Review on the possible tool materials for friction stir welding of steel plates

The friction stir welding (FSW) process is mainly used in industrial applications for joining low melting temperature materials such as aluminium and magnesium. FSW has many advantages in comparison with conventional fusion arc welding. Therefore the interest to use this technique for joining steel plates has grown. However such usage is still limited because of the lack of adequate tool materials. This review gives an overview of possible tool materials for FSW of steels focussing on tungsten, tungsten carbide, pcBN and a few ultra-high temperature ceramics

Electromagnetic Pulse Welded Aluminium to Copper Sheet Joints: Morphological and Mechanical Characterization

This study investigated joining of Al to Cu sheets by electromagnetic pulse welding, which is a solid-state welding process that uses electromagnetic forces to join materials. The interfacial morphology and mechanical properties of the Al/Cu joints were analysed and related to the welding process parameters. The centre section of the Al/Cu joints evolved from a non-welded to a welded zone. The welded zone started with a wavy interface, consisting of thick interfacial layers with defects and evolved to a relatively flat interface without an interfacial layer. Interfacial phases resulted from solid-state mechanical mixing and/or very localised interfacial heating. The interfacial layers had a thickness ranging from 2-39 μm, an interface waviness amplitude up to 11 μm and contained 31-75 wt% Cu. The interfacial layer thickness and the weld length are determined by both the discharge energy and the stand-off distance. A trade-off existed between a homogeneous interface and the maximum weld length when the stand-off distance is changed. The interfacial layer exhibited an increased hardness compared to Al and Cu. A higher tensile force, up to 4,9 kN, was achieved at a higher energy and a lower stand-off distance. One of the factors determining the tensile force was the width of the welded area

Design of Electromagnetic Pulse Crimp Torque Joints

Electromagnetic pulse crimping of form fit joints was investigated using tubes with a diameter of 50 mm and a wall thickness of 1,5 mm, in the aluminium alloy EN AW-6060. The tubes were crimped onto steel internal parts, which were designed to bear torsional loads. Grooved, knurl rolled and knurl cut internal workpieces were used. To assess the torque strength of the connections, a torque test set-up was designed and built. In a first test series, grooved internal parts were used. The influence of the internal workpiece design and the energy level on the torque resistance was investigated. Related to the geometry of the internal workpiece, the following parameters were varied: the groove depth, the groove width, the edge radius and the number of grooves. In a second test series, knurl rolled and knurl cut internal workpieces were used. For the joints with a knurl rolled internal part, the influence of the knurl pattern, defined by the pitch, was investigated. For the connections with a knurl cut internal part, the influence of the energy level was studied. The different joint failure mechanisms were determined

Multi-wire submerged arc welding: a study of secondary process parameters

The goal of this thesis is to investigate the effect of secondary process parameters on the geometry of the weld bead in multi-wire submerged arc welding. Bead-on-plate welding experiments will be conducted using 3, 4 and 5 wires. The parameters being varied will be the wire stick out, the angles of the torches and the spacing in between. Primary process parameters like voltage, current and welding speed will be kept constant. Penetration, bead width and height, percentage dilution, HAZ, weld penetration shape factor and weld reinforcement shape factor will be measured and evaluated. Fewer experiments will be needed because of the use of a design of experiments approach, namely a fractional factorial design. This will allow to determine the significance of each single parameter and their mutual interaction with respect to weld bead shape

Visual acuity outcome of stable proliferative diabetic retinopathy following initial complete panretinal photocoagulation

