Testing quark mass matrices with right-handed mixings

In the standard model, several forms of quark mass matrices which correspond to the choice of weak bases lead to the same left-handed mixings $V_L=V_{CKM}$, while the right-handed mixings $V_R$ are not observable quantities. Instead, in a left-right extension of the standard model, such forms are ansatze and give different right-handed mixings which are now observable quantities. We partially select the reliable forms of quark mass matrices by means of constraints on right-handed mixings in some left-right models, in particular on $V^R_{cb}$. Hermitian matrices are easily excluded.Comment: 12 pages RevTex, no figures. Minor corrections. Comment on SO(10) changed and one reference adde

Leptogenesis and neutrino parameters

We calculate the baryonic asymmetry of the universe in the baryogenesis-via-leptogenesis framework, assuming first a quark-lepton symmetry and then a charged-neutral lepton symmetry. We match the results with the experimentally favoured range. In the first case all the oscillation solutions to the solar neutrino problem, except the large mixing matter solution, can lead to the allowed range, but with fine tuning of the parameters. In the second case the general result is quite similar. Some related theoretical hints are discussed.Comment: RevTex, 21 pages with 8 figure

Antenna on chip (Aoc) design using metasurface and siw technologies for thz wireless applications

This paper presents the design of a high-performance 0.45-0.50 THz antenna on chip (AoC) for fabrication on a 100-micron GaAs substrate. The antenna is based on metasurface and substrate-integrated waveguide (SIW) technologies. It is constituted from seven stacked layers consisting of copper patch-silicon oxide-feedline-silicon oxide-aluminium-GaAs-copper ground. The top layer consists of a 2 x 4 array of rectangular metallic patches with a row of subwavelength circular slots to transform the array into a metasurface. This essentially enlarges the effective aperture area of the antenna. The antenna is excited using a coplanar waveguide feedline that is sandwiched between the two silicon oxide layers below the patch layer. The proposed antenna structure reduces substrate loss and surface waves. The AoC has dimensions of 0.8 x 0.8 x 0.13 mm(3). The results show that the proposed structure greatly enhances the antenna's gain and radiation efficiency, and this is achieved without compromising its physical size. The antenna exhibits an average gain and efficiency of 6.5 dBi and 65%, respectively, which makes it a promising candidate for emerging terahertz applications

Increased levels of RNA oxidation enhance the reversion frequency in aging pro-apoptotic yeast mutants

Despite recent advances in understanding the complexity of RNA processes, regulation of the metabolism of oxidized cellular RNAs and the mechanisms through which oxidized ribonucleotides affect mRNA translation, and consequently cell viability, are not well characterized. We show here that the level of oxidized RNAs is markedly increased in a yeast decapping Kllsm4Δ1 mutant, which accumulates mRNAs, ages much faster that the wild type strain and undergoes regulated-cell-death. We also found that in Kllsm4Δ1 cells the mutation rate increases during chronological life span indicating that the capacity to han- dle oxidized RNAs in yeast declines with aging. Lowering intracellular ROS levels by antioxidants recovers the wild- type phenotype of mutant cells, including reduced amount of oxidized RNAs and lower mutation rate. Since mRNA oxidation was reported to occur in different neurodegen- erative diseases, decapping-deficient cells may represent a useful tool for deciphering molecular mechanisms of cell response to such conditions, providing new insights into RNA modification-based pathogenesis

H-IPSE is a pathogen-secreted host nucleus infiltrating protein (infiltrin) expressed exclusively by the Schistosoma haematobium egg stage

Urogenital schistosomiasis, caused by the parasitic trematode Schistosoma haematobium, affects over 112 million people worldwide. As with S. mansoni infections, the pathology in urogenital schistosomiasis is mainly related to the egg stage, which induces granulomatous inflammation of affected tissues. Schistosoma eggs and their secretions have been studied extensively for the related S. mansoni organism which is more amenable to laboratory studies. Indeed, we have shown that IPSE/alpha-1 (M-IPSE herein), a major protein secreted from S .mansoni eggs, can infiltrate host cells. Although M-IPSE function is unknown, its ability to translocate to their nucleus and bind DNA suggests a possible role in immune modulation of host cell tissues. Whether IPSE homologs are expressed in other Schistosome species has not been investigated. Here, we describe the cloning of two paralog genes H03-IPSE and H06-IPSE which are the ortholog of M-IPSE, from the egg-cDNA of S. haematobium. Using PCR and immunodetection, we confirmed that expression of these genes is restricted to the egg stage and female adult worms, while H-IPSE protein is only detectable in mature eggs but not adults. We show that both H03-IPSE and H06-IPSE proteins can infiltrate HTB-9 bladder cells when added exogenously to culture medium. Monopartite C-terminal NLS motifs conserved in H03-IPSE ‘SKRRRKY’ and H06-IPSE ‘SKRGRKY’ NLS motifs, are responsible for targeting the proteins to the nucleus of HTB-9 cells, as demonstrated by site directed mutagenesis and GFP tagging. Thus, S. haematobium eggs express IPSE homologs that appear to perform similar functions in infiltrating host cells

Model for fermion mass matrices and the origin of quark-lepton symmetry

Several phenomenological features of fermion masses and mixings can be accounted for by a simple model for fermion mass matrices, which suggests an underlying U(2) horizontal symmetry. In this context, it is also proposed how an approximate quark-lepton symmetry can be achieved without unified gauge theories.Comment: 12 pages, RevTex. Minor changes, some references adde

Improved adaptive impedance matching for RF front-end systems of wireless transceivers

In this paper an automatic adaptive antenna impedance tuning algorithm is presented that is based on quantum inspired genetic optimization technique. The proposed automatic quantum genetic algorithm (AQGA) is used to find the optimum solution for a low-pass passive T-impedance matching LC-network inserted between an RF transceiver and its antenna. Results of the AQGA tuning method are presented for applications across 1.4 to 5 GHz (satellite services, LTE networks, radar systems, and WiFi bands). Compared to existing genetic algorithm-based tuning techniques the proposed algorithm converges much faster to provide a solution. At 1.4, 2.3, 3.4, 4.0, and 5.0 GHz bands the proposed AQGA is on average 75%, 49.2%, 64.9%, 54.7%, and 52.5% faster than conventional genetic algorithms, respectively. The results reveal the proposed AQGA is feasible for real-time application in RF-front-end systems

Metamaterial based design of compact UWB/MIMO monopoles antenna with characteristic mode analysis

In this article, a novel metamaterial inspired UWB/multiple-input-multiple-output (MIMO) antenna is presented. The proposed antenna consists of a circular metallic part which formed the patch and a partial ground plane. Metamaterial structure is loaded at the top side of the patches for bandwidth improvement and mutual coupling reduction. The proposed antenna provides UWB mode of operation from 2.6-12 GHz. The characteristic mode theory is applied to examine each physical mode of the antenna aperture and access its many physical parameters without exciting the antenna. Mode 2 was the dominant mode among the three modes used. Considering the almost inevitable presence of mutual coupling effects within compact multiport antennas, we developed an additional decoupling technique in the form of perturbed stubs, which leads to a mutual coupling reduction of less than 20 dB. Finally, different performance parameters of the system, such as envelope correlation coefficient (ECC), channel capacity loss (CCL), diversity gain, total active reflection coefficient (TARC), mean effective gain (MEG), surface current, and radiation pattern, are presented. A prototype antenna is fabricated and measured for validation