An in-vitro evaluation of skin protection factor of non-polar date seed extract from three different date varieties Ajwa, Aseel and Khapra by UV spectrophotometry

Objective: Skin is the primary layer of human body which act as protective barrier against exogenous chemicals, UV radiations as well as microorganisms. Maintaining the skin morphology under regular environmental stresses and controlling age related skin changes is one of the biggest challenges for modern science, pharmaceutical and cosmetics industry. These environmental stresses, such as excessive exposure to UV radiations, can even lead to the devastating skin disorders such as skin cancer. Dates seed has capability to protect skin against the damages caused by solar radiations, which mostly appear in the forms of wrinkles and some other skin related issues. Methods: Therefore, current research is focused on to analyze sun protection factor (SPF) of two non-polar fractions obtained from crushed seeds of three different varieties of i.e., Ajwa, Aseel and Khapra. Results: Results indicate that the highest value of SPF was found in AEA i.e., 15.061 at 200ppm while no difference was observed in the SPF values of KPPE. Conclusion: Hence, it could be concluded that the ethyl acetate fraction of all date seed varieties could be potential Ajwa, Aseel and Khapra could be a promising source of cosmetic and pharmaceutical preparations due to the potential SPF value except petroleum ether of Khapra extract

Phytochemical characterization, antioxidant activity and antihypertensive evaluation of Ocimum basilicum L. in l-NAME induced hypertensive rats and its correlation analysis

Ocimum basilicum Linn. (basil) is an aromatic culinary herb that has shown a great potential in therapeutic world. It has many promising pharmacological activities that make it centre for investigations for many researchers. Current study has been planned to determine chemical constituents of basil leaves extracts and their in-vitro and ex-vivo antioxidant and in-vivo antihypertensive potential. GC-MS studies of non-polar extracts showed presence of 75 compounds including monoterpenes, hydrocarbons, sesquiterpenes, triterpenes, phyto-sterols and phthalates. Higher percentages of fatty acids were also identified. The major compounds include linalool (7.65%), terpineol (1.42%), tau-cadinol (13.55%), methyl palmitate (14.24%), palmitic acid (14.31%), linolenic acid (1.30%) and methyl linolenate (17.72%). Electron spray ionization mass spectrometry ESI-HRMS/MS of the polar extracts revealed the presence of alkaloids, phenolic acid, amino acid, coumarin, lignin, flavanoid and terpene derivative. Total phenolic content and total flavonoid content were determined using spectrophotometric technique and calculated as gallic acid equivalents GAE/g dry weight and rutin equivalent RE/g of dry weight respectively. The highest phenolic content and flavonoid content were found in ethyl acetate extract 9.40 mg GAE/g and 15.9 mg RE/g of dry weight. All the extracts showed significant antioxidant activity in DPPH and ABTS cation decolorization assays. Dichloromethane extract possess the highest DPPH scavenging activity, i.e., 64.12% ± 0.23 at concentration of 4 mg/ml. Moreover in ex-vivo studies all the extracts showed prominent effect by inhibiting AAPS induce oxidation in Human erythrocytes being 69.24% ± 0.18 in dichloromethane extract, 64.44% ± 0.04 in ethyl acetate and 53.33% ± 0.09 in acetone extract. The methanol extract of O. basilicum exhibited significant decrease in systolic blood pressure in l-Name induced hypertensive rats at the dose of 50 mg/kg for 28 days. Total phenolic content had a higher linear correlation (r = 0.678) with antihypertensive activity, with a level of significance 95% showing that phenolic compounds in the leaves of the plant has important role in inhibiting l –NAME induced hypertension while flavonoid compounds may play a key role in the antioxidant activities of the plant, through synergism. Conclusively, O. basilicum leaves with bioactive metabolites are a potential source for the development of antihypertensive drugs

Synthesis of Mannich Bases of 8-Hydroxyquinoline

In search of new potential therapeutic agents, 8-Hydroxyquinoline which is a highly active antifungal and antibacterial agent was subjected to Mannich reaction. Different combinations of aromatic aldehyde and aromatic amines were used for Mannich reaction on 8-Hydroxyquinoline from which one new 7-[α-(anilino)-3',4'-dimethoxybenzyl]-8-hydroxyquinoline (3) and two known Mannich bases (1,2) were obtained

A Novel Multi-Criteria Group Decision-Making Approach Based on Bonferroni and Heronian Mean Operators under Hesitant 2-Tuple Linguistic Environment

Ambiguous and uncertain facts can be handled using a hesitant 2-tuple linguistic set (H2TLS), an important expansion of the 2-tuple linguistic set. The vagueness and uncertainty of data can be grabbed by using aggregation operators. Therefore, aggregation operators play an important role in computational processes to merge the information provided by decision makers (DMs). Furthermore, the aggregation operator is a potential mechanism for merging multisource data which is synonymous with cooperative preference. The aggregation operators need to be studied and analyzed from various perspectives to represent complex choice situations more readily and capture the diverse experiences of DMs. In this manuscript, we propose some valuable operational laws for H2TLS. These new operational laws work through the individual aggregation of linguistic words and the collection of translation parameters. We introduced a hesitant 2-tuple linguistic weighted average (H2TLWA) operator to solve multi-criteria group decision-making (MCGDM) problems. We also define hesitant 2-tuple linguistic Bonferroni mean (H2TLBM) operator, hesitant 2-tuple linguistic geometric Bonferroni mean (H2TLGBM) operator, hesitant 2-tuple linguistic Heronian mean (H2TLHM) operator, and a hesitant 2-tuple linguistic geometric Heronian mean (H2TLGHM) operator based on the novel operational laws proposed in this paper. We define the aggregation operators for addition, subtraction, multiplication, division, scalar multiplication, power and complement with their respective properties. An application example and comparison analysis were examined to show the usefulness and practicality of the work