A case of acromegaly presenting with hemiplegia is described. The radiological features, including cerebral angiography, are discussed. Acromegaly is uncommon in the Black population of South Africa. Experience at Baragwanath Hospital (2400 beds) confirms the rarity of the disease, and reference to the South African Medical Journal over the past 25 years has failed to reveal a single case. In all published series no case of 'stroke' in acromegaly is specifically described. This is unusual because of the many underlying aetiological factors of potential stroke present in acromegaly.S. Afr. Med. J., 48, 684 (1974)