without urogenital defects were used to compare with our cohort of affected patients. Clinically relevant imbalances were found in 21.5% of the analyzed patients. Most anomalies (74.2%) evaded detection by the routinely ordered karyotype and were scattered across the genome in gene-enriched subtelomeric loci. Among these defects, confirmed de novo duplication and deletion events were noted on 1p36.33, 9p24.3 and 19q12-q13.11 for ambiguous genitalia, 10p14 and Xq28 for cryptorchidism and 12p13 and 16p11.2 for hypospadias. These variants were significantly associated with genitourinary defects (P = 6.08×10−12). The causality of defects observed in 5p15.3, 9p24.3, 22q12.1 and Xq28 was supported by the presence of overlapping chromosomal rearrangements in several unrelated patients. In addition to known gonad determining genes including SRY and DMRT1, novel candidate genes such as FGFR2, KANK1, ADCY2 and ZEB2 were encompassed. The identification of risk germline rearrangements for urogenital birth defects may impact diagnosis and genetic counseling and contribute to the elucidation of the molecular mechanisms underlying the pathogenesis of human sexual development