Measuring airway mucin 2 in patients with severe chronic obstructive pulmonary disease with bacterial colonization

Sibila and colleagues reported an analysis of the levels of the secreted polymeric mucins MUC2, MUC5AC, and MUC5B in the sputum and bronchoalveolar lavage fluid of patients with severe chronic obstructive pulmonary disease (COPD) (1). We are writing because they found a very high level of MUC2 in both specimens, whereas most recent studies by others find little or no MUC2 in the airway. Therefore, this report raises the possibility of an error in measurement that could cause confusion in the field

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein

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