A Comparative Risk Assessment Of Burden Of Disease And Injury Attributable To 67 Risk Factors And Risk Factor Clusters In 21 Regions, 1990–2010: A Systematic Analysis For The Global Burden Of Disease Study 2010

Background Quantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a disease-by-disease analysis. No complete revision of global disease burden caused by risk factors has been done since a comparative risk assessment in 2000, and no previous analysis has assessed changes in burden attributable to risk factors over time

Childhood sexual abuse and suicidal behavior: a meta-analysis.

BACKGROUND AND OBJECTIVE: Self-inflicted injuries are one of the major causes of disease burden and death globally. Understanding the extent to which this is associated with childhood sexual abuse (CSA) exposure can help inform prevention strategies. We aimed to quantify to what extent CSA was associated with incident suicide attempts in men and women. METHODS: We searched 20 health and social science databases from first record until February 2009 and updated the search in Medline from February 2009 to February 1, 2013. Longitudinal studies and cotwin analyses from twin studies in any population from any year were eligible for inclusion. Of 22 235 abstracts screened as part of a series of reviews, 9 studies met the inclusion criteria for this review. Characteristics, effect estimates, and quality data were extracted. Random-effects meta-analysis was used to generate pooled odds ratios (ORs). RESULTS: Seven longitudinal and 2 twin studies with 8733 participants met the inclusion criteria. The overall pooled estimate for longitudinal studies was OR = 2.43 (95% confidence interval: 1.94-3.05), I(2) = 87.5%, P < .0001. The pooled OR from cotwin analysis was 2.65 (95% confidence interval: 0.82-4.49, I(2) = 0%, P = .867). Studies adjusted for a range of confounders, but baseline suicidal behavior was not well-controlled. Too few studies met the inclusion criteria to quantitatively examine sources of heterogeneity. CONCLUSIONS: CSA exposure is associated with suicide attempts when a range of different confounders are controlled for, but the temporality of the association is not well established, and the association is highly heterogeneous

Intimate partner violence victimization and alcohol consumption in women: a systematic review and meta-analysis.

AIMS: To examine the evidence of association between intimate partner physical or sexual violence (IPV) victimization and alcohol consumption in women. METHODS: We conducted a systematic review and meta-analysis of cross-sectional and longitudinal studies released before 6 June 2013. Studies providing an estimate of association between violence and alcohol consumption or alcohol use disorders were eligible for inclusion. Quality was assessed and random effects meta-analyses used to generate pooled odds ratios (OR) where appropriate. Higgins I(2) where P<0.10 was taken to indicate heterogeneity. RESULTS: Fifty-five studies providing 102 estimates of association met the inclusion criteria. Most estimates were not controlled for partner alcohol use and other key confounders. Seven longitudinal studies provided 12 estimates of the association between alcohol and subsequent IPV; nine of 12 estimates showed a direction of increased odds of subsequent IPV, pooled OR=1.27 [95% confidence interval (CI)=1.07-1.52], I(2) =0%, P=0.437. Nine longitudinal studies provided 15 estimates of association between IPV and subsequent alcohol use; 14 of 15 estimates showed a direction of increased odds of subsequent alcohol use, pooled OR=1.25 (95% CI 1.02-1.52), I(2)=0%, P=0.751. Cross-sectional studies showed an association between IPV and alcohol use, pooled OR=1.80, 95% CI 1.58-2.06, but with substantial heterogeneity, I(2)=60.8%, P<0.0001. Definition of alcohol use partly accounted for heterogeneity in cross-sectional estimates. CONCLUSIONS: There is a clear positive association between alcohol use and intimate partner physical or sexual violence victimization among women, suggesting a need for programming and research that addresses this link. However, the temporal direction of the association remains unclear. Longitudinal studies with multiple waves of data collection are needed

Flow of studies through the review.

<p>Flow of studies through the review.</p

Meta-analyses of the association between IPV and depressive symptoms or disorder in women.

