1,082 research outputs found

    Effects of cervical muscle fatigue on the perception of the subjective vertical and horizontal

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    Introduction: Cervical functional capacity outcome measures that are simple and reliable are urgently needed in order permit accurate assessment/reassessment during treatments and rehabilitation. Induced neck muscle fatigue has been shown to alter functional capacities such as balance and kinaesthetic sense in the standing posture. The Rod and Frame Test has also shown promise as a method of assessing the effects of chronic neck pain and injury, but currently only in the sitting position. The objectives of this project were therefore 1) to validate the computerised rod and frame test in the standing posture, and 2) to measure the effects that different cervical muscle fatigue protocol would have on the assessment of the subjective visual vertical and horizontal. Method: The validation of the standing computerised rod and frame test in the standing posture was obtained by comparing results (n = 74) between the sitting and standing positions with the Spearman's correlation coefficient. In addition, agreement between the two methods was analysed with the Bland-Altman method. Participants (n = 56) resisted with their neck muscles approximately 35% maximum isometric voluntary contraction force for 15 minutes on a purpose built apparatus in eight different directions. Wilcoxon signed rank tests analysed changes in horizontal and vertical rod and frame test between the neutral and all different directions of contraction. The changes of recorded unsigned vertical and horizontal errors for the combined frame condition in all situations of isometric contraction were analysed with two respective one-way repeated measures analysis of variance (ANOVA). Discussion: The Spearman's rho and Bland-Altman plots show that the Rod and Frame Test works equally well in sitting and standing positions. After muscle contraction, there were significant increases in error in all participants for both horizontal and vertical rod and frame tests, except after flexion. These errors were predominantly present after fatigue of muscles in the coronal plane of contraction. Proprioception alone cannot explain the difference in the rod and frame results between different muscle groups. It is suggested that an evolutionary advantage of developing improved subjective verticality awareness in the same direction as the main visual field could explain these findings. © 2014 Gosselin and Fagan

    Foam pads properties and their effects on posturography in participants of different weight

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    Background: Foam pads are increasingly used on force platforms during balance assessments in order to produce increased instability thereby permitting the measurement of enhanced posturographic parameters. A variety of foam pads providing different material properties have thus been used, although it is still unclear which characteristics produce the most effective and reliable tests. Furthermore, the effects of participant bodyweight on the performance of the foam pads and outcome of the test are unknown. This project investigated how different foam samples affected postural sway velocity in participants of different weights. Method: Four foam types were tested according to a modified American Society for Testing and Materials standard method for testing flexible cellular materials. Thirty-six healthy male factory workers divided into three groups according to body mass were tested three times for each of the 13 randomly-selected experimental situations for changes in postural sway velocity in this cross-over study. Descriptive and inferential statistics were used to compare the results and evaluate the difference in sway velocity between mass groups. Results: For the materials considered here, the modulus of elasticity of the foam pads when compressed by 25% of their original heights was inversely proportional to their density. The largest changes in postural sway velocity were measured when the pads of highest stiffness were used, with memory foam pads being the least likely to produce significant changes. Conclusions: The type of foam pads used in posturography is indeed important. Our study shows that the samples with a higher modulus of elasticity produced the largest change in postural sway velocity during quiet stance. The results suggest that foam pads used for static computerised posturography should 1) possess a higher modulus of elasticity and 2) show linear deformation properties matched to the participants’ weight

    The effects of cervical muscle fatigue on balance - A study with elite amateur rugby league players

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    Neck muscle fatigue has been shown to alter an individual’s balance in a similar way to that reported in subjects suffering from neck pain or subjects that have suffered a neck injury. The main purpose of the present study was to quantify the effects of neck fatigue on neck muscle electromyography (EMG) activity, balance, perceived fatigue and perceived stability. Forty four elite amateur rugby league players resisted with their neck muscles approximately 35% maximum voluntary isometric contraction (MVIC) force for 15 minutes in eight different directions. Sway velocity and surface electromyography were measured. Questionnaires were used to record perceived effort and stability. Repeated measures ANOVA showed that after 15 minutes isometric contraction, significant changes were seen in sway velocity, perceived sway and EMG median frequency. There were no differences in perceived efforts. The changes in sway velocity and median frequency were more pronounced after extension and right and left posterior oblique contractions but there was no significant difference in sway velocity after contraction in the right lateral flexion, right anterior oblique and left anterior oblique direction of contraction. All the subjects showed oriented whole-body leaning in the plane of the contraction. The experiment produced significantly altered and perceived altered balance in this group of physically fit individuals. The results may contribute to our understanding of normal functional capacities of athletes and will provide a basis for further investigation in healthy non-athletes and participants that have suffered neck injuries. This may ultimately help develop accurate and valid rehabilitation outcome measures