BACKGROUND: Recent clinical trials on proliferative diabetic retinopathy (PDR) show that presenting visual acuity can be stabilised with panretinal photocoagulation (PRP) within 2 years despite the need for supplementary PRP or anti-vascular endothelial growth factor therapy for concomitant diabetic macular oedema (DMO). It is unclear whether similar results can be obtained in daily clinical practice. Here, we query the probability of vision loss in patients with treatment-naïve PDR who have attained stability after PRP and its predictors. METHODS: Retrospective cohort study at a tertiary eye centre between 01 January 2015 and 31 December 2019, wherein 2336 eyes met study criteria with first record of stable PRP-treated PDR in at least one eye. Kaplan-Meier and Cox proportional hazards modelling were used to report the probability of vision loss of at least five Early Treatment Diabetic Retinopathy Study (ETDRS) letters. RESULTS: The probability of losing at least five ETDRS letters was 50% at 3.32 (95% CI, 2.94 to 3.78) years after achieving first stability post PRP in treatment-naïve PDR. The mean decrease at this event was 14.2 (SD 13.0) ETDRS letters irrespective of the presence of DMO. The strongest risk factor for vision loss was a history of DMO at baseline (HR 1.62 (95% CI, 1.34 to 1.95), p<0.001). DISCUSSION: One in two patients with stable treated PDR lose a line of vision by 3.5 years. This resulted in 15% of patients losing their eligibility to drive. Notably, 13% of the cohort died during the follow-up period

Stellar parameters of Be stars observed with X-shooter

Aims. The X-shooter archive of several thousand telluric star spectra was skimmed for Be and Be-shell stars to derive the stellar fundamental parameters and statistical properties, in particular for the less investigated late type Be stars, and the extension of the Be phenomenon into early A stars. Methods. An adapted version of the BCD method is used, utilizing the Balmer discontinuity parameters to determine effective temperature and surface gravity. This method is optimally suited for late B stars. The projected rotational velocity was obtained by profile fitting to the Mg ii lines of the targets, and the spectra were inspected visually for the presence of peculiar features such as the infrared Ca ii triplet or the presence of a double Balmer discontinuity. The Balmer line equivalent widths were measured, but due to uncertainties in determining the photospheric contribution are useful only in a subsample of Be stars for determining the pure emission contribution. Results. A total of 78 Be stars, mostly late type ones, were identified in the X-shooter telluric standard star archive, out of which 48 had not been reported before. The general trend of late type Be stars having more tenuous disks and being less variable than early type ones is confirmed. The relatively large number (48) of relatively bright (V > 8.5) additional Be stars casts some doubt on the statistics of late type Be stars; they are more common than currently thought: The Be/B star fraction may not strongly depend on spectral subtype.Comment: Accepted for publication in A&

Comparison of commonly used methods in random effects meta-analysis:Application to preclinical data in drug discovery research

Background Meta-analysis of preclinical data is used to evaluate the consistency of findings and to inform the design and conduct of future studies. Unlike clinical meta-analysis, preclinical data often involve many heterogeneous studies reporting outcomes from a small number of animals. Here, we review the methodological challenges in preclinical meta-analysis in estimating and explaining heterogeneity in treatment effects.Methods Assuming aggregate-level data, we focus on two topics: (1) estimation of heterogeneity using commonly used methods in preclinical meta-analysis: method of moments (DerSimonian and Laird; DL), maximum likelihood (restricted maximum likelihood; REML) and Bayesian approach; (2) comparison of univariate versus multivariable meta-regression for adjusting estimated treatment effects for heterogeneity. Using data from a systematic review on the efficacy of interleukin-1 receptor antagonist in animals with stroke, we compare these methods, and explore the impact of multiple covariates on the treatment effects.Results We observed that the three methods for estimating heterogeneity yielded similar estimates for the overall effect, but different estimates for between-study variability. The proportion of heterogeneity explained by a covariate is estimated larger using REML and the Bayesian method as compared with DL. Multivariable meta-regression explains more heterogeneity than univariate meta-regression.Conclusions Our findings highlight the importance of careful selection of the estimation method and the use of multivariable meta-regression to explain heterogeneity. There was no difference between REML and the Bayesian method and both methods are recommended over DL. Multiple meta-regression is worthwhile to explain heterogeneity by more than one variable, reducing more variability than any univariate models and increasing the explained proportion of heterogeneity

