Chitosan/glycosaminoglycan scaffolds for skin reparation

Burns and chronic wounds, often related to chronic diseases (as diabetes and cancer), are challenging lesions, difficult to heal. The prompt and full reconstitution of a functional skin is at the basis of the development of biopolymer-based scaffolds, representing a 3D substrate mimicking the dermal extracellular matrix. Aim of the work was to develop scaffolds intended for skin regeneration, according to: fabrication by electrospinning from aqueous polysaccharide solutions; prompt and easy treatment to obtain scaffolds insoluble in aqueous fluids; best performance in supporting wound healing. Three formulations were tested, based on chitosan (CH)and pullulan (P), associated with glycosaminoglycans (chondroitin sulfate - CS or hyaluronic acid \u2013 HA). A multidisciplinary approach has been used: chemico-physical characterization and preclinical evaluation allowed to obtain integrated information. This supports that CS gives distinctive properties and optimal features to the scaffold structure for promoting cell proliferation leading tissue reparation towards a complete skin restore

Effect of tecovirimat on healing time and viral clearance by emulation of a target trial in patients hospitalized for mpox

Tecovirimat is a treatment option for severe mpox, although randomized clinical trials are ongoing. The aim of the study is to assess the effect of tecovirimat on healing time and the extent of viral clearance by target trial emulation using observational data. Clinical and virological data of patients hospitalized for mpox were collected. Samples from the upper respiratory tract (URT) were grouped in two time points: T1 (median 6 days from symptoms onset) and T2 (median 5 days from T1). Patients were followed-up until recovery. Average treatment effect (ATE) in patients untreated versus treated with tecovirimat was estimated on time to healing and variation in viral load in URT, using a weighted and cloning analysis. Among the 41 patients included, 19 completed a course of tecovirimat. The median time from symptoms onset to hospitalization and to drug-starting was 4 days and 10 days, respectively. No improvement in healing time in treated versus untreated was observed. No difference by treatment group in time to viral clearance was detected by ATE fitted in a subset of 13 patients after controlling for confounders. We found no evidence for a large effect of tecovirimat in shortening healing time and viral clearance. While awaiting the results of randomized studies, the use of tecovirimat should be restricted to the clinical trial setting

La nueva humanización del agua : una lectura desde el ambientalismo inclusivo

¿Y si sostuviéramos que -lejos de las extendidas estigmatizaciones que asocian la juventud de sectores populares con la delincuencia- un gran número de jóvenes de comunidades golpeadas por la violencia social y la ausencia de políticas públicas dedicara sus días a cuidar de otros jóvenes? El trabajo de Yicel Giraldo Giraldo y Alexander Ruiz Silva estudia la solidaridad como eje y motor de las organizaciones sociales juveniles volcadas a cuidar de sus semejantes, ensayando una interpretación de las apuestas éticas y políticas que despliegan las y los jóvenes de las comunas de Medellín para enfrentar situaciones adversas marcadas por el dolor y el sufrimiento. A través de 32 historias de vida de jóvenes, Solidaridad propone reconstruir la compleja trama de iniciativas y acciones solidarias que impulsan los jóvenes de las comunas de Medellín. La música, el audiovisual, la danza, el arte del grafiti y la defensa del medioambiente, son plataformas desde donde los jóvenes convocan al otro, lo afectan, lo conmueven, lo convocan a hacer comunidad