Woman’s Aesthetic Mission

This book forms the final, and arguably most significant chapter of Jacob Von Falke's notable book Art in the House - chapter x is titled 'Woman's Aesthetic Mission'. The mission of the book was to educate men in how to best display - or monitor their wives in displaying - art collections, everyday objects and furniture in a pleasing fashion within the home. The book might therefore be considered an original tome of interior design, persuading homeowners to enhance, decorate, arrange and furnish their homes to achieve a more aesthetically pleasing environment for the people using the space. Moreover, almost 150 years old, the text offers a glimpse into the expected codes of conduct for gendered roles ascribed to men and women in the 19th Century. However, we must ask ourselves, to what extent have things changed? There are surprising (and alarming) similarities with the denigration of women's capabilities in both their creation of artworks, and their perceived limitations in capability. Includes an introduction by Dr Helen Gorrill, feminist art historia

Geschichte des deutschen kunstgewerbes

Mode of access: Internet

CGAAL: Distributed On-The-Fly ATL Model Checker with Heuristics

We present CGAAL, our efficient on-the-fly model checker for alternating-time temporal logic (ATL) on concurrent game structures (CGS). We present how our tool encodes ATL as extended dependency graphs with negation edges, and employs the distributed on-the-fly algorithm by Dalsgaard et al. Our tool offers multiple novel search strategies for the algorithm, including DHS which is inspired by PageRank and uses the in-degree of configurations as an heuristic, IHS which estimates instability of assignment values, and LPS which estimates the distance to a state satisfying the constituent property using linear programming. CGS are input using our modeling language LCGS, where composition and synchronisation are easily described. We prove the correctness of our encoding, and our experiments show that our tool CGAAL is often one to three orders of magnitude faster than the popular tool PRISM-games on case-studies from PRISM’s documentation and among case-studies we have developed. In our evaluation we also compare and evaluate our search strategies, and find that our custom search strategies are often significantly faster than the usual breadth-first and depth-first search strategies.We present CGAAL, our efficient on-the-fly model checker for alternating-time temporal logic (ATL) on concurrent game structures (CGS). We present how our tool encodes ATL as extended dependency graphs with negation edges and employs the distributed on-the-fly algorithm by Dalsgaard et al. Our tool offers multiple novel search strategies for the algorithm, including DHS which is inspired by PageRank and uses the in-degree of configurations as a heuristic, IHS which estimates instability of assignment values, and LPS which estimates the distance to a state satisfying the constituent property using linear programming. CGS are input using our modelling language LCGS, where composition and synchronisation are easily described. We prove the correctness of our encoding, and our experiments show that our tool CGAAL is often one to three orders of magnitude faster than the popular tool PRISM-games on case studies from PRISM’s documentation and among case studies we have developed. In our evaluation, we also compare and evaluate our search strategies, and find that our custom search strategies are often significantly faster than the usual breadth-first and depth-first search strategies.</p

What is damaging the kidney in lupus nephritis?

Despite marked improvements in the survival of patients with severe lupus nephritis over the past 50 years, the rate of complete clinical remission after immune suppression therapy i

Size Doesn't Matter: Towards a More Inclusive Philosophy of Biology

notes: As the primary author, O’Malley drafted the paper, and gathered and analysed data (scientific papers and talks). Conceptual analysis was conducted by both authors.publication-status: Publishedtypes: ArticlePhilosophers of biology, along with everyone else, generally perceive life to fall into two broad categories, the microbes and macrobes, and then pay most of their attention to the latter. ‘Macrobe’ is the word we propose for larger life forms, and we use it as part of an argument for microbial equality. We suggest that taking more notice of microbes – the dominant life form on the planet, both now and throughout evolutionary history – will transform some of the philosophy of biology’s standard ideas on ontology, evolution, taxonomy and biodiversity. We set out a number of recent developments in microbiology – including biofilm formation, chemotaxis, quorum sensing and gene transfer – that highlight microbial capacities for cooperation and communication and break down conventional thinking that microbes are solely or primarily single-celled organisms. These insights also bring new perspectives to the levels of selection debate, as well as to discussions of the evolution and nature of multicellularity, and to neo-Darwinian understandings of evolutionary mechanisms. We show how these revisions lead to further complications for microbial classification and the philosophies of systematics and biodiversity. Incorporating microbial insights into the philosophy of biology will challenge many of its assumptions, but also give greater scope and depth to its investigations

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference