Immune Complex Deposition in the Choroid Plexus of Patients with Acquired Immunodeficiency Syndrome

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2016-07-08T18:14:29Z No. of bitstreams: 1 Falangola MF Immune complex....pdf: 401943 bytes, checksum: 6ca566ebe1f3967dfb946e0c68e2db69 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2016-07-08T18:39:19Z (GMT) No. of bitstreams: 1 Falangola MF Immune complex....pdf: 401943 bytes, checksum: 6ca566ebe1f3967dfb946e0c68e2db69 (MD5)Made available in DSpace on 2016-07-08T18:39:19Z (GMT). No. of bitstreams: 1 Falangola MF Immune complex....pdf: 401943 bytes, checksum: 6ca566ebe1f3967dfb946e0c68e2db69 (MD5) Previous issue date: 1994Made available in DSpace on 2016-07-22T13:10:49Z (GMT). No. of bitstreams: 3 Falangola MF Immune complex.pdf.txt: 17730 bytes, checksum: d0ef63caf44bac15f4ca352e64678441 (MD5) Falangola MF Immune complex.pdf: 401943 bytes, checksum: 6ca566ebe1f3967dfb946e0c68e2db69 (MD5) license.txt: 2991 bytes, checksum: 5a560609d32a3863062d77ff32785d58 (MD5) Previous issue date: 1994Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Miami School of Medicine. Department of Pathology. Miami, Floridaplexus of approximately 75% of patients with acquired immunodeficiency syndrome (AIDS) who had either normal brains or human immunodeficiency virus encephalitis. Since circulating immune complexes are common in AIDS patients, and since local choroid plexus pathology usually was absent, their likely origin is from the bloodstream. Choroid plexus deposits of immune complexes have been implicated in altering the function of this structure or in enhancing its vulnerability to infection. Therefore, immune complex deposition in the choroid plexus of AIDS patients may be responsible for some of the common alterations in the cerebrospinal fluid and for the frequency of opportunistic infections in this region

HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2016-08-29T13:32:53Z No. of bitstreams: 1 Falangola MF HIV infection of human....pdf: 532706 bytes, checksum: 4dc92111e3a15f88d237790b55d67cad (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2016-08-29T16:21:24Z (GMT) No. of bitstreams: 1 Falangola MF HIV infection of human....pdf: 532706 bytes, checksum: 4dc92111e3a15f88d237790b55d67cad (MD5)Made available in DSpace on 2016-08-29T16:21:24Z (GMT). No. of bitstreams: 1 Falangola MF HIV infection of human....pdf: 532706 bytes, checksum: 4dc92111e3a15f88d237790b55d67cad (MD5) Previous issue date: 1995National Institutes of Health NINDS e Conselho Nacional de Desenvolvimento Científico e TecnológicoFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Miami School of Medicine. Department of Pathology. FL, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Miami School of Medicine. Department of Pathology. FL, USAThe present study examines the hypothesis that HIV infection of the choroid plexus (CPx) may be an important site of viral entry into the brain. Formalin-fixed, paraffin-embedded CPx was obtained from 25 patients with AIDS and 13 nonAIDS patients and was processed for light microscopy and for immunohistochemical detection of HIV gp41, T and B lymphocytes, monocytes/macrophages and endothelial cells. Eleven of the 13 nonAIDS CPx were normal and 2 contained inflammatory foci of undetermined etiology. The stroma contained T lymphocytes in all and monocytes in 22%; B lymphocytes and HIV antigen were absent. Choroid plexus of the AIDS cases contained opportunistic infections or lymphoma in 12 and inflammatory foci alone in 6; 7 were normal. T lymphocytes were present in 70% and monocytes in 50%. In addition to the stromal localization, monocytes also were present in supra-epithelial regions and within or adjacent to the capillary endothelium. HIV-positive cells in the CPx were found in 11 cases (44%) and in the supra-epithelial area in another 2. Their presence correlated with neither infection nor lymphoma of the CPx or brain. They were situated in the stroma, supra-epithelial region and (rarely) capillary endothelium. Immunohistochemistry on serial sections identified the HIV-infected cells as monocytes, including those by capillary endothelium and in supra-epithelial areas. The study demonstrates that the CPx contains HIV-infected monocytes in almost half of the cases. Their apposition to endothelium suggests hematogenous origin. These results support the hypothesis that HIV encephalitis may develop from CPx infectio

Induced tolerance to Schistosoma mansoni antigens modulates periovular granuloma.

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2012-10-26T19:05:27Z No. of bitstreams: 1 Sadigursky M Induced tolerance to Schistosoma....pdf: 150019 bytes, checksum: c8bf3b1fdfb4dfefdde63908c795408c (MD5)Made available in DSpace on 2012-10-26T19:05:27Z (GMT). No. of bitstreams: 1 Sadigursky M Induced tolerance to Schistosoma....pdf: 150019 bytes, checksum: c8bf3b1fdfb4dfefdde63908c795408c (MD5) Previous issue date: 1987Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHarward Medical School. Boston, USAImmunological tolerance to Schistosoma mansoni antigens induced by oral exposure of neonatal and adult mice to adult worm, soluble egg and polysaccharide antigens conducted to modulated periovular granuloma of infected mice. However the tolerance do not interfere in the infection. The estimative population and subpopulation of lymphocytes in the spleen of tolerized (not infected) animals do not differ from normal animals but Lyt 2.2 reactive lymphocytes to Schistosoma antigens was demonstrated in the tolerized animals