    Development and three-dimensional morphology of the zygomaticotemporal suture in primate skulls

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    Cranial sutures are an essential part of the growing skull, allowing bones to increase in size during growth, with their morphology widely believed to be dictated by the forces and displacements that they experience. The zygomaticotemporal suture in primates is located in the relatively weak zygomatic arch, and externally it appears a very simple connection. However, large forces are almost certainly transmitted across this suture, suggesting that it requires some level of stability while also allowing controlled movements under high loading. Here we examine the 2- and 3-dimensional (3D) morphology of the zygomaticotemporal suture in an ontogenetic series of Macaca fascicularis skulls. High resolution microcomputed tomography data sets were examined, and virtual and physical 3D replicas were created to assess both structure and general stability. The zygomaticotemporal suture is much more complex than its external appearance suggests, with interlocking facets between the adjacent zygomatic and temporal bones. It appears as if some movement is permitted across the suture in younger animals, but as they approach adulthood the complexity of the suture's interlocking bone facets reaches a level where these movements become minimal

    A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease

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    Multiple myeloma bone disease is devastating for patients and a major cause of morbidity. The disease leads to bone destruction by inhibiting osteoblast activity while stimulating osteoclast activity. Recent advances in multiple myeloma research have improved our understanding of the pathogenesis of multiple myeloma-induced bone disease and suggest several potential therapeutic strategies. However, the effectiveness of some potential therapeutic strategies still requires further investigation and optimization. In this paper, a recently developed mathematical model is extended to mimic and then evaluate three therapies of the disease, namely: bisphosphonates, bortezomib and TGF-β inhibition. The model suggests that bisphosphonates and bortezomib treatments not only inhibit bone destruction, but also reduce the viability of myeloma cells. This contributes to the current debate as to whether bisphosphonate therapy has an anti-tumour effect. On the other hand, the analyses indicate that treatments designed to inhibit TGF-β do not reduce bone destruction, although it appears that they might reduce the viability of myeloma cells, which again contributes to the current controversy regarding the efficacy of TGF-β inhibition in multiple myeloma-induced bone disease

    What Works and What Does Not

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    PonyGE2: Grammatical Evolution in Python

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    Grammatical Evolution (GE) is a population-based evolutionary algorithm, where a formal grammar is used in the genotype to phenotype mapping process. PonyGE2 is an open source implementation of GE in Python, developed at UCD's Natural Computing Research and Applications group. It is intended as an advertisement and a starting-point for those new to GE, a reference for students and researchers, a rapid-prototyping medium for our own experiments, and a Python workout. As well as providing the characteristic genotype to phenotype mapping of GE, a search algorithm engine is also provided. A number of sample problems and tutorials on how to use and adapt PonyGE2 have been developed.Comment: 8 pages, 4 figures, submitted to the 2017 GECCO Workshop on Evolutionary Computation Software Systems (EvoSoft

    Vocational indecision among high school students in Newfoundland

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    A smooth and efficient transfer of young people between school and work seems to be of vital importance to our society. However, an almost anomalous situation seems to exist: Breton and McDonald (1967) report that 33.7 percent of the boys and 19.7 percent of the girls in Grade Eleven in Newfoundland had not made a career choice. -- This study attempted to bring together some of the correlates of vocational indecision and incorporate them into a theoretically meaningful causal scheme. The procedure used in the quantification of the causal model is a generalization of multiple linear regression known as path analysis. The sample consisted of the some 1,600 Grade Eleven students who were part of the Career Decisions Project carried out by Breton and McDonald in 1965-66. -- While this study explained only a small proportion of the variance in vocational indecision, it did result in some elucidation of the complex process of vocational decision-making as it applies to the youth of Newfoundland

    Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model

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    Multiple myeloma (MM)-induced bone disease is mortal for most MM patients. Bisphosphonates are first-line treatment for MM-induced bone disease, since it can inhibit osteoclast activity and the resultant bone resorption by suppressing the differentiation of osteoclast precursors into mature osteoclasts, promoting osteoclast apoptosis and disrupting osteoclast function. However, it is still unclear whether bisphosphonates have an anti-tumour effect. In our previous work, a computational model was built to simulate the pathology of MM-induced bone disease. This paper extends this proposed computational model to investigate the efficacy of bisphosphonates treatment and then clear the controversy of this therapy. The extended model is validated through the good agreement between simulation results and experimental data. The simulation results suggest that bisphosphonates indeed have an anti-tumour effect
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