Energy and thermodynamical study of a small innovative compressed air energy storage system (micro-CAES)

There is a growing interest in the electrical energy storage system, due to the high penetration of the energy produced by renewable sources, the possibility of leveling the absorption peak of the electric network (peak shaving) and the advantage of separating the production phase from the exertion phase (time shift). Compressed air energy storage systems (CAES) are one of the most promising technologies of this field, because they are characterized by a high reliability, low environmental impact and a remarkable energy density. The main disadvantage of big systems is that they depend on geological formations which are necessary to the storage. The micro-CAES system, with a rigid storage vessel, guarantees a high portability of the system and a higher adaptability even with distributed or stand-alone energy productions. This article carries out a thermodynamical and energy analysis of the micro-CAES system, a result of the mathematical model created in a Matlab/Simulink® environment. New ideas will be discussed, as the one concerning the quasi-isothermal compression/expansion, through the exertion of a biphasic mixture, that will increase the total system efficiency and enable a combined production of electric, thermal and refrigeration energies. This is something promising for the development of an experimental devic

Nonmelanoma skin cancers: Embryologically relevant sites and UV exposure

Background: Traditionally, nonmelanoma skin cancers (NMSCs) are considered mainly UV-related malignancies. Nevertheless, a strong correlation between the embryologically relevant sites (ERS) of the head and neck and the preferential sites of onset of basal cell carcinomas (BCCs) has long been supposed and demonstrated. The aim of this research was the investigation of the potential correlation between the ERS of the head and neck and the sites of tumor onset in all of the NMSCs. Methods: The distribution of 1165 NMSC was correlated with the ERS of the head and neck using the universally accepted anatomical diagrams featuring the congenital head and neck clefts and an original anatomical diagram showing the most credited sites of the embryonic fusion planes of the auricle. Results: In our sample, both BCC and SSC display an increased likelihood of onset in the ERS of the head and neck. A proportion of 93.10% BCCs was distributed within ERS, while 6.90% derived from non-embryologically relevant sites (P < 0.001). A proportion of 69.70% SCCs was distributed within ERS, while 30.30% derived from non-embryologically relevant sites (P < 0.001). The probability of tumors within ERS was significantly higher for BCC versus SCC (P < 0.001), with BCCs having a 5-fold increase in the probability of occurring in ERS compared to SCCs (P < 0.001). Conclusions: The ERS might host areas of cellular instability yielding to the development of an NMSC. The environmental UV exposure plays a relatively main role versus dysontogenic factors in the pathogenesis of SCC

Advanced physico-chemical characterization of chitosan by means of TGA coupled on-line with FTIR and GCMS: Thermal degradation and water adsorption capacity

In this study, chitosan, a commercially-available linear polysaccharide mainly used as antibacterial agent, functional coating and drug-delivery system, is investigated to enlighten both water interactions and its thermal stability by using a set of complementary advanced thermal techniques, rarely applied in polysaccharides characterizations. DSC and TGA, here coupled with FTIR and GCMS analysis of the exhausted gas, were used to reveal thermal events and identify degradation products as a function of the temperature: three main steps in chitosan (N-deacetylation degree, DD = 78%) thermal degradation were highlighted and mechanism proposed. In order to make a comparison with other analogous polymeric systems and validate the results obtained, a medical grade chitosan (DD > 93%) and a commercial chitin were investigated too. Moreover, the water adsorption capacity of chitosan (DD = 78%) was followed by using thermo-microgravimetry (TMG) and the distinction between weight losses of both physically and chemically adsorbed water molecules was achieved. The approach followed allows a complete characterization of the thermal behaviors of the chitosan and highlights the need for complementary advanced thermal techniques in the detailed characterization of complex biopolymers

Effects of mycophenolate mofetil on acute ischaemia–reperfusion injury in rats and its consequences in the long term

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Prevalence and severity of anaemia in patients with type 2 diabetic nephropathy and different degrees of chronic renal insufficiency

Background/Aim: Type 2 diabetes mellitus is the single most common cause of chronic kidney disease (CKD); however its real impact on renal anaemia has not been established. The aim of this study was to evaluate whether onset, severity, and prevalence of anaemia during the course of CKD is different between type 2 diabetic and non-diabetic patients. Methods: We enrolled 281 patients with: (1) type 2 diabetes and no CKD (n = 75); (2) type 2 diabetes plus CKD (n = 106), and (3) CKD without type 2 diabetes (n = 100). According to K/DOQI guidelines, the patients with renal insufficiency (i.e., those with a glomerular filtration rate < 60 ml/min) were subgrouped into three tertiles of CKD: (1) stage 3 (creatinine clearance 60-30 ml/min); (2) stage 4 (creatinine clearance 29-15 ml/min), and (3) stage 5 (creatinine clearance < 15 ml/min). Results: Anaemia was observed in 16% of the diabetic patients without CKD; it was more frequent in the diabetic patients with CKD than in the non-diabetic patients with CKD (61.7 vs. 52%, p < 0.05). The comparison among the tertiles showed that the prevalence of anaemia was significantly higher only in diabetic CKD patients of stages 4 and 5. The prevalence was higher in females independently of type 2 diabetes mellitus. In diabetics with a normal renal function, the haemoglobin levels were higher than in diabetics and non-diabetics with CKD, but the diabetics showed lower levels of haemoglobin than non-diabetics at stage 3 and stage 4 of CKD. Conclusions: Diabetic patients with CKD of stages 4 and 5 have a higher prevalence of anaemia than non-diabetic patients with comparable glomerular filtration rate. A higher awareness of this risk will allow earlier diagnosis and treatment. Copyright (c) 2007 S. Karger AG, Basel