Predicting Incremental and Future Visual Change in Neovascular Age-Related Macular Degeneration Using Deep Learning

PURPOSE: To evaluate the predictive utility of quantitative imaging biomarkers, acquired automatically from optical coherence tomography (OCT) scans, of cross-sectional and future visual outcomes of patients with neovascular age-related macular degeneration (AMD) starting anti-vascular endothelial growth factor (VEGF) therapy. DESIGN: Retrospective cohort study. PARTICIPANTS: Treatment-naïve, first-treated eyes of patients with neovascular AMD between 2007 and 2017 at Moorfields Eye Hospital (a large, UK single-centre) undergoing anti-VEGF therapy METHODS: Automatic segmentation was carried out by applying a deep learning segmentation algorithm to 137,379 OCT scans from 6467 eyes of 3261 patients with neovascular AMD. After applying selection criteria 926 eyes of 926 patients were taken forward for analysis. MAIN OUTCOME MEASURES: Correlation coefficients (R2) and mean absolute error (MAE) between quantitative OCT (qOCT) parameters and cross-sectional visual-function. The predictive value of these parameters for short-term visual change i.e. incremental visual acuity [VA] resulting from an individual injection, as well as, VA at distant timepoints (up to 12 months post-baseline). RESULTS: VA at distant timepoints could be predicted: R2 0.80 (MAE 5.0 ETDRS letters) and R2 0.7 (MAE 7.2) post-injection 3 and at 12 months post-baseline (both p < 0.001), respectively. Best performing models included both baseline qOCT parameters and treatment-response. Furthermore, we present proof-of-principle evidence that the incremental change in VA from an injection can be predicted: R2 0.14 (MAE 5.6) for injection 2 and R2 0.11 (MAE 5.0) for injection 3 (both p < 0.001). CONCLUSIONS: Automatic segmentation enables rapid acquisition of quantitative and reproducible OCT biomarkers with potential to inform treatment decisions in the care of neovascular AMD. This furthers development of point-of-care decision-aid systems for personalized medicine

Re-evaluating diabetic papillopathy using optical coherence tomography and inner retinal sublayer analysis.

BACKGROUND/OBJECTIVES: To re-evaluate diabetic papillopathy using optical coherence tomography (OCT) for quantitative analysis of the peripapillary retinal nerve fibre layer (pRNFL), macular ganglion cell layer (mGCL) and inner nuclear layer (mINL) thickness. SUBJECTS/METHODS: In this retrospective observational case series between June 2008 and July 2019 at Moorfields Eye hospital, 24 eyes of 22 patients with diabetes and optic disc swelling with confirmed diagnosis of NAION or diabetic papillopathy by neuro-ophthalmological assessment were included for evaluation of the pRNFL, mGCL and mINL thicknesses after resolution of optic disc swelling. RESULTS: The mean age of included patients was 56.5 (standard deviation (SD) ± 14.85) years with a mean follow-up duration of 216 days. Thinning of pRNFL (mean: 66.26, SD ± 31.80 µm) and mGCL (mean volume: 0.27 mm3, SD ± 0.09) were observed in either group during follow-up, the mINL volume showed no thinning with 0.39 ± 0.05 mm3. The mean decrease in visual acuity was 4.13 (SD ± 14.27) ETDRS letters with a strong correlation between mGCL thickness and visual acuity (rho 0.74, p < 0.001). CONCLUSION: After resolution of acute optic disc swelling, atrophy of pRNFL and mGCL became apparent in all cases of diabetic papillopathy and diabetic NAION, with preservation of mINL volumes. Analysis of OCT did not provide a clear diagnostic distinction between both entities. We suggest a diagnostic overlay with the degree of pRNFL and mGCL atrophy of prognostic relevance for poor visual acuity independent of the semantics of terminology