Prevalence, causes, and complications of acute kidney transplant rejection: survey in a single center

Backgrounds: Kidney transplantation has become a preferred surgical approach for several renal disorders. To acquire required information in basis of acute transplant rejection and its complications, it is important to determine rejection prevalence and its potential causes.Methods: In present retrospective study, during a 37-year survey, 2250 patients received conventional kidney transplantation. The patients who had suffered graft loss, death, and nephrectomy of transplanted kidney during the first month after transplantation enrolled the study and all required data recorded in designed questionnaire. Results: Of 2557 patients underwent kidney transplantation, 86 (3.36%) patients were suffered acute graft loss during the first month after transplantation, that 43 (50%) were males and 43 (50%) were females. Mean age of the patients with acute graft loss was 40.09±14.09. The most common underlying cause for acute graft loss in our study were as follows: acute rejection of transplanted kidney (34.9%), renal vein thrombosis (17.5%), heart infarction (13.9%), idiopathic (6.9%). Of 86 patients, thirty-three patients underwent nephrectomy subsequent to rejection, however, fifty-three patients well responded to medical treatment. In our study the amount of acute nephrectomy during the first month after transplantation was 38.4% (33 patients) which constituted 1.2% of the total graft losses.Conclusion: Renal vein thrombosis is the most common underlying reason for graft loss in kidney transplantation patients, and 1st week of the transplantation is the most probable postoperative time for graft rejection

Double strain probiotic effect on Helicobacter pylori infection treatment: A double-blinded randomized controlled trial

Background: A decreased rate of successful helicobacter pylori (H.pylori) infection treatment has revealed serious demand for more effective regimens to eradicate infection. Therefore, probiotics have recently been considered to increase the rate of antibiotic regimens efficacy in H. pylori infections. In current randomized controlled trial, we evaluated the effect of double strain probiotic combination with standard triple therapy (STT), in the eradication rate of H. pylori infection. Methods: In current randomized placebo-control study, all patients (176 subjects) underwent the STT for 10 days. However, the study group received triple therapy for the eradication of H. pylori with supplement of Lactobacillus probiotic for 4 weeks and placebo was administered to control group, as well. Adverse effects of the antibiotic regimen were recorded for all patients. Six weeks after the cessation of probiotic intake, all patients underwent H. Pylori with fecal antigen of test, followed by a recurrence evaluation six months later. Results: There was no significant difference in demographic data and presenting symptoms between the study groups. The eradication rate of H. pylori infection was significantly higher in probiotic group (78.4%), compared to that of placebo group (64.8%) (P=0.033). In addition, adverse events were significantly less prevalent in patients that received probiotic (P=0.047). Nonetheless, there was no significant difference in terms of infection recurrence during a 6-month follow-up (P=0.07). Conclusion: Double strain probiotic in combination with STT increased the eradication rate of H. pylori infection, while the adverse events due to antibiotic therapy decrease

Evaluation of the VANRIS Injection Success Rate in Vesicoureteral Reflux (VUR) Treatment in Children

Background: Vesicoureteral reflux (VUR) is a common condition among children. Although, subureteral injection is a minimally invasive new method for VUR treatment, ideal bulking agent in endoscopic treatment still remains controversial. We aimed to evaluate VANTRIS subureteral injection efficacy in VUR treatment in pediatric patients. Materials and Methods: All patients who referred to Imam Khomeini hospital in Urmia-Iran, Urology ward with VUR diagnosis that had indications for open surgery, enrolled study (during Mar 2013 to Mar 2015). Prior to intervention, VUR severity, urinary tract infection (UTI) and subsequent complications determined using urine analysis and imaging. Subsequently, single injection of the VANTRIS performed for all patients and patients underwent six-month follow up including several clinical and paraclinical evaluations. Results: 31 patients with VUR diagnosis participated; of 31 patients, 18 (58.06%) children with primary UTI who had surgery indication enrolled study; of 18 patients, seven patients (38.88%) were boy and eleven patients (61.12%) were girl with mean age of 6.88 ± 2.61 years, and out of 29 refluxing rental units (RRU), 13 (44.8%) were right and 16 (55.2%) were left kidney. In current study, patients divided to two subgroups regarding their age older than five or younger than five years old and there was no significant difference between the resolution rates following VANTRIS injection in two groups (P>0.05). Eleven (38.88%) RRU detected in boy patients, nonetheless VUR resolved in all of them, postoperatively. On the other hand, of 18 RRU in female patients, complete VUR resolution observed in 16 kidneys (88.8 %), but only 2 (11.11%) kidneys had incomplete, but significant VUR resolution, where no significant difference observed. The prevalence of reflux in patients with UTI was 30% and in patients without UTI was 17%. Conclusion: The current study indicated that in all age groups of patients, the subureteral injection of the VANTRIS was an accurate and effective treatment modality for VU

Study of Vitamin D Level in Children with Non-specific Musculoskeletal Pain

BackgroundVitamin D deficiency is known as a one of the underlying causes of Idiopathic musculoskeletal pain (IMSP). This study aimed to evaluate the correlation between serum vitamin D (Cholecalciferol) status in patient with Non-specific Musculoskeletal Pain and healthy children.Materials and MethodsSeventy-seven children (aged 3–14 years), with IMSP were included as cases and 90 healthy subjects were selected for control group. Demographic characteristics and biochemical levels of vitamin D and Parathyroid hormone (PTH), were obtained. Data were analysis using SPSS version 17.0 software.ResultsResults showed that vitamin D means levels of patients and healthy children were significantly different (19.5 + 8.84 ng/mL versus 12.7 + 11.89 ng/mL), respectively (