<p>Meta-analyses of the association between IPV and depressive symptoms or disorder in women.</p

Summary of studies of depression and IPV, in men.

a<p><i>p</i>-Value if no confidence nterval reported.</p>b<p>Other childhood trauma.</p>c<p>More than one type of violence measured but only one estimate included here.</p><p>BDI, Beck Depression Inventory; CES-D-C, Center for Epidemiologic Studies–Depression–Children; CI, confidence interval; CTS, Conflict Tactics Scale; DICA-R-A, Diagnostic Interview for Children and Adolescents–Revised–Adolescents; MINI, Mini-International Neuropsychiatric Interview.</p

Summary of studies of suicide and IPV, in men.

<p>All studies measured IPV and incident suicide attempts.</p>a<p><i>p</i>-Value if no confidence interval reported.</p>b<p>Other childhood trauma.</p><p>CI, confidence interval; CTS, Conflict Tactics Scale.</p

Summary of studies of suicide and IPV, in women.

<p>All studies measured IPV and incident suicide attempts.</p>a<p><i>p</i>-Value if no confidence interval reported.</p>b<p>Other childhood trauma.</p>c<p>More than one type of violence measured but only one estimate included here.</p><p>CI, confidence interval; CTS, Conflict Tactics Scale.</p

Summary of studies of depression and IPV, in women.

a<p><i>p</i>-Value if no confidence interval reported.</p>b<p>Other childhood trauma.</p>c<p>More than one type of violence measured but only one estimate included here.</p><p>AAS, Abuse Assessment Screen; BDI, Beck Depression Inventory; BDI-II, Beck Depression Inventory–II; BSI, Brief Symptom Inventory; CES-D-C, Center for Epidemiologic Studies–Depression–Children; CI, confidence interval; CIDI-SF, Composite International Diagnostic Interview–Short Form; CIS-R, Clinical Interview Schedule–Revised; CTS, Conflict Tactics Scale; DICA-R-A, Diagnostic Interview for Children and Adolescents–Revised-Adolescents; MINI, Mini-International Neuropsychiatric Interview; SVAWS, Severity of Violence Against Women Scales; WHO, World Health Organization.</p

Intimate partner violence and incident depressive symptoms and suicide attempts: a systematic review of longitudinal studies.

BACKGROUND: Depression and suicide are responsible for a substantial burden of disease globally. Evidence suggests that intimate partner violence (IPV) experience is associated with increased risk of depression, but also that people with mental disorders are at increased risk of violence. We aimed to investigate the extent to which IPV experience is associated with incident depression and suicide attempts, and vice versa, in both women and men. METHODS AND FINDINGS: We conducted a systematic review and meta-analysis of longitudinal studies published before February 1, 2013. More than 22,000 records from 20 databases were searched for studies examining physical and/or sexual intimate partner or dating violence and symptoms of depression, diagnosed major depressive disorder, dysthymia, mild depression, or suicide attempts. Random effects meta-analyses were used to generate pooled odds ratios (ORs). Sixteen studies with 36,163 participants met our inclusion criteria. All studies included female participants; four studies also included male participants. Few controlled for key potential confounders other than demographics. All but one depression study measured only depressive symptoms. For women, there was clear evidence of an association between IPV and incident depressive symptoms, with 12 of 13 studies showing a positive direction of association and 11 reaching statistical significance; pooled OR from six studies = 1.97 (95% CI 1.56-2.48, I²  =  50.4%, p(heterogeneity = 0.073). There was also evidence of an association in the reverse direction between depressive symptoms and incident IPV (pooled OR from four studies = 1.93, 95% CI 1.51-2.48, I²  =  0%, p = 0.481). IPV was also associated with incident suicide attempts. For men, evidence suggested that IPV was associated with incident depressive symptoms, but there was no clear evidence of an association between IPV and suicide attempts or depression and incident IPV. CONCLUSIONS: In women, IPV was associated with incident depressive symptoms, and depressive symptoms with incident IPV. IPV was associated with incident suicide attempts. In men, few studies were conducted, but evidence suggested IPV was associated with incident depressive symptoms. There was no clear evidence of association with suicide